NSTL国家科技图书文献中心

1. Genetically humanized phenylketonuria mouse model as a testing tool for human genome editing in fertilized eggs NSTL国家科技图书文献中心

Tsuji-Hosokawa, Atsu... | Tsuchiya, Iku ... - 《Journal of inherited metabolic disease》 - 2025,48(1) - e12803～e12803 - 共14页

摘要： gametes from a genetically humanized* mouse model using a* | utility of sgRNA. The genetically humanized* mouse model* | a genetically humanized* mouse model will provide* | phenylketonuria (PKU) mouse* model to gain insights into genome* | editing in human embryos. The human PKU mouse* model Pah*

关键词： genetically humanized mouse model | genome editing | phenylketonuria

2. Targeting the Progression of Lupus-Like Disease in Humanized Mouse Model by Specific Dietary Components NSTL国家科技图书文献中心

Ralchev, Nikola | Kechidzhieva, Lidiya ... - 《Molecular Nutrition and Food Research》 - 2025,69(3) - 共8页

摘要： adaptive immune responses. Spontaneous and induced mouse | of humanized* models, engrafted with lupus patients* | humanized mice fed with the control diet. The observed | Systemic lupus erythematosus (SLE) is a | complex autoimmune disease with a number of

关键词： diet | DNA methylation | epigenetics | humanized models | immune modulation

3. Generation of a Severe Hemophilia A Humanized Mouse Model Capable of Inducing an Anti-FVIII Immune Response NSTL国家科技图书文献中心

Oda, Akihisa | Furukawa, Shoko ... - 《Thrombosis and Haemostasis》 - 2025,125(5) - 435～446 - 共12页

摘要：) transplantation and established a HA mouse with a humanized | and LPS. Taken together, our humanized* mice with HA* | Background Factor VIII (FVIII) replacement | therapy induces anti-FVIII neutralizing antibodies in | approximately 30% of patients with severe hemophilia A (HA

关键词： humanized mice | severe hemophilia A | anti-FVIII immune response | NOG mice

4. Challenges and opportunities for conceiving genetically diverse sickle cell mice NSTL国家科技图书文献中心

Rafiou Agoro | Gary A. Churchill - 《Trends in molecular medicine》 - 2025,31(5) - 413～423 - 共11页

摘要： interventions. To achieve this, humanized* and genetically* | diverse mouse* models are essential for associating* | A milestone in sickle cell disease (SCD | ) therapeutics was achieved in December 2023 with the FDA | -approved gene therapy for patients aged 12 years and

关键词： genetically diverse mice; humanized mouse models; sickle cell disease

5. Lactobacillus casei Cell Wall Extract and Production of Galactose-Deficient IgA1 in a Humanized IGHA1 Mouse Model NSTL国家科技图书文献中心

Li, Run | Wang, Manliu ... - 《Journal of the American Society of Nephrology》 - 2025,36(1) - 60～72 - 共13页

摘要： humanized IgA1 mouse model with transgenic expression of | , mouse* models that can be used to study Gd-IgA1's* | the human IGHA1 gene from the mouse* chromosomal* | develop a mouse* model of IgA nephropathy. Results* | Background IgA nephropathy is the most common

关键词： CKD | glomerular disease | IgA | IgA deposition | IgA nephropathy | immune complexes

6. Characteristics of immune response and pathogen tissue dissemination during progressive Treponema pallidum infection: Insights from humanized mice NSTL国家科技图书文献中心

Zheng, Ya-Wen | Zheng, Xin-Qi ... - 《Scandinavian journal of immunology.》 - 2025,101(3) - e70005～e70005 - 共12页

摘要： on syphilis using the Hu-HSC mouse* model and offer* | Characterizing the immune response and | pathogen tissue dissemination during progressive | Treponema pallidum (T. pallidum) infection in the human is | crucial for comprehending syphilis but it remains poorly

关键词： humanized mouse | immune response | pathogenic dissemination | Treponema pallidum

7. Advances in bacterial artificial chromosome (BAC) transgenic mice for gene analysis and disease research NSTL国家科技图书文献中心

Mogi, Kazumasa | Tomita, Hiroyuki ... - 《Gene》 - 2025,934 - 149014～149014 - 共12页

摘要： thorough examination of BAC transgenic mouse* technology* | , encompassing both traditional and humanized* models. We* | limitations, humanized* BAC transgenic mice have proven to be* | Transgenic mice, including those created using | Bacterial Artificial Chromosomes (BACs), are artificial

关键词： Genetically modified mice | Bacterial Artificial Chromosome (BAC) | Transgenic mouse technology | Humanized BAC transgenic mice | Pathogenesis | animal model

8. Humanized rodent models of neurodegenerative diseases and other brain disorders NSTL国家科技图书文献中心

Zhang, Xinru | Wang, Jianxiang ... - 《Neuroscience and Biobehavioral Reviews》 - 2025,172 - Article 106112～Article 106112 - 共18页

摘要：, researchers have developed humanized* animal models. These* | , significance, and limitations of humanized* rodent models in* | , and others. Humanized* rodent models have expanded* | Central Nervous System (CNS) diseases | significantly affect human health. However, replicating the

关键词： Humanized model | Central nervous system diseases | Transgenic | Humanized chimeric mouse | Gene knock-in model | Pathogenesis

9. A Chimeric Virus-Like Particle Vaccine Presenting an Immunodominant Epitope of gB Elicited Potent Neutralizing Antibodies against EBV Infection In Vitro and In Vivo NSTL国家科技图书文献中心

Zhong, Ling | Zhang, Wanlin ... - 《ACS applied materials & interfaces》 - 2025,17(18) - 26252～26262 - 共11页

摘要： EBV infection in a humanized* mouse model, indicating* | infection in a humanized* mouse model. We demonstrated that* | Epstein-Barr Virus (EBV) as the first | characterized tumorigenic virus in humans causes heavy disease | burdens. An effective vaccine is urgently needed to

关键词： Epstein-Barr virus | gB | HBc-149 | Chimericvirus-like particle vaccine | Neutralizing antibodies

10. Immune-deficient MISTRG mice support expansion of leukaemia-initiating cells in xenograft models of paediatric acute myeloid leukaemia NSTL国家科技图书文献中心

Connerty, Patrick | Xie, Jinhan ... - 《British Journal of Haematology》 - 2025,206(4) - 1092～1096 - 共5页

摘要： models is challenging. Two humanized* mouse strains* | Acute myeloid leukaemia (AML) remains a deadly | disease, largely due to the persistence of drug | -resistant leukaemia-initiating cells (LICs) which promote | relapse. Therefore, effective therapies must target LICs

关键词： acute myeloid Leukaemia | leukaemia-initiating cells | MISTRG | NRGS | patient-derived xenograft | leukaemia‐initiating cells | patient‐derived xenograft

摘要： gametes from a genetically humanized mouse model using a | utility of sgRNA. The genetically humanized mouse model | a genetically humanized mouse model will provide | phenylketonuria (PKU) mouse model to gain insights into genome | editing in human embryos. The human PKU mouse model Pah

关键词： genetically humanized mouse model | genome editing | phenylketonuria

摘要： adaptive immune responses. Spontaneous and induced mouse | of humanized models, engrafted with lupus patients | humanized mice fed with the control diet. The observed | Systemic lupus erythematosus (SLE) is a | complex autoimmune disease with a number of

关键词： diet | DNA methylation | epigenetics | humanized models | immune modulation

摘要：) transplantation and established a HA mouse with a humanized | and LPS. Taken together, our humanized mice with HA | Background Factor VIII (FVIII) replacement | therapy induces anti-FVIII neutralizing antibodies in | approximately 30% of patients with severe hemophilia A (HA

关键词： humanized mice | severe hemophilia A | anti-FVIII immune response | NOG mice

摘要： interventions. To achieve this, humanized and genetically | diverse mouse models are essential for associating | A milestone in sickle cell disease (SCD | ) therapeutics was achieved in December 2023 with the FDA | -approved gene therapy for patients aged 12 years and

关键词： genetically diverse mice; humanized mouse models; sickle cell disease

摘要： humanized IgA1 mouse model with transgenic expression of | , mouse models that can be used to study Gd-IgA1's | the human IGHA1 gene from the mouse chromosomal | develop a mouse model of IgA nephropathy. Results | Background IgA nephropathy is the most common

关键词： CKD | glomerular disease | IgA | IgA deposition | IgA nephropathy | immune complexes

摘要： on syphilis using the Hu-HSC mouse model and offer | Characterizing the immune response and | pathogen tissue dissemination during progressive | Treponema pallidum (T. pallidum) infection in the human is | crucial for comprehending syphilis but it remains poorly

关键词： humanized mouse | immune response | pathogenic dissemination | Treponema pallidum

摘要： thorough examination of BAC transgenic mouse technology | , encompassing both traditional and humanized models. We | limitations, humanized BAC transgenic mice have proven to be | Transgenic mice, including those created using | Bacterial Artificial Chromosomes (BACs), are artificial