NSTL国家科技图书文献中心

1. TAT-1, a phosphatidylserine flippase, affects molting and regulates membrane trafficking in the epidermis of Caenorhabditis elegans NSTL国家科技图书文献中心

Milne, Shae M. | Edeen, Philip T.... - 《Genetics》 - 2025,229(3) - 共16页

摘要： mammalian ATP8A1/2, a phosphatidylserine flippase* that* | phosphatidylserine biosynthesis. We propose that TAT-1 flippase | Membrane trafficking is a conserved process | required for the import, export, movement, and | distribution of proteins and other macromolecules within

关键词： phosphatidylserine | flippase | molting | endocytosis | membrane lipids | membrane trafficking | TAT-1 | CHAT-1 | NEKL-2 | NEKL-3...

2. Nisin resistance is increased through GtcA mutation induced loss of cell wall teichoic acid N-acetylglucosamine modifications in Listeria monocytogenes NSTL国家科技图书文献中心

Mandinyenya, Toruvan... | Wambui, Joseph ... - 《International Journal of Food Microbiology》 - 2025,428 - 共13页

摘要：. The GtcA flippase* enzyme is functionally crucial in* | Nisin resistance development is one of food | safety challenges posed by Listeria monocytogenes, an | important foodborne pathogen that causes human listeriosis | two separate pathways that glycosylate cell envelope

关键词： GtcA | Nisin resistance | Listeria monocytogenes | Cell envelope | Wall teichoic acids | N-Acetylglucosamine | Hydrophobicity

3. De Novo Missense Variations of ATP8B2 Impair Its Phosphatidylcholine Flippase Activity NSTL国家科技图书文献中心

Takatsu, Hiroyuki | Nishimura, Narumi ... - 《Molecular and Cellular Biology》 - 2024,44(11) - 473～488 - 共16页

摘要： phosphatidylcholine flippase* at the plasma membrane, but its* | phosphatidylcholine flippase* activity of ATP8B2. Furthermore* | ATP11C were found to decrease their flippase* activities* | P4-ATPases comprise a family of lipid | flippases that translocate lipids from the exoplasmic (or

关键词： Lipid bilayer | P-type ATPase | flippase

4. Direct evidence of lipid transport by the Drs2–Cdc50 flippase upon truncation of its terminal regions NSTL国家科技图书文献中心

Sara Abad Herrera | Bo H?jen Justesen ... - 《Protein science :》 - 2024,33(3) - e4855～e4855 - 共6页

摘要： yeast lipid flippase* Drs2–Cdc50. By functionally* | compelling evidence that lipid flippase* activity is* | transport by the Drs2–Cdc50 flippase. | Abstract P4‐ATPases in complex with Cdc50 | subunits are lipid flippases that couple ATP hydrolysis

关键词： lipid flippase | membrane transporter | P4‐ATPase | phosphoinositides | reconstitution

5. The lipid flippase ATP8A1 regulates the recruitment of ARF effectors to the trans-Golgi Network NSTL国家科技图书文献中心

Pocognoni, Cristian ... | Nawara, Tomasz ... - 《Archives of Biochemistry and Biophysics》 - 2024,758 - 共13页

摘要： flippase tail to the Sec7 domain of BIG1/BIG2 increases | in which a flippase* component of the deformation* | Formation of transport vesicles requires the | coordinate activity of the coating machinery that selects | cargo into the nascent vesicle and the membrane

关键词： Sec7 | BIG1 | BIG2 | Lipid flippase | trans-Golgi-network (TGN) | Arf effector | GGA | Golgin

6. Heterogenous Expression and Purification of Lipid II Flippase from Staphylococcus aureus NSTL国家科技图书文献中心

Zheng, Yuan Yuan | Chung, Wai-Hong ... - 《Protein and peptide letters》 - 2024,31(5) - 386～394 - 共9页

摘要： membrane protein functioning as Lipid II flippase, is a | Background Staphylococcus aureus is a common | pathogen with strains that are resistant to existing | antibiotics. MurJ from S. aureus (SaMurJ), an integral | potential target for developing new antibacterial agents

关键词： Staphylococcus aureus | lipid II Flippase | MurJ | protein purification | detergent screening | buffer | MEMBRANE-PROTEINS | MVIN HOMOLOG | MURJ MVIN | IDENTIFICATION...

7. The lipid flippase ATP10B enables cellular lipid uptake under stress conditions NSTL国家科技图书文献中心

Wouters, Rosanne | Beletchi, Igor ... - 《Biochimica et biophysica acta. Molecular cell research》 - 2024,1871(2) - 119652～119652 - 共6页

摘要： ATP10B as a late endo-/lysosomal lipid flippase | data show that the endo-/lysosomal lipid flippase | Pathogenic ATP10B variants have been described | in patients with Parkinson's disease and dementia | with Lewy body disease, and we previously established

关键词： Endo-/lysosomes | Lipid transport | Phosphatidylcholine | Glucosylceramide | Parkinson 's disease | ATPASE | PHOSPHATIDYLCHOLINE

8. On the track of the lipid transport pathway of the phospholipid flippase ATP8A2 - Mutation analysis of residues of the transmembrane segments M1, M2, M3 and M4 NSTL国家科技图书文献中心

Mogensen L.S. | Mikkelsen S.A.... - 《Biochimica et biophysica acta. Molecular cell research》 - 2024,1871(1) - 119570～119570 - 共6页 - 被引量：2

摘要： segments M1, M2, M3, and M4 of the flippase* ATP8A2, thus* | ? 2023 The AuthorsP4-ATPases, also known as | flippases, translocate specific lipids from the exoplasmic | leaflet to the cytoplasmic leaflet of biological | membranes, thereby generating an asymmetric lipid

关键词： Enzyme mechanism | Mutagenesis | P-type ATPase | P4-ATPase | Phospholipid transport | Zipper

9. The Phospholipid Flippase ATP8B1 is Involved in the Pathogenesis of Ulcerative Colitis via Establishment of Intestinal Barrier Function NSTL国家科技图书文献中心

Koelink, Pim J. | Gomez-Mellado, Valen...... - 《Journal of Crohn’s & colitis》 - 2024,18(7) - 1134～1146 - 共13页 - 被引量：1

摘要：Aims Patients with mutations in ATP8B1 develop | progressive familial intrahepatic cholestasis type 1 [PFIC1 | ], a severe liver disease that requires life-saving | liver transplantation. PFIC1 patients also present | with gastrointestinal problems, including intestinal

关键词： IBD | Ulcerative Colitis | Intestinal Epithelial Barrier | CLDN4 | FAMILIAL INTRAHEPATIC CHOLESTASIS | LIVER-TRANSPLANTATION | 2 FORMS | EXPRESSION | MEMBRANE | PROTEIN...

10. Elucidating Daptomycin's Antibacterial Efficacy: Insights into the Tripartite Complex with Lipid II and Phospholipids in Bacterial Septum Membrane NSTL国家科技图书文献中心

Srivastava, Diship | Patra, Niladri - 《The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical》 - 2024,128(18) - 4414～4427 - 共14页 - 被引量：1

摘要：This study elucidated the mechanism of | formation of a tripartite complex containing daptomycin | (Dap), lipid II, and phospholipid | phosphatidylglycerol in the bacterial septum membrane, which was | previously reported as the cause of the antibacterial

摘要： mammalian ATP8A1/2, a phosphatidylserine flippase* that* | phosphatidylserine biosynthesis. We propose that TAT-1 flippase | Membrane trafficking is a conserved process | required for the import, export, movement, and | distribution of proteins and other macromolecules within

关键词： phosphatidylserine | flippase | molting | endocytosis | membrane lipids | membrane trafficking | TAT-1 | CHAT-1 | NEKL-2 | NEKL-3...

摘要：. The GtcA flippase* enzyme is functionally crucial in* | Nisin resistance development is one of food | safety challenges posed by Listeria monocytogenes, an | important foodborne pathogen that causes human listeriosis | two separate pathways that glycosylate cell envelope

关键词： GtcA | Nisin resistance | Listeria monocytogenes | Cell envelope | Wall teichoic acids | N-Acetylglucosamine | Hydrophobicity

摘要： phosphatidylcholine flippase* at the plasma membrane, but its* | phosphatidylcholine flippase* activity of ATP8B2. Furthermore* | ATP11C were found to decrease their flippase* activities* | P4-ATPases comprise a family of lipid | flippases that translocate lipids from the exoplasmic (or

关键词： Lipid bilayer | P-type ATPase | flippase

摘要： yeast lipid flippase* Drs2–Cdc50. By functionally* | compelling evidence that lipid flippase* activity is* | transport by the Drs2–Cdc50 flippase. | Abstract P4‐ATPases in complex with Cdc50 | subunits are lipid flippases that couple ATP hydrolysis

关键词： lipid flippase | membrane transporter | P4‐ATPase | phosphoinositides | reconstitution

摘要： flippase tail to the Sec7 domain of BIG1/BIG2 increases | in which a flippase* component of the deformation* | Formation of transport vesicles requires the | coordinate activity of the coating machinery that selects | cargo into the nascent vesicle and the membrane

关键词： Sec7 | BIG1 | BIG2 | Lipid flippase | trans-Golgi-network (TGN) | Arf effector | GGA | Golgin

摘要： membrane protein functioning as Lipid II flippase, is a | Background Staphylococcus aureus is a common | pathogen with strains that are resistant to existing | antibiotics. MurJ from S. aureus (SaMurJ), an integral | potential target for developing new antibacterial agents

关键词： Staphylococcus aureus | lipid II Flippase | MurJ | protein purification | detergent screening | buffer | MEMBRANE-PROTEINS | MVIN HOMOLOG | MURJ MVIN | IDENTIFICATION...

摘要： ATP10B as a late endo-/lysosomal lipid flippase | data show that the endo-/lysosomal lipid flippase | Pathogenic ATP10B variants have been described | in patients with Parkinson's disease and dementia | with Lewy body disease, and we previously established

关键词： Endo-/lysosomes | Lipid transport | Phosphatidylcholine | Glucosylceramide | Parkinson 's disease | ATPASE | PHOSPHATIDYLCHOLINE

摘要： segments M1, M2, M3, and M4 of the flippase* ATP8A2, thus* | ? 2023 The AuthorsP4-ATPases, also known as | flippases, translocate specific lipids from the exoplasmic | leaflet to the cytoplasmic leaflet of biological | membranes, thereby generating an asymmetric lipid

关键词： Enzyme mechanism | Mutagenesis | P-type ATPase | P4-ATPase | Phospholipid transport | Zipper

摘要：Aims Patients with mutations in ATP8B1 develop | progressive familial intrahepatic cholestasis type 1 [PFIC1 | ], a severe liver disease that requires life-saving | liver transplantation. PFIC1 patients also present | with gastrointestinal problems, including intestinal

关键词： IBD | Ulcerative Colitis | Intestinal Epithelial Barrier | CLDN4 | FAMILIAL INTRAHEPATIC CHOLESTASIS | LIVER-TRANSPLANTATION | 2 FORMS | EXPRESSION | MEMBRANE | PROTEIN...

摘要：This study elucidated the mechanism of | formation of a tripartite complex containing daptomycin | (Dap), lipid II, and phospholipid | phosphatidylglycerol in the bacterial septum membrane, which was | previously reported as the cause of the antibacterial

关键词： GENERAL FORCE-FIELD | MOLECULAR-DYNAMICS | SOFTWARE NEWS | GUI | FLIPPASE | LIPOPEPTIDE | VALIDATION | MECHANISMS | EXTENSION | BILAYERS

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： mammalian ATP8A1/2, a phosphatidylserine flippase that | phosphatidylserine biosynthesis. We propose that TAT-1 flippase | Membrane trafficking is a conserved process | required for the import, export, movement, and | distribution of proteins and other macromolecules within

关键词： phosphatidylserine | flippase | molting | endocytosis | membrane lipids | membrane trafficking | TAT-1 | CHAT-1 | NEKL-2 | NEKL-3...

摘要：. The GtcA flippase enzyme is functionally crucial in | Nisin resistance development is one of food | safety challenges posed by Listeria monocytogenes, an | important foodborne pathogen that causes human listeriosis | two separate pathways that glycosylate cell envelope

关键词： GtcA | Nisin resistance | Listeria monocytogenes | Cell envelope | Wall teichoic acids | N-Acetylglucosamine | Hydrophobicity

摘要： phosphatidylcholine flippase at the plasma membrane, but its | phosphatidylcholine flippase activity of ATP8B2. Furthermore | ATP11C were found to decrease their flippase activities | P4-ATPases comprise a family of lipid | flippases that translocate lipids from the exoplasmic (or

关键词： Lipid bilayer | P-type ATPase | flippase

摘要： yeast lipid flippase Drs2–Cdc50. By functionally | compelling evidence that lipid flippase activity is | transport by the Drs2–Cdc50 flippase. | Abstract P4‐ATPases in complex with Cdc50 | subunits are lipid flippases that couple ATP hydrolysis

关键词： lipid flippase | membrane transporter | P4‐ATPase | phosphoinositides | reconstitution

摘要： flippase tail to the Sec7 domain of BIG1/BIG2 increases | in which a flippase component of the deformation | Formation of transport vesicles requires the | coordinate activity of the coating machinery that selects | cargo into the nascent vesicle and the membrane

关键词： Sec7 | BIG1 | BIG2 | Lipid flippase | trans-Golgi-network (TGN) | Arf effector | GGA | Golgin

摘要： membrane protein functioning as Lipid II flippase, is a | Background Staphylococcus aureus is a common | pathogen with strains that are resistant to existing | antibiotics. MurJ from S. aureus (SaMurJ), an integral | potential target for developing new antibacterial agents

关键词： Staphylococcus aureus | lipid II Flippase | MurJ | protein purification | detergent screening | buffer | MEMBRANE-PROTEINS | MVIN HOMOLOG | MURJ MVIN | IDENTIFICATION...

摘要： ATP10B as a late endo-/lysosomal lipid flippase | data show that the endo-/lysosomal lipid flippase | Pathogenic ATP10B variants have been described | in patients with Parkinson's disease and dementia | with Lewy body disease, and we previously established

关键词： Endo-/lysosomes | Lipid transport | Phosphatidylcholine | Glucosylceramide | Parkinson 's disease | ATPASE | PHOSPHATIDYLCHOLINE

摘要： segments M1, M2, M3, and M4 of the flippase ATP8A2, thus | ? 2023 The AuthorsP4-ATPases, also known as | flippases, translocate specific lipids from the exoplasmic | leaflet to the cytoplasmic leaflet of biological | membranes, thereby generating an asymmetric lipid

关键词： Enzyme mechanism | Mutagenesis | P-type ATPase | P4-ATPase | Phospholipid transport | Zipper

摘要：Aims Patients with mutations in ATP8B1 develop | progressive familial intrahepatic cholestasis type 1 [PFIC1 | ], a severe liver disease that requires life-saving | liver transplantation. PFIC1 patients also present | with gastrointestinal problems, including intestinal

关键词： IBD | Ulcerative Colitis | Intestinal Epithelial Barrier | CLDN4 | FAMILIAL INTRAHEPATIC CHOLESTASIS | LIVER-TRANSPLANTATION | 2 FORMS | EXPRESSION | MEMBRANE | PROTEIN...

摘要：This study elucidated the mechanism of | formation of a tripartite complex containing daptomycin | (Dap), lipid II, and phospholipid | phosphatidylglycerol in the bacterial septum membrane, which was | previously reported as the cause of the antibacterial

关键词： GENERAL FORCE-FIELD | MOLECULAR-DYNAMICS | SOFTWARE NEWS | GUI | FLIPPASE | LIPOPEPTIDE | VALIDATION | MECHANISMS | EXTENSION | BILAYERS

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： mammalian ATP8A1/2, a phosphatidylserine flippase* that* | phosphatidylserine biosynthesis. We propose that TAT-1 flippase | Membrane trafficking is a conserved process | required for the import, export, movement, and | distribution of proteins and other macromolecules within

摘要：. The GtcA flippase* enzyme is functionally crucial in* | Nisin resistance development is one of food | safety challenges posed by Listeria monocytogenes, an | important foodborne pathogen that causes human listeriosis | two separate pathways that glycosylate cell envelope

摘要： phosphatidylcholine flippase* at the plasma membrane, but its* | phosphatidylcholine flippase* activity of ATP8B2. Furthermore* | ATP11C were found to decrease their flippase* activities* | P4-ATPases comprise a family of lipid | flippases that translocate lipids from the exoplasmic (or

摘要： yeast lipid flippase* Drs2–Cdc50. By functionally* | compelling evidence that lipid flippase* activity is* | transport by the Drs2–Cdc50 flippase. | Abstract P4‐ATPases in complex with Cdc50 | subunits are lipid flippases that couple ATP hydrolysis

摘要： flippase tail to the Sec7 domain of BIG1/BIG2 increases | in which a flippase* component of the deformation* | Formation of transport vesicles requires the | coordinate activity of the coating machinery that selects | cargo into the nascent vesicle and the membrane

摘要： segments M1, M2, M3, and M4 of the flippase* ATP8A2, thus* | ? 2023 The AuthorsP4-ATPases, also known as | flippases, translocate specific lipids from the exoplasmic | leaflet to the cytoplasmic leaflet of biological | membranes, thereby generating an asymmetric lipid