NSTL国家科技图书文献中心

1. Autophagy‐Mediated Targeted Protein Degradation NSTL国家科技图书文献中心

Jinning Shao | Shangzhi Xie ... - 《ChemMedChem》 - 2025,20(6) - n/a～n/a - 共6页

摘要：, strategies for targeted* protein degradation (TPD) have been* | degradation and facilitating the recycling of the breakdown | powerful autophagy‐lysosomal degradation* system* | Abstract Autophagy is an evolutionarily | conserved turnover process in eukaryotes, mediating the

关键词： Autophagy | Targeted protein degradation | Small molecule | Macromolecule chimera

2. Utilizing aptamers in targeted protein degradation strategies for disease therapy NSTL国家科技图书文献中心

Li, Lin | Xie, Songbo ... - 《Journal of Pathology》 - 2025,266(2) - 134～143 - 共10页

摘要：Targeted protein degradation (TPD) has emerged | specificity and affinity for protein* targets - have* | as a promising therapeutic strategy, offering the | potential to reduce disease-causing proteins that have | traditionally been challenging to target using conventional

关键词： targeted protein degradation | aptamer | oligonucleotide | disease | therapy | PROTAC | LYTAC | cancer | ocular disorder | drug

3. DEGRADATOR: A Gaming Expedition Into Targeted Protein Degradation Therapies NSTL国家科技图书文献中心

Szulc, Natalia A. | Olchowik, Anna ... - 《Journal of Chemical Education》 - 2025,102(2) - 899～908 - 共10页

摘要： key pathway in cellular protein degradation | introduces the molecular mechanics of targeted protein | understanding of protein* degradation. In quizzes, 59% scored* | degradation, including PROTAC drugs. Through 10 levels of | In an era of rapid scientific advancement, the

关键词： Protein Degradation | Ubiquitin-Proteasome System | PROTAC | Molecular Biology | Medicinal Chemistry | Game-Based Learning

4. Advancing brain tumor therapy: unveiling the potential of PROTACs for targeted protein degradation NSTL国家科技图书文献中心

Ibrahim, Saooda | Khan, Muhammad Umer ... - 《Cytotechnology》 - 2025,77(2) - 共25页

摘要：, particularly brain tumors, is challenged by abnormal protein | The long-term treatment of malignancies | expression and drug resistance. In terms of potency | , selectivity, and overcoming drug resistance, Proteolysis | Targeting Chimeras (PROTACs), a cutting-edge method used

关键词： PROTACS (proteolysis targeting chimeras) | Cancer | Ubiquitin | Proteasome | E3 ligase | Brain tumor | Drug resistance

5. Quantum Mechanics-Based Ranking of Predicted Proteolysis Targeting Chimeras-Mediated Ternary Complexes NSTL国家科技图书文献中心

Stefania,Monteleone | Inaki,Morao ... - 《ACS medicinal chemistry letters》 - 2025,16(3) - 420～427 - 共8页

摘要：Targeted protein degradation has become the | of blocking protein* activity by tightly binding to* | ), bivalent molecules that induce the knockdown of targeted | approaches. We performed local protein–protein* docking* | compatible with the generated protein–protein* docking poses*

关键词： PROTAC | FMO | ternary complex modeling | targeted protein degradation

6. Drug Discovery Approaches to Target E3 Ligases NSTL国家科技图书文献中心

Rodriguez-Gimeno, Al... | Galdeano, Carles - 《Chembiochem》 - 2025,26(1) - n/a～n/a - 共17页

摘要： exploited for targeted* protein degradation (TPD* | and selectivity in protein* degradation. The synergy* | Targeting E3 ligases is a challenging area in | drug discovery. Despite the human genome encoding for | more than 600 E3 ubiquitin ligases, only a handful of

关键词： E3 ligases | Screening technologies | Targeted protein degradation | PROTACs | Undruggable

7. Development of a Buchwald-Hartwig Amination for an Accelerated Library Synthesis of Cereblon Binders NSTL国家科技图书文献中心

Anastasia Lejava | iulianna A.Miseo ... - 《ACS medicinal chemistry letters》 - 2025,16(1) - 89～95 - 共7页

摘要：In recent years,targeted protein degradation | subsequent proteasomal degradation* of target proteins.The* | ligase complex,to initiate degradation* of neosubstrates* | (TPD)has emerged as a powerful therapeutic modality | utilizing both heterobifunctional ligand-directed

关键词： Cereblon Binders | Glutarimides | Alt-Glues | Targeted Protein Degradation

8. Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms NSTL国家科技图书文献中心

Hu, Linghao | Xu, Hesong ... - 《European Journal of Medicinal Chemistry》 - 2025,283 - 117179～117179 - 共17页

摘要： of alkyl primary amine analogs for targeted protein | Nuclear receptor binding SET domain protein* 2* | studies reported the degradation* of PWWP1 domain* | -binding molecules, the degradation* of RE-IIBP which does* | simultaneous degradation* of NSD2-long and RE-IIBP isoforms*

关键词： NSD2 | RE-IIBP | Targeted protein degradation | Multiple myeloma

9. Discovery of novel benzosultam CRBN ligands NSTL国家科技图书文献中心

Hoyeong Park | Santosh Shivanand Ra...... - 《Bulletin of the Korean Chemical Society》 - 2025,46(1) - 48～56 - 共9页

摘要：Targeted protein degradation(TPD)is a | relatively novel drug discovery strategy that could help | break through the limitations of traditional small | molecule inhibitors.While TPD mostly utilizes diverse E3 | ligases to incorporate the ubiquitin-proteasome system

关键词： benzosultam | cereblon | CRBN ligand | IMiDs | targeted protein degradation

10. Targeted Degradation of an ‘Undruggable’ Protein Scaffold to Treat Neuroblastoma NSTL国家科技图书文献中心

Dirk Trauner | Zoe Sessions - 《Synfacts》 - 2025,21(3) - 311～311 - 共1页

摘要：Keywords protein* degradation - N-Myc* | - undruggable target Publication HistoryArticle published | online:25 February 2025© 2025. Thieme. All rights | reserved.Georg Thieme Verlag KGOswald-Hesse-Straße 50, 70469 | Stuttgart, Germany.

摘要：, strategies for targeted* protein degradation (TPD) have been* | degradation and facilitating the recycling of the breakdown | powerful autophagy‐lysosomal degradation* system* | Abstract Autophagy is an evolutionarily | conserved turnover process in eukaryotes, mediating the

关键词： Autophagy | Targeted protein degradation | Small molecule | Macromolecule chimera

摘要：Targeted protein degradation (TPD) has emerged | specificity and affinity for protein* targets - have* | as a promising therapeutic strategy, offering the | potential to reduce disease-causing proteins that have | traditionally been challenging to target using conventional

关键词： targeted protein degradation | aptamer | oligonucleotide | disease | therapy | PROTAC | LYTAC | cancer | ocular disorder | drug

摘要： key pathway in cellular protein degradation | introduces the molecular mechanics of targeted protein | understanding of protein* degradation. In quizzes, 59% scored* | degradation, including PROTAC drugs. Through 10 levels of | In an era of rapid scientific advancement, the

关键词： Protein Degradation | Ubiquitin-Proteasome System | PROTAC | Molecular Biology | Medicinal Chemistry | Game-Based Learning

摘要：, particularly brain tumors, is challenged by abnormal protein | The long-term treatment of malignancies | expression and drug resistance. In terms of potency | , selectivity, and overcoming drug resistance, Proteolysis | Targeting Chimeras (PROTACs), a cutting-edge method used

关键词： PROTACS (proteolysis targeting chimeras) | Cancer | Ubiquitin | Proteasome | E3 ligase | Brain tumor | Drug resistance

摘要：Targeted protein degradation has become the | of blocking protein* activity by tightly binding to* | ), bivalent molecules that induce the knockdown of targeted | approaches. We performed local protein–protein* docking* | compatible with the generated protein–protein* docking poses*

关键词： PROTAC | FMO | ternary complex modeling | targeted protein degradation

摘要： exploited for targeted* protein degradation (TPD* | and selectivity in protein* degradation. The synergy* | Targeting E3 ligases is a challenging area in | drug discovery. Despite the human genome encoding for | more than 600 E3 ubiquitin ligases, only a handful of

关键词： E3 ligases | Screening technologies | Targeted protein degradation | PROTACs | Undruggable

摘要：In recent years,targeted protein degradation | subsequent proteasomal degradation* of target proteins.The* | ligase complex,to initiate degradation* of neosubstrates* | (TPD)has emerged as a powerful therapeutic modality | utilizing both heterobifunctional ligand-directed

关键词： Cereblon Binders | Glutarimides | Alt-Glues | Targeted Protein Degradation

摘要： of alkyl primary amine analogs for targeted protein | Nuclear receptor binding SET domain protein* 2* | studies reported the degradation* of PWWP1 domain* | -binding molecules, the degradation* of RE-IIBP which does* | simultaneous degradation* of NSD2-long and RE-IIBP isoforms*

关键词： NSD2 | RE-IIBP | Targeted protein degradation | Multiple myeloma

摘要：Targeted protein degradation(TPD)is a | relatively novel drug discovery strategy that could help | break through the limitations of traditional small | molecule inhibitors.While TPD mostly utilizes diverse E3 | ligases to incorporate the ubiquitin-proteasome system

关键词： benzosultam | cereblon | CRBN ligand | IMiDs | targeted protein degradation

摘要：Keywords protein* degradation - N-Myc* | - undruggable target Publication HistoryArticle published | online:25 February 2025© 2025. Thieme. All rights | reserved.Georg Thieme Verlag KGOswald-Hesse-Straße 50, 70469 | Stuttgart, Germany.

关键词： protein degradation | N-Myc | undruggable target

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：, strategies for targeted protein degradation (TPD) have been | degradation and facilitating the recycling of the breakdown | powerful autophagy‐lysosomal degradation system | Abstract Autophagy is an evolutionarily | conserved turnover process in eukaryotes, mediating the

关键词： Autophagy | Targeted protein degradation | Small molecule | Macromolecule chimera

摘要：Targeted protein degradation (TPD) has emerged | specificity and affinity for protein targets - have | as a promising therapeutic strategy, offering the | potential to reduce disease-causing proteins that have | traditionally been challenging to target using conventional

关键词： targeted protein degradation | aptamer | oligonucleotide | disease | therapy | PROTAC | LYTAC | cancer | ocular disorder | drug

摘要： key pathway in cellular protein degradation | introduces the molecular mechanics of targeted protein | understanding of protein degradation. In quizzes, 59% scored | degradation, including PROTAC drugs. Through 10 levels of | In an era of rapid scientific advancement, the

关键词： Protein Degradation | Ubiquitin-Proteasome System | PROTAC | Molecular Biology | Medicinal Chemistry | Game-Based Learning

摘要：, particularly brain tumors, is challenged by abnormal protein | The long-term treatment of malignancies | expression and drug resistance. In terms of potency | , selectivity, and overcoming drug resistance, Proteolysis | Targeting Chimeras (PROTACs), a cutting-edge method used

关键词： PROTACS (proteolysis targeting chimeras) | Cancer | Ubiquitin | Proteasome | E3 ligase | Brain tumor | Drug resistance

摘要：Targeted protein degradation has become the | of blocking protein activity by tightly binding to | ), bivalent molecules that induce the knockdown of targeted | approaches. We performed local protein–protein docking | compatible with the generated protein–protein docking poses

关键词： PROTAC | FMO | ternary complex modeling | targeted protein degradation

摘要： exploited for targeted protein degradation (TPD | and selectivity in protein degradation. The synergy | Targeting E3 ligases is a challenging area in | drug discovery. Despite the human genome encoding for | more than 600 E3 ubiquitin ligases, only a handful of

关键词： E3 ligases | Screening technologies | Targeted protein degradation | PROTACs | Undruggable

摘要：In recent years,targeted protein degradation | subsequent proteasomal degradation of target proteins.The | ligase complex,to initiate degradation of neosubstrates | (TPD)has emerged as a powerful therapeutic modality | utilizing both heterobifunctional ligand-directed

关键词： Cereblon Binders | Glutarimides | Alt-Glues | Targeted Protein Degradation

摘要： of alkyl primary amine analogs for targeted protein | Nuclear receptor binding SET domain protein 2 | studies reported the degradation of PWWP1 domain | -binding molecules, the degradation of RE-IIBP which does | simultaneous degradation of NSD2-long and RE-IIBP isoforms

关键词： NSD2 | RE-IIBP | Targeted protein degradation | Multiple myeloma

摘要：Targeted protein degradation(TPD)is a | relatively novel drug discovery strategy that could help | break through the limitations of traditional small | molecule inhibitors.While TPD mostly utilizes diverse E3 | ligases to incorporate the ubiquitin-proteasome system

关键词： benzosultam | cereblon | CRBN ligand | IMiDs | targeted protein degradation

摘要：Keywords protein degradation - N-Myc | - undruggable target Publication HistoryArticle published | online:25 February 2025© 2025. Thieme. All rights | reserved.Georg Thieme Verlag KGOswald-Hesse-Straße 50, 70469 | Stuttgart, Germany.

关键词： protein degradation | N-Myc | undruggable target

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：, strategies for targeted* protein degradation (TPD) have been* | degradation and facilitating the recycling of the breakdown | powerful autophagy‐lysosomal degradation* system* | Abstract Autophagy is an evolutionarily | conserved turnover process in eukaryotes, mediating the

摘要：Targeted protein degradation (TPD) has emerged | specificity and affinity for protein* targets - have* | as a promising therapeutic strategy, offering the | potential to reduce disease-causing proteins that have | traditionally been challenging to target using conventional

摘要： key pathway in cellular protein degradation | introduces the molecular mechanics of targeted protein | understanding of protein* degradation. In quizzes, 59% scored* | degradation, including PROTAC drugs. Through 10 levels of | In an era of rapid scientific advancement, the

摘要：Targeted protein degradation has become the | of blocking protein* activity by tightly binding to* | ), bivalent molecules that induce the knockdown of targeted | approaches. We performed local protein–protein* docking* | compatible with the generated protein–protein* docking poses*

摘要： exploited for targeted* protein degradation (TPD* | and selectivity in protein* degradation. The synergy* | Targeting E3 ligases is a challenging area in | drug discovery. Despite the human genome encoding for | more than 600 E3 ubiquitin ligases, only a handful of

摘要：In recent years,targeted protein degradation | subsequent proteasomal degradation* of target proteins.The* | ligase complex,to initiate degradation* of neosubstrates* | (TPD)has emerged as a powerful therapeutic modality | utilizing both heterobifunctional ligand-directed

摘要： of alkyl primary amine analogs for targeted protein | Nuclear receptor binding SET domain protein* 2* | studies reported the degradation* of PWWP1 domain* | -binding molecules, the degradation* of RE-IIBP which does* | simultaneous degradation* of NSD2-long and RE-IIBP isoforms*

摘要：Keywords protein* degradation - N-Myc* | - undruggable target Publication HistoryArticle published | online:25 February 2025© 2025. Thieme. All rights | reserved.Georg Thieme Verlag KGOswald-Hesse-Straße 50, 70469 | Stuttgart, Germany.