NSTL国家科技图书文献中心

1. Wild-Type TP53 Predicts Poor Prognosis in Lower-Grade Glioma via TP53-CXCL14-GATA3 Axis NSTL国家科技图书文献中心

El-Arabey, Amr Ahmed | Alkhalil, Samia S.... - 《Journal of Molecular Neuroscience》 - 2025,75(2) - Article: 37～Article: 37 - 共12页

摘要： (TP53) regulates or promotes DNA damage and repair via | stability pathways. However, the clinical role of TP53 | (TCGA) of LGG patients to see if TP53* status affects* | patients is wild-type TP53, which is related to poor | patients, wild-type TP53* controls prognostic microRNAs*

关键词： LGG | TP53 | CXCL14 | GATA3 | Has-miR-10a-3p | Has-miR-155-5p

2. TP53 -Mutated Acute Myeloid Leukemia: Review of Treatment and Challenges NSTL国家科技图书文献中心

Ghimire, Bipin | Zimmer, Markie ... - 《European Journal of Haematology》 - 2025,114(6) - 924～937 - 共14页

摘要：) harboring mutations in TP53* (TP53-MT) have poor responses* | . Despite the recognition of variant TP53* as an adverse* | treatments. We present the case of a patient with TP53-MT | , focusing on outcomes for patients with TP53-MT AML. The | heterogeneous TP53-MT genetic background and the challenges in

关键词： acute myeloid leukemia | myelodysplasia | p53 | TP53

3. Endometrial carcinomas with ambiguous histology often harbor TP53 mutations NSTL国家科技图书文献中心

Davidson, Ben | Lande, Karin Teien ... - 《Virchows Archiv》 - 2025,486(4) - 697～705 - 共9页

摘要： instability. Fourteen tumors (78%) harbored TP53* mutations* | tumors with TP53* mutation who concomitantly had MSI or* | is dominated by TP53* mutations and the absence of* | The objective of the present study was to | characterize the molecular features of endometrial carcinomas

关键词： Ambiguous endometrial carcinoma | Whole-exome sequencing | TP53 | Survival

4. Clinicopathologic Features of Breast Tumors in Germline TP53 Variant-Associated Li-Fraumeni Syndrome NSTL国家科技图书文献中心

Narasimhamurthy, Moh... | Le, Anh ... - 《American Journal of Surgical Pathology》 - 2025,49(3) - 195～205 - 共11页

摘要：We present one of the largest cohorts of TP53 | significant correlation between the type of TP53* PGVs and* | . To conclude, breast cancer in carriers of TP53* PGVs* | germline TP53-mutated breast cancers. | -pathogenic germline variants (PGVs) associated with

关键词： Li-Fraumeni syndrome | breast | germline | p53 | TP53

5. Somatic co‐alteration signatures are prognostic in high‐grade TP53‐mutated myeloid neoplasms NSTL国家科技图书文献中心

Emily O. Symes | Peng Wang ... - 《British Journal of Haematology》 - 2025,206(4) - 1103～1108 - 共6页

摘要：‐occurring somatic mutations in TP53‐mutated myeloid | high‐grade TP53‐mutated myeloid neoplasm cohort. | Summary To assess the relevance of co | neoplasms with ≥10% blasts, we pooled 325 individuals from | 10 centres. We focused on comparing three published

关键词： co‐mutations | outcomes | pathology | response | TP53

6. Impact of TP53 Mutation Status in Elderly AML Patients When Adding All- Trans Retinoic Acid or Valproic Acid to Decitabine NSTL国家科技图书文献中心

Bresser, Helena | Schmoor, Claudia ... - 《European Journal of Haematology》 - 2025,114(2) - 231～237 - 共7页

摘要： the predictive impact of TP53* status. Despite a* | completely negated, in TP53-mutated patients. Indeed, 2 out | of 14 TP53-mutated patients (14%) randomized to a | In a randomized phase II trial (AMLSG 14-09 | , NCT00867672) of elderly, newly diagnosed AML patients, ATRA

关键词： AML | ATRA | epigenetics | HMA | TP53

7. Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant-Like Behavior NSTL国家科技图书文献中心

Montilla-Rojo, Joaqu... | Eleveld, Thomas F.... - 《Advanced Biology》 - 2025,9(4) - 共11页

摘要： suppressor TP53, suspected to confer a growth-advantage to | downstream applications is yet to be elucidated. Here, TP53 | results indicate that common TP53-depleting mutations in | Human pluripotent stem cells (hPSCs) tend to | acquire genetic aberrations upon culture in vitro

关键词： genetic aberration | human germ cell tumor | human pluripotent stem cell | malignancy | pluripotency | TP53

8. Genetically Distinct Acute Megakaryoblastic Leukemia following Low Hypodiploid B-Lymphoblastic Leukemia linked by TP53 Mutation NSTL国家科技图书文献中心

Harris, Jaryse C. | Schubert, Jeffrey ... - 《Pediatric and developmental pathology》 - 2025,28(3) - 214～219 - 共6页

摘要： AMKL, however, showed an identical TP53* mutation by* | constitutional TP53* mutation or had a somatic mutation in a* | TP53-mutant tumors, as they may develop multiple | We report a case of acute myeloid leukemia | with megakaryoblastic differentiation (AMKL) that

关键词： acute megakaryoblastic leukemia | low hypodiploid B-lymphoblastic leukemia | TP53 mutation | hematopathology | molecular pathology | molecular oncology

9. Anti-Cancer Bioactive Peptide Induces Apoptosis in Gastric Cancer Cells through TP53 Signaling Cascade NSTL国家科技图书文献中心

Suyila, Qimuge | Li, Xian ... - 《Protein and peptide letters》 - 2025,32(3) - 194～205 - 共12页

摘要： expression of TP53, TP63, and TP73 in cancer cells, as well | expression of TP53, TP63, and TP73 increased in all cell | by inducing apoptosis through the TP53* signaling* | cascade, upregulating TP53, TP63, and TP73 and their | the TP53* signaling cascade. This project provides a*

关键词： Chemotherapy | anti-cancer bioactive peptide | differentiation | human gastric cancer cells | tumor suppressor gene | TP53 signaling.10-Sep-2024

10. Prediction of EGFR-TP53 genes co-mutations in patients with lung adenocarcinoma (LUAD) by 18 F-FDG PET/CT radiomics NSTL国家科技图书文献中心

Li, Shuheng | Hu, Yujing ... - 《Clinical & translational oncology》 - 2025,27(4) - 1506～1515 - 共10页

摘要：) and TP53* in LUAD. Methods A cohort of 150 LUAD* | known mutation status of EGFR and TP53* were collected* | TP53, with AUC equal to 0.850 in the training set | Purpose This retrospective study was | undertaken to assess the predictive efficacy of 18F-FDG PET

摘要： (TP53) regulates or promotes DNA damage and repair via | stability pathways. However, the clinical role of TP53 | (TCGA) of LGG patients to see if TP53* status affects* | patients is wild-type TP53, which is related to poor | patients, wild-type TP53* controls prognostic microRNAs*

关键词： LGG | TP53 | CXCL14 | GATA3 | Has-miR-10a-3p | Has-miR-155-5p

关键词： acute myeloid leukemia | myelodysplasia | p53 | TP53

摘要： instability. Fourteen tumors (78%) harbored TP53* mutations* | tumors with TP53* mutation who concomitantly had MSI or* | is dominated by TP53* mutations and the absence of* | The objective of the present study was to | characterize the molecular features of endometrial carcinomas

关键词： Ambiguous endometrial carcinoma | Whole-exome sequencing | TP53 | Survival

摘要：We present one of the largest cohorts of TP53 | significant correlation between the type of TP53* PGVs and* | . To conclude, breast cancer in carriers of TP53* PGVs* | germline TP53-mutated breast cancers. | -pathogenic germline variants (PGVs) associated with

关键词： Li-Fraumeni syndrome | breast | germline | p53 | TP53

摘要：‐occurring somatic mutations in TP53‐mutated myeloid | high‐grade TP53‐mutated myeloid neoplasm cohort. | Summary To assess the relevance of co | neoplasms with ≥10% blasts, we pooled 325 individuals from | 10 centres. We focused on comparing three published

关键词： co‐mutations | outcomes | pathology | response | TP53

摘要： the predictive impact of TP53* status. Despite a* | completely negated, in TP53-mutated patients. Indeed, 2 out | of 14 TP53-mutated patients (14%) randomized to a | In a randomized phase II trial (AMLSG 14-09 | , NCT00867672) of elderly, newly diagnosed AML patients, ATRA

关键词： AML | ATRA | epigenetics | HMA | TP53

摘要： suppressor TP53, suspected to confer a growth-advantage to | downstream applications is yet to be elucidated. Here, TP53 | results indicate that common TP53-depleting mutations in | Human pluripotent stem cells (hPSCs) tend to | acquire genetic aberrations upon culture in vitro

关键词： genetic aberration | human germ cell tumor | human pluripotent stem cell | malignancy | pluripotency | TP53

摘要： AMKL, however, showed an identical TP53* mutation by* | constitutional TP53* mutation or had a somatic mutation in a* | TP53-mutant tumors, as they may develop multiple | We report a case of acute myeloid leukemia | with megakaryoblastic differentiation (AMKL) that

关键词： acute megakaryoblastic leukemia | low hypodiploid B-lymphoblastic leukemia | TP53 mutation | hematopathology | molecular pathology | molecular oncology

摘要： expression of TP53, TP63, and TP73 in cancer cells, as well | expression of TP53, TP63, and TP73 increased in all cell | by inducing apoptosis through the TP53* signaling* | cascade, upregulating TP53, TP63, and TP73 and their | the TP53* signaling cascade. This project provides a*

关键词： Chemotherapy | anti-cancer bioactive peptide | differentiation | human gastric cancer cells | tumor suppressor gene | TP53 signaling.10-Sep-2024

摘要：) and TP53* in LUAD. Methods A cohort of 150 LUAD* | known mutation status of EGFR and TP53* were collected* | TP53, with AUC equal to 0.850 in the training set | Purpose This retrospective study was | undertaken to assess the predictive efficacy of 18F-FDG PET

关键词： EGFR | TP53 | Radiomics | PET/CT | LUAD

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： (TP53) regulates or promotes DNA damage and repair via | stability pathways. However, the clinical role of TP53 | (TCGA) of LGG patients to see if TP53 status affects | patients is wild-type TP53, which is related to poor | patients, wild-type TP53 controls prognostic microRNAs

关键词： LGG | TP53 | CXCL14 | GATA3 | Has-miR-10a-3p | Has-miR-155-5p

关键词： acute myeloid leukemia | myelodysplasia | p53 | TP53

摘要： instability. Fourteen tumors (78%) harbored TP53 mutations | tumors with TP53 mutation who concomitantly had MSI or | is dominated by TP53 mutations and the absence of | The objective of the present study was to | characterize the molecular features of endometrial carcinomas

关键词： Ambiguous endometrial carcinoma | Whole-exome sequencing | TP53 | Survival

摘要：We present one of the largest cohorts of TP53 | significant correlation between the type of TP53 PGVs and | . To conclude, breast cancer in carriers of TP53 PGVs | germline TP53-mutated breast cancers. | -pathogenic germline variants (PGVs) associated with

关键词： Li-Fraumeni syndrome | breast | germline | p53 | TP53

摘要：‐occurring somatic mutations in TP53‐mutated myeloid | high‐grade TP53‐mutated myeloid neoplasm cohort. | Summary To assess the relevance of co | neoplasms with ≥10% blasts, we pooled 325 individuals from | 10 centres. We focused on comparing three published

关键词： co‐mutations | outcomes | pathology | response | TP53

摘要： the predictive impact of TP53 status. Despite a | completely negated, in TP53-mutated patients. Indeed, 2 out | of 14 TP53-mutated patients (14%) randomized to a | In a randomized phase II trial (AMLSG 14-09 | , NCT00867672) of elderly, newly diagnosed AML patients, ATRA

关键词： AML | ATRA | epigenetics | HMA | TP53

摘要： suppressor TP53, suspected to confer a growth-advantage to | downstream applications is yet to be elucidated. Here, TP53 | results indicate that common TP53-depleting mutations in | Human pluripotent stem cells (hPSCs) tend to | acquire genetic aberrations upon culture in vitro

关键词： genetic aberration | human germ cell tumor | human pluripotent stem cell | malignancy | pluripotency | TP53

摘要： AMKL, however, showed an identical TP53 mutation by | constitutional TP53 mutation or had a somatic mutation in a | TP53-mutant tumors, as they may develop multiple | We report a case of acute myeloid leukemia | with megakaryoblastic differentiation (AMKL) that

关键词： acute megakaryoblastic leukemia | low hypodiploid B-lymphoblastic leukemia | TP53 mutation | hematopathology | molecular pathology | molecular oncology

摘要： expression of TP53, TP63, and TP73 in cancer cells, as well | expression of TP53, TP63, and TP73 increased in all cell | by inducing apoptosis through the TP53 signaling | cascade, upregulating TP53, TP63, and TP73 and their | the TP53 signaling cascade. This project provides a

关键词： Chemotherapy | anti-cancer bioactive peptide | differentiation | human gastric cancer cells | tumor suppressor gene | TP53 signaling.10-Sep-2024

摘要：) and TP53 in LUAD. Methods A cohort of 150 LUAD | known mutation status of EGFR and TP53 were collected | TP53, with AUC equal to 0.850 in the training set | Purpose This retrospective study was | undertaken to assess the predictive efficacy of 18F-FDG PET

关键词： EGFR | TP53 | Radiomics | PET/CT | LUAD

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： (TP53) regulates or promotes DNA damage and repair via | stability pathways. However, the clinical role of TP53 | (TCGA) of LGG patients to see if TP53* status affects* | patients is wild-type TP53, which is related to poor | patients, wild-type TP53* controls prognostic microRNAs*

摘要： instability. Fourteen tumors (78%) harbored TP53* mutations* | tumors with TP53* mutation who concomitantly had MSI or* | is dominated by TP53* mutations and the absence of* | The objective of the present study was to | characterize the molecular features of endometrial carcinomas

摘要：We present one of the largest cohorts of TP53 | significant correlation between the type of TP53* PGVs and* | . To conclude, breast cancer in carriers of TP53* PGVs* | germline TP53-mutated breast cancers. | -pathogenic germline variants (PGVs) associated with

摘要： the predictive impact of TP53* status. Despite a* | completely negated, in TP53-mutated patients. Indeed, 2 out | of 14 TP53-mutated patients (14%) randomized to a | In a randomized phase II trial (AMLSG 14-09 | , NCT00867672) of elderly, newly diagnosed AML patients, ATRA

摘要： AMKL, however, showed an identical TP53* mutation by* | constitutional TP53* mutation or had a somatic mutation in a* | TP53-mutant tumors, as they may develop multiple | We report a case of acute myeloid leukemia | with megakaryoblastic differentiation (AMKL) that

摘要： expression of TP53, TP63, and TP73 in cancer cells, as well | expression of TP53, TP63, and TP73 increased in all cell | by inducing apoptosis through the TP53* signaling* | cascade, upregulating TP53, TP63, and TP73 and their | the TP53* signaling cascade. This project provides a*

摘要：) and TP53* in LUAD. Methods A cohort of 150 LUAD* | known mutation status of EGFR and TP53* were collected* | TP53, with AUC equal to 0.850 in the training set | Purpose This retrospective study was | undertaken to assess the predictive efficacy of 18F-FDG PET