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1. STING activation and overcoming the challenges associated with STING agonists using ADC (antibody-drug conjugate) and other delivery systems NSTL国家科技图书文献中心

Vasiyani, Hitesh |  Wadhwa, Bhumika -  《Cellular Signalling》 - 2025,128 - 共12页

摘要: synthase)-STING (stimulator of interferon genes) pathway | . Exploitation of host immunity against cancer using STING |  STING agonist. Activation of STING leads to activation |  (Cyclicdinucleotide) STING agonists. Moreover, chemically modified |  CDNs and completely synthetic STING agonists have
关键词: STING agonists delivery |  STING activation in cancer |  Cancer immunotherpy

2. A trinity STING-activating nanoparticle harnesses cancer cell STING machinery for enhanced immunotherapy NSTL国家科技图书文献中心

Xia, Yanming |  Shi, Bo... -  《Journal of Controlled Release》 - 2025,377 - 256~266 - 共11页

摘要:The cGAS-STING axis is a promising therapeutic |  STING signaling in the host, especially within antigen |  microenvironment. The cGAS-STING cascade is also present within | . Herein, we develop a trinity STING-activating |  porphyrin to awaken autologous STING signaling in cancer
关键词: Cancer immunotherapy |  cGAS-STING |  Coordination nanoparticle |  Mitochondrial DNA

3. The STING signaling pathways and bacterial infection NSTL国家科技图书文献中心

You, Jiayi |  Xu, Ailing... -  《Apoptosis》 - 2025,30(1/2) - 389~400 - 共12页

摘要: interferon genes (STING) is a PRR that binds with cyclic |  regulated cell death. Currently, drugs targeting the STING |  significant immunomodulatory functions of STING in the |  summarizes the research progress on STING signaling |  as the novel functions of STING modulators, aiming
关键词: STING |  cGAS |  Cyclic dinucleotides |  Bacterial infection |  Modulator

4. Therapeutic targeting of cGAS-STING pathway in lung cancer NSTL国家科技图书文献中心

Wang, Jinli |  Xing, Lumin -  《Cell biology international.》 - 2025,49(2) - 129~138 - 共10页

摘要: (cGAS-STING) is an essential cytosolic DNA sensor that |  response. The cGAS-STING pathway has great anticancer |  cGAS-STING signals. So, it is clear that a |  biotherapy and the functioning of the cGAS-STING pathway | . Several STING agonists with promising outcomes have been
关键词: lung cancer |  STING |  STING agonists |  tumor immune microenvironment

5. Development of STING probes and visualization of STING in multiple tumor types NSTL国家科技图书文献中心

Liu, Huanhuan |  Liu, Jia... -  《European Journal of Nuclear Medicine and Molecular Imaging》 - 2025,52(2) - 401~415 - 共15页

摘要: (STING) is a critical component of the innate immune |  visualizing STING is highly valuable for STING-related |  tumor STING expression. Methods We investigated the in |  STING-expressing tumors (B16F10, MC38, and Panc02 | ) with STING-targeted radioprobe ([18F]F-CRI1). The
关键词: Stimulator of interferon genes |  F-18-labeled probe |  Acridone derivatives |  STING visualization |  Immunoimaging

6. STING inhibitors and degraders: Potential therapeutic agents in inflammatory diseases NSTL国家科技图书文献中心

Wu, Kerong |  Xu, Yiwen... -  《European Journal of Medicinal Chemistry》 - 2025,291 - 117632~117632 - 共15页

摘要:The regulation of the STING (stimulator of |  provides an overview of the structure of STING and |  synthase (cGAS)-STING pathway is associated with various |  targeting STING inhibition or degradation can alleviate | . Emerging strategies include inhibiting STING expression
关键词: STING |  Inhibitors and degraders |  Inflammatory diseases

7. Cordycepin ameliorates autoimmunity by promoting STING degradation via autophagy pathway NSTL国家科技图书文献中心

Yang, Daidi |  Peng, Niannian... -  《British journal of pharmacology.》 - 2025,182(7) - 1546~1560 - 共15页

摘要: response cGAMP interactor 1 (STING), a central hub |  protein of cyclic GMP-AMP synthase (cGAS)-STING |  indicate that excessive activation of STING is strongly |  that negatively regulate STING might greatly |  following cGAS-STING signalling activation. Importantly
关键词: autoimmune disease |  autophagy |  cordycepin |  innate immunity |  STING

8. STING Facilitates Vascular Calcification via p-STAT1/NLRP3 Signal NSTL国家科技图书文献中心

Lihe Lu |  Xiaoyu Liu... -  《The FASEB Journal》 - 2025,39(7) - e70530~e70530 - 共14页

摘要: exists. The cGAS-STING signaling participates in |  the cGAS-STING signaling. However, it remains poorly |  understood whether STING regulates vascular calcification |  that the expression of STING was elevated during |  vascular calcification. STING knockdown or
关键词: DNA damage; NLRP3; STAT1; STING; cGAS; vascular calcification.

9. Amplifying the Antitumor Effect of STING Agonist MSA-2 by Phospholipid Nanoparticles Delivering STING mRNA and Copper-Modified MSA-2 Combination NSTL国家科技图书文献中心

Zhou, Peng |  Wang, Mo... -  《ACS applied materials & interfaces》 - 2025,17(17) - 24820~24829 - 共10页

摘要:STING activation is a promising application | , MSA-2 as an oral STING agonist is discovered to have |  nanoparticles delivering STING mRNA and copper-modified MSA-2 |  nanoparticle (1AP24) for delivering STING mRNA, increasing |  the expression of STING protein to bind more MSA-2
关键词: immunotherapy |  stimulator of interferon genes (STING) |  STING agonist |  MSA-2 |  phospholipid nanoparticles |  mRNA delivery

10. STING in cancer immunoediting: Modeling tumor-immune dynamics throughout cancer development NSTL国家科技图书文献中心

Zhang, Xiao |  Chen, Yan... -  《Cancer letters》 - 2025,612 - Article 217410~Article 217410 - 共19页

摘要: immune cells in this process. The STING molecule, a |  has shown that the activation of STING signaling has |  escape. In this review, we elucidate the roles of STING |  the dichotomous effects of STING agonists in the |  understanding of the sophisticated roles of STING signaling
关键词: STING |  Cancer immunoediting |  STING agonists |  Cancer immunotherapy
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