NSTL国家科技图书文献中心

1. An antibody against human interleukin-2 showing minimal binding to neonatal Fc receptor: Potent anti-tumor activity and reduced systemic toxicity in mice NSTL国家科技图书文献中心

Lv, Yunying | Chen, Jianhe ... - 《European Journal of Pharmacology》 - 2025,987 - 177159～177159 - 共10页

摘要： xenografts (CT26, MC38) in immunocompetent mice. Co | MC38 xenografts downregulated PD-1 and CD44, while | -PD-1 antibody to slow growth of MC38* xenografts* | The anti-tumor efficacy of immune checkpoint | inhibitors can be enhanced by combining them with

关键词： IL-2 | IL-2/Antibody complex | Cytokine-antibody complex | Immunotherapy

2. Combinational delivery of TLR4 and TLR7/8 agonist enhanced the therapeutic efficacy of immune checkpoint inhibitors to colon tumor NSTL国家科技图书文献中心

Wang, Mengjiao | Wan, Quan ... - 《Molecular and Cellular Biochemistry》 - 2025,480(1) - 445～458 - 共14页

摘要： therapeutic strategy by using CT26 and MC38* mouse colon* | effective in eradicating CT26 and MC38* colon cancer and* | Immunotherapy is regarded as a potent cancer | treatment, with DC vaccines playing a crucial role | . Although clinical trials have demonstrated the safety and

关键词： HMGN1 | R848 | alpha-TNFR2 | Immunosuppression | Combination immunotherapy

3. Novel Peptide-Based 68 Ga-Labeled Radiotracer for Preclinical Studies of TIM3 Expression NSTL国家科技图书文献中心

Tao, Jinping | Wang, Fei ... - 《Molecular pharmaceutics》 - 2025,22(1) - 270～283 - 共14页

摘要： was injected in the MC38* model (colorectal cancer in* | other molecular probes, and in the MC38* model, similar* | showed that A549TIM3, MC38, and CCRCC tumor tissues had | T-cell immunoglobulin and mucin domain-3 (TIM3 | ) is an immune checkpoint that plays a negative

关键词： T-cell immunoglobulin and mucin domain-3 | peptides | radioactive tracer | micro-PET/CT imaging | immunecheckpoint inhibitor

4. Development of Cyclic Peptide-Based Radiotracers for uPAR NSTL国家科技图书文献中心

Xingkai Wang | Xu Zhang ... - 《ChemMedChem》 - 2025,20(10) - e202500061～6 - 共6页

摘要：, and favorable pharmacokinetics in an MC38* tumor* | The urokinase plasminogen activator(uPA)system | has garnered attention as a promising biomarker | , with the uPA receptor(uPAR)playing a central role in | system regulation and demonstrating strong associations

关键词： Urokinase-type plasminogen activator receptor | Cyclic peptide | PET imaging

5. 5-Fluorouracil-methotrexate conjugate enhances the efficacy of 5-fluorouracil in colorectal cancer therapy NSTL国家科技图书文献中心

Zhao, Siyuan | Wang, Tiansi ... - 《Investigational new drugs.》 - 2025,43(1) - 30～41 - 共12页

摘要： MC38, HT29, and 4T1 cells, respectively. In vivo, MF | To extend the short half-life of fluorouracil | (Fu), enhance its tumor targeting, improve efficacy | , and reduce side effects, providing a new approach | for colorectal cancer treatment. Fluorouracil was

关键词： 5-Fluorouracil | Methotrexate | Drug conjugate | Cyclodextrin

6. A trinity STING-activating nanoparticle harnesses cancer cell STING machinery for enhanced immunotherapy NSTL国家科技图书文献中心

Xia, Yanming | Shi, Bo ... - 《Journal of Controlled Release》 - 2025,377 - 256～266 - 共11页

摘要： CMTP demonstrates robust efficacy in both hot MC38 | The cGAS-STING axis is a promising therapeutic | target against cancer. However, most activators require | STING signaling in the host, especially within antigen | -presenting cells, which are rare in a cold tumor

关键词： Cancer immunotherapy | cGAS-STING | Coordination nanoparticle | Mitochondrial DNA

7. Development of STING probes and visualization of STING in multiple tumor types NSTL国家科技图书文献中心

Liu, Huanhuan | Liu, Jia ... - 《European Journal of Nuclear Medicine and Molecular Imaging》 - 2025,52(2) - 401～415 - 共15页

摘要： STING-expressing tumors (B16F10, MC38, and Panc02 | Purpose The stimulator of interferon genes | (STING) is a critical component of the innate immune | system and plays a pivotal role in tumor immunotherapy | . Developing non-invasive in vivo diagnostic methods for

关键词： Stimulator of interferon genes | F-18-labeled probe | Acridone derivatives | STING visualization | Immunoimaging

8. Specific imaging of CD8+T-Cell dynamics with a nanobody radiotracer against human CD8β NSTL国家科技图书文献中心

De Groof, Timo W. M. | Lauwers, Yoline ... - 《European Journal of Nuclear Medicine and Molecular Imaging》 - 2025,52(1) - 193～207 - 共15页

摘要： imaging of CD8+ T cells in MC38* tumor-bearing mice* | PurposeWhile immunotherapy has revolutionized | the oncology field, variations in therapy | responsiveness limit the broad applicability of these therapies | . Diagnostic imaging of immune cell, and specifically CD8+ T

关键词： Immuno-imaging | Nuclear imaging | Nanobodies | T-cell dynamics

9. Prolonged interval hypofractionated radiotherapy facilitates better antitumor immunity NSTL国家科技图书文献中心

Xiao, Jie | Shao, Shilong ... - 《Radiotherapy and oncology》 - 2025,203 - Article 110664～Article 110664 - 共9页

摘要：: The mouse MC38* colon cancer model was utilized* | Purpose: To evaluate the impact of | hypofractionated radiotherapy (Hypo-RT) with different | interfraction intervals on tumor growth, immune response, and | synergistic effects with anti-PD-1 immunotherapy. Methods

关键词： Hypofractionated radiotherapy | Antitumor Immunity

10. Investigating immune-modulatory function of α-glucopyranose-rich compound polysaccharides by MC38-N4/OT-I co-culture system NSTL国家科技图书文献中心

Yongzhao Xu | Tianxiong Xu ... - 《International Journal of Biological Macromolecules: Structure, Function and Interactions》 - 2024,278(Pt.3) - 134941-1～134941-9 - 共9页

摘要： compounds, the MC38-N4/OT-I co-culture system was | % ± 1.23 %, p < 0.05) in the survival rate of MC38-N4 | The potential antitumor function of | polysaccharides is well accepted, it is unclear whether | polysaccharides have immunoregulatory effect on CD8~+ T

摘要： xenografts (CT26, MC38) in immunocompetent mice. Co | MC38 xenografts downregulated PD-1 and CD44, while | -PD-1 antibody to slow growth of MC38* xenografts* | The anti-tumor efficacy of immune checkpoint | inhibitors can be enhanced by combining them with

关键词： IL-2 | IL-2/Antibody complex | Cytokine-antibody complex | Immunotherapy

摘要： therapeutic strategy by using CT26 and MC38* mouse colon* | effective in eradicating CT26 and MC38* colon cancer and* | Immunotherapy is regarded as a potent cancer | treatment, with DC vaccines playing a crucial role | . Although clinical trials have demonstrated the safety and

关键词： HMGN1 | R848 | alpha-TNFR2 | Immunosuppression | Combination immunotherapy

摘要： was injected in the MC38* model (colorectal cancer in* | other molecular probes, and in the MC38* model, similar* | showed that A549TIM3, MC38, and CCRCC tumor tissues had | T-cell immunoglobulin and mucin domain-3 (TIM3 | ) is an immune checkpoint that plays a negative

关键词： T-cell immunoglobulin and mucin domain-3 | peptides | radioactive tracer | micro-PET/CT imaging | immunecheckpoint inhibitor

摘要：, and favorable pharmacokinetics in an MC38* tumor* | The urokinase plasminogen activator(uPA)system | has garnered attention as a promising biomarker | , with the uPA receptor(uPAR)playing a central role in | system regulation and demonstrating strong associations

关键词： Urokinase-type plasminogen activator receptor | Cyclic peptide | PET imaging

摘要： MC38, HT29, and 4T1 cells, respectively. In vivo, MF | To extend the short half-life of fluorouracil | (Fu), enhance its tumor targeting, improve efficacy | , and reduce side effects, providing a new approach | for colorectal cancer treatment. Fluorouracil was

关键词： 5-Fluorouracil | Methotrexate | Drug conjugate | Cyclodextrin

摘要： CMTP demonstrates robust efficacy in both hot MC38 | The cGAS-STING axis is a promising therapeutic | target against cancer. However, most activators require | STING signaling in the host, especially within antigen | -presenting cells, which are rare in a cold tumor

关键词： Cancer immunotherapy | cGAS-STING | Coordination nanoparticle | Mitochondrial DNA

摘要： STING-expressing tumors (B16F10, MC38, and Panc02 | Purpose The stimulator of interferon genes | (STING) is a critical component of the innate immune | system and plays a pivotal role in tumor immunotherapy | . Developing non-invasive in vivo diagnostic methods for

关键词： Stimulator of interferon genes | F-18-labeled probe | Acridone derivatives | STING visualization | Immunoimaging

摘要： imaging of CD8+ T cells in MC38* tumor-bearing mice* | PurposeWhile immunotherapy has revolutionized | the oncology field, variations in therapy | responsiveness limit the broad applicability of these therapies | . Diagnostic imaging of immune cell, and specifically CD8+ T

关键词： Immuno-imaging | Nuclear imaging | Nanobodies | T-cell dynamics

摘要：: The mouse MC38* colon cancer model was utilized* | Purpose: To evaluate the impact of | hypofractionated radiotherapy (Hypo-RT) with different | interfraction intervals on tumor growth, immune response, and | synergistic effects with anti-PD-1 immunotherapy. Methods

关键词： Hypofractionated radiotherapy | Antitumor Immunity

摘要： compounds, the MC38-N4/OT-I co-culture system was | % ± 1.23 %, p < 0.05) in the survival rate of MC38-N4 | The potential antitumor function of | polysaccharides is well accepted, it is unclear whether | polysaccharides have immunoregulatory effect on CD8~+ T

关键词： α-Glucopyranose-rich compound | polysaccharides | Immunomodulation | MC38-N4/OT-I co-culture system

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： xenografts (CT26, MC38) in immunocompetent mice. Co | MC38 xenografts downregulated PD-1 and CD44, while | -PD-1 antibody to slow growth of MC38 xenografts | The anti-tumor efficacy of immune checkpoint | inhibitors can be enhanced by combining them with

关键词： IL-2 | IL-2/Antibody complex | Cytokine-antibody complex | Immunotherapy

摘要： therapeutic strategy by using CT26 and MC38 mouse colon | effective in eradicating CT26 and MC38 colon cancer and | Immunotherapy is regarded as a potent cancer | treatment, with DC vaccines playing a crucial role | . Although clinical trials have demonstrated the safety and

关键词： HMGN1 | R848 | alpha-TNFR2 | Immunosuppression | Combination immunotherapy

摘要： was injected in the MC38 model (colorectal cancer in | other molecular probes, and in the MC38 model, similar | showed that A549TIM3, MC38, and CCRCC tumor tissues had | T-cell immunoglobulin and mucin domain-3 (TIM3 | ) is an immune checkpoint that plays a negative

关键词： T-cell immunoglobulin and mucin domain-3 | peptides | radioactive tracer | micro-PET/CT imaging | immunecheckpoint inhibitor

摘要：, and favorable pharmacokinetics in an MC38 tumor | The urokinase plasminogen activator(uPA)system | has garnered attention as a promising biomarker | , with the uPA receptor(uPAR)playing a central role in | system regulation and demonstrating strong associations

关键词： Urokinase-type plasminogen activator receptor | Cyclic peptide | PET imaging

摘要： MC38, HT29, and 4T1 cells, respectively. In vivo, MF | To extend the short half-life of fluorouracil | (Fu), enhance its tumor targeting, improve efficacy | , and reduce side effects, providing a new approach | for colorectal cancer treatment. Fluorouracil was

关键词： 5-Fluorouracil | Methotrexate | Drug conjugate | Cyclodextrin

摘要： CMTP demonstrates robust efficacy in both hot MC38 | The cGAS-STING axis is a promising therapeutic | target against cancer. However, most activators require | STING signaling in the host, especially within antigen | -presenting cells, which are rare in a cold tumor

关键词： Cancer immunotherapy | cGAS-STING | Coordination nanoparticle | Mitochondrial DNA

摘要： STING-expressing tumors (B16F10, MC38, and Panc02 | Purpose The stimulator of interferon genes | (STING) is a critical component of the innate immune | system and plays a pivotal role in tumor immunotherapy | . Developing non-invasive in vivo diagnostic methods for

关键词： Stimulator of interferon genes | F-18-labeled probe | Acridone derivatives | STING visualization | Immunoimaging

摘要： imaging of CD8+ T cells in MC38 tumor-bearing mice | PurposeWhile immunotherapy has revolutionized | the oncology field, variations in therapy | responsiveness limit the broad applicability of these therapies | . Diagnostic imaging of immune cell, and specifically CD8+ T

关键词： Immuno-imaging | Nuclear imaging | Nanobodies | T-cell dynamics

摘要：: The mouse MC38 colon cancer model was utilized | Purpose: To evaluate the impact of | hypofractionated radiotherapy (Hypo-RT) with different | interfraction intervals on tumor growth, immune response, and | synergistic effects with anti-PD-1 immunotherapy. Methods

关键词： Hypofractionated radiotherapy | Antitumor Immunity

摘要： compounds, the MC38-N4/OT-I co-culture system was | % ± 1.23 %, p < 0.05) in the survival rate of MC38-N4 | The potential antitumor function of | polysaccharides is well accepted, it is unclear whether | polysaccharides have immunoregulatory effect on CD8~+ T

关键词： α-Glucopyranose-rich compound | polysaccharides | Immunomodulation | MC38-N4/OT-I co-culture system

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： xenografts (CT26, MC38) in immunocompetent mice. Co | MC38 xenografts downregulated PD-1 and CD44, while | -PD-1 antibody to slow growth of MC38* xenografts* | The anti-tumor efficacy of immune checkpoint | inhibitors can be enhanced by combining them with

摘要： therapeutic strategy by using CT26 and MC38* mouse colon* | effective in eradicating CT26 and MC38* colon cancer and* | Immunotherapy is regarded as a potent cancer | treatment, with DC vaccines playing a crucial role | . Although clinical trials have demonstrated the safety and

摘要： was injected in the MC38* model (colorectal cancer in* | other molecular probes, and in the MC38* model, similar* | showed that A549TIM3, MC38, and CCRCC tumor tissues had | T-cell immunoglobulin and mucin domain-3 (TIM3 | ) is an immune checkpoint that plays a negative

摘要：, and favorable pharmacokinetics in an MC38* tumor* | The urokinase plasminogen activator(uPA)system | has garnered attention as a promising biomarker | , with the uPA receptor(uPAR)playing a central role in | system regulation and demonstrating strong associations

摘要： imaging of CD8+ T cells in MC38* tumor-bearing mice* | PurposeWhile immunotherapy has revolutionized | the oncology field, variations in therapy | responsiveness limit the broad applicability of these therapies | . Diagnostic imaging of immune cell, and specifically CD8+ T

摘要：: The mouse MC38* colon cancer model was utilized* | Purpose: To evaluate the impact of | hypofractionated radiotherapy (Hypo-RT) with different | interfraction intervals on tumor growth, immune response, and | synergistic effects with anti-PD-1 immunotherapy. Methods