NSTL国家科技图书文献中心

1. Systematic Mendelian Randomization Exploring Druggable Genes for Hemorrhagic Strokes NSTL国家科技图书文献中心

Yang, Lun-Zhe | Yang, Yong ... - 《Molecular Neurobiology》 - 2025,62(2) - 1359～1372 - 共14页

摘要： analysis to systematically explore the druggable genes | druggable were considered desirable genes. We also | druggable genes with other cardiovascular diseases were | six druggable* genes were associated with hemorrhagic* | genes in hemorrhagic stroke; therefore, we used MR

关键词： Druggable genes | Hemorrhagic strokes | Mendelian randomization | Summary-data-based Mendelian randomization

2. MDMNI-DGD: A novel graph neural network approach for druggable gene discovery based on the integration of multi-omics data and the multi-view network NSTL国家科技图书文献中心

Li J. | Li B.... - 《Computers in Biology and Medicine》 - 2025,185 - Article 109511～Article 109511 - 共10页

摘要： druggable genes is of paramount importance for enhancing | cancer-druggable* genes remains a critical challenge in* | predict and evaluate cancer-druggable* genes. MDMNI-DGD* | discovering potentially druggable* genes. Among more than* | identified 872 potentially druggable* genes. The findings*

关键词： Druggable genes | Graph neural network | Multi-omics data | Multi-view network

3. Genomics-driven integrative analysis highlights immune-related plasma proteins for psychiatric disorders NSTL国家科技图书文献中心

Gong, Weiming | Guo, Ping ... - 《Journal of affective disorders》 - 2025,370 - 124～133 - 共10页

摘要：, eight protein-coding genes* were immune-related, such* | as IRF3, CSK, and ACE, five among 16 druggable | genes were reported to interact with drugs, including | Background: Genome-wide association studies | (GWAS) have identified numerous variants associated

关键词： Psychiatric disorders | Plasma proteins | Proteome-wide association study | Mendelian randomization | Colocalization | Druggable genes

4. Deciphering the genetic underpinnings of neuroticism: A Mendelian randomization study of druggable gene targets NSTL国家科技图书文献中心

Hong, Yanggang | Wang, Yi ... - 《Journal of affective disorders》 - 2025,370 - 147～158 - 共12页

摘要： genes causally linked to neuroticism. To further | interactions between drugs and genes* for drug prediction and* | . Results: The analysis involved a total of 4473 druggable | genes, with two-sample Mendelian randomization (MR | ) identifying 186 genes* that are causally linked to*

关键词： Neuroticism | Mendelian randomization | Drug targets | Genetics

5. Drug repurposing opportunities for breast cancer and seven common subtypes NSTL国家科技图书文献中心

Lin, Yilong | Wang, Songsong ... - 《The Journal of Steroid Biochemistry and Molecular Biology》 - 2025,246 - 106652～106652 - 共12页

摘要： subtypes, we found 29 actionable druggable* genes for* | ) results, we identified 26 genes* for overall breast* | cancer, 25 genes for ER+ breast cancer and 4 genes | Luminal A breast cancer, 2 genes* (IGF2 and TNNT3) for* | HER2 negative breast cancer, and 3 genes* (CASP8*

关键词： Breast cancer | Drug repurposing | Molecular docking

6. KRAS inhibitors: resistance drivers and combinatorial strategies NSTL国家科技图书文献中心

Tamara Isermann | Christine Sers ... - 《Trends in cancer.》 - 2025,11(2) - 91～116 - 共26页

摘要：In 1982, the RAS genes* HRAS and KRAS were* | discovered as the first human cancer genes, with KRAS later | in 2013 by Shokat and colleagues of a druggable | identified as one of the most frequently mutated oncogenes | . Yet, it took nearly 40 years to develop clinically

关键词： KRAS; colorectal carcinoma; drug resistance; non-small cell lung cancer; pancreatic ductal

7. The evaluation of Phenylalanine-tRNA ligase beta unit ( PheT ), as a potential target in Mycobacterium abscessus NSTL国家科技图书文献中心

Xie, Weile | Luo, Dan ... - 《Tuberculosis》 - 2025,152 - 102626～102626 - 共10页

摘要： expression of host genes* in response to PheT gene silencing* | , including genes* involved in the cell cycle, apoptotic* | its silencing may represent a druggable* therapeutic* | Mycobacterium abscessus (M. abscessus) is an | emerging pathogenic mycobacterium that mainly causes

关键词： Mycobacterium abscessus | AARS | PheT | Drug target | CRISPRi

8. Blood Circulating Tumor DNA-based Genomic Profiling and Serial Analysis in Patients With Advanced Biliary Tract Cancer NSTL国家科技图书文献中心

Jo, Hyunji | Park, Younghee ... - 《Anticancer Research》 - 2025,45(4) - 1447～1463 - 共17页

摘要： or druggable* targets in patients with advanced* | to 118 genes* for single- nucleotide variants (SNVs* | ) and insertion or deletions (INDELs), 27 genes* for* | copy number alterations (CNAs), and 10 genes* for* | baseline. The most common genes* altered in ctDNA were*

关键词： Biliary tract cancer | ctDNA | NGS | concordance | high VAF

9. Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes NSTL国家科技图书文献中心

Indira Pla | Botond L. Szabolcs ... - 《International journal of dermatology》 - 2025,64(5) - 870～881 - 共12页

摘要： proteogenomic data to identify druggable* targets and forecast* | of 162 potentially targetable genes. Lastly, we | Abstract Background The utilization of PD1 and | CTLA4 inhibitors has revolutionized the treatment of | malignant melanoma (MM). However, resistance to targeted

关键词： malignant melanoma | skin cancer | ferroptosis | drug target prediction | HDAC | RTK inhibitor

10. Exploring the role of miRNA in diabetic neuropathy: from diagnostics to therapeutics NSTL国家科技图书文献中心

Saha, Priya | Yarra, Sai Sumanjali ... - 《Naunyn-Schmiedeberg's Archives of Pharmacology》 - 2025,398(2) - 1129～1144 - 共16页

摘要： similar to 50% protein-coding genes* through repression* | druggable aspects for promising future therapies for the | Diabetic neuropathy (DN) is one of the major | microvascular complications of diabetes mellitus affecting 50 | % of the diabetic population marred by various unmet

摘要： analysis to systematically explore the druggable genes | druggable were considered desirable genes. We also | druggable genes with other cardiovascular diseases were | six druggable* genes were associated with hemorrhagic* | genes in hemorrhagic stroke; therefore, we used MR

关键词： Druggable genes | Hemorrhagic strokes | Mendelian randomization | Summary-data-based Mendelian randomization

关键词： Druggable genes | Graph neural network | Multi-omics data | Multi-view network

摘要：, eight protein-coding genes* were immune-related, such* | as IRF3, CSK, and ACE, five among 16 druggable | genes were reported to interact with drugs, including | Background: Genome-wide association studies | (GWAS) have identified numerous variants associated

关键词： Psychiatric disorders | Plasma proteins | Proteome-wide association study | Mendelian randomization | Colocalization | Druggable genes

摘要： genes causally linked to neuroticism. To further | interactions between drugs and genes* for drug prediction and* | . Results: The analysis involved a total of 4473 druggable | genes, with two-sample Mendelian randomization (MR | ) identifying 186 genes* that are causally linked to*

关键词： Neuroticism | Mendelian randomization | Drug targets | Genetics

摘要： subtypes, we found 29 actionable druggable* genes for* | ) results, we identified 26 genes* for overall breast* | cancer, 25 genes for ER+ breast cancer and 4 genes | Luminal A breast cancer, 2 genes* (IGF2 and TNNT3) for* | HER2 negative breast cancer, and 3 genes* (CASP8*

关键词： Breast cancer | Drug repurposing | Molecular docking

摘要：In 1982, the RAS genes* HRAS and KRAS were* | discovered as the first human cancer genes, with KRAS later | in 2013 by Shokat and colleagues of a druggable | identified as one of the most frequently mutated oncogenes | . Yet, it took nearly 40 years to develop clinically

关键词： KRAS; colorectal carcinoma; drug resistance; non-small cell lung cancer; pancreatic ductal

摘要： expression of host genes* in response to PheT gene silencing* | , including genes* involved in the cell cycle, apoptotic* | its silencing may represent a druggable* therapeutic* | Mycobacterium abscessus (M. abscessus) is an | emerging pathogenic mycobacterium that mainly causes

关键词： Mycobacterium abscessus | AARS | PheT | Drug target | CRISPRi

摘要： or druggable* targets in patients with advanced* | to 118 genes* for single- nucleotide variants (SNVs* | ) and insertion or deletions (INDELs), 27 genes* for* | copy number alterations (CNAs), and 10 genes* for* | baseline. The most common genes* altered in ctDNA were*

关键词： Biliary tract cancer | ctDNA | NGS | concordance | high VAF

摘要： proteogenomic data to identify druggable* targets and forecast* | of 162 potentially targetable genes. Lastly, we | Abstract Background The utilization of PD1 and | CTLA4 inhibitors has revolutionized the treatment of | malignant melanoma (MM). However, resistance to targeted

关键词： malignant melanoma | skin cancer | ferroptosis | drug target prediction | HDAC | RTK inhibitor

摘要： similar to 50% protein-coding genes* through repression* | druggable aspects for promising future therapies for the | Diabetic neuropathy (DN) is one of the major | microvascular complications of diabetes mellitus affecting 50 | % of the diabetic population marred by various unmet

关键词： Diabetic complications | Neuropathy | MiRNAs | Chronic pain

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： analysis to systematically explore the druggable genes | druggable were considered desirable genes. We also | druggable genes with other cardiovascular diseases were | six druggable genes were associated with hemorrhagic | genes in hemorrhagic stroke; therefore, we used MR

关键词： Druggable genes | Hemorrhagic strokes | Mendelian randomization | Summary-data-based Mendelian randomization

摘要： druggable genes is of paramount importance for enhancing | cancer-druggable genes remains a critical challenge in | predict and evaluate cancer-druggable genes. MDMNI-DGD | discovering potentially druggable genes. Among more than | identified 872 potentially druggable genes. The findings

关键词： Druggable genes | Graph neural network | Multi-omics data | Multi-view network

摘要：, eight protein-coding genes were immune-related, such | as IRF3, CSK, and ACE, five among 16 druggable | genes were reported to interact with drugs, including | Background: Genome-wide association studies | (GWAS) have identified numerous variants associated

关键词： Psychiatric disorders | Plasma proteins | Proteome-wide association study | Mendelian randomization | Colocalization | Druggable genes

摘要： genes causally linked to neuroticism. To further | interactions between drugs and genes for drug prediction and | . Results: The analysis involved a total of 4473 druggable | genes, with two-sample Mendelian randomization (MR | ) identifying 186 genes that are causally linked to

关键词： Neuroticism | Mendelian randomization | Drug targets | Genetics

摘要： subtypes, we found 29 actionable druggable genes for | ) results, we identified 26 genes for overall breast | cancer, 25 genes for ER+ breast cancer and 4 genes | Luminal A breast cancer, 2 genes (IGF2 and TNNT3) for | HER2 negative breast cancer, and 3 genes (CASP8

关键词： Breast cancer | Drug repurposing | Molecular docking

摘要：In 1982, the RAS genes HRAS and KRAS were | discovered as the first human cancer genes, with KRAS later | in 2013 by Shokat and colleagues of a druggable | identified as one of the most frequently mutated oncogenes | . Yet, it took nearly 40 years to develop clinically

关键词： KRAS; colorectal carcinoma; drug resistance; non-small cell lung cancer; pancreatic ductal

摘要： expression of host genes in response to PheT gene silencing | , including genes involved in the cell cycle, apoptotic | its silencing may represent a druggable therapeutic | Mycobacterium abscessus (M. abscessus) is an | emerging pathogenic mycobacterium that mainly causes

关键词： Mycobacterium abscessus | AARS | PheT | Drug target | CRISPRi

摘要： or druggable targets in patients with advanced | to 118 genes for single- nucleotide variants (SNVs | ) and insertion or deletions (INDELs), 27 genes for | copy number alterations (CNAs), and 10 genes for | baseline. The most common genes altered in ctDNA were

关键词： Biliary tract cancer | ctDNA | NGS | concordance | high VAF

摘要： proteogenomic data to identify druggable targets and forecast | of 162 potentially targetable genes. Lastly, we | Abstract Background The utilization of PD1 and | CTLA4 inhibitors has revolutionized the treatment of | malignant melanoma (MM). However, resistance to targeted

关键词： malignant melanoma | skin cancer | ferroptosis | drug target prediction | HDAC | RTK inhibitor

摘要： similar to 50% protein-coding genes through repression | druggable aspects for promising future therapies for the | Diabetic neuropathy (DN) is one of the major | microvascular complications of diabetes mellitus affecting 50 | % of the diabetic population marred by various unmet

关键词： Diabetic complications | Neuropathy | MiRNAs | Chronic pain

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： analysis to systematically explore the druggable genes | druggable were considered desirable genes. We also | druggable genes with other cardiovascular diseases were | six druggable* genes were associated with hemorrhagic* | genes in hemorrhagic stroke; therefore, we used MR

摘要：, eight protein-coding genes* were immune-related, such* | as IRF3, CSK, and ACE, five among 16 druggable | genes were reported to interact with drugs, including | Background: Genome-wide association studies | (GWAS) have identified numerous variants associated

摘要： genes causally linked to neuroticism. To further | interactions between drugs and genes* for drug prediction and* | . Results: The analysis involved a total of 4473 druggable | genes, with two-sample Mendelian randomization (MR | ) identifying 186 genes* that are causally linked to*

摘要： subtypes, we found 29 actionable druggable* genes for* | ) results, we identified 26 genes* for overall breast* | cancer, 25 genes for ER+ breast cancer and 4 genes | Luminal A breast cancer, 2 genes* (IGF2 and TNNT3) for* | HER2 negative breast cancer, and 3 genes* (CASP8*

摘要：In 1982, the RAS genes* HRAS and KRAS were* | discovered as the first human cancer genes, with KRAS later | in 2013 by Shokat and colleagues of a druggable | identified as one of the most frequently mutated oncogenes | . Yet, it took nearly 40 years to develop clinically

摘要： expression of host genes* in response to PheT gene silencing* | , including genes* involved in the cell cycle, apoptotic* | its silencing may represent a druggable* therapeutic* | Mycobacterium abscessus (M. abscessus) is an | emerging pathogenic mycobacterium that mainly causes

摘要： or druggable* targets in patients with advanced* | to 118 genes* for single- nucleotide variants (SNVs* | ) and insertion or deletions (INDELs), 27 genes* for* | copy number alterations (CNAs), and 10 genes* for* | baseline. The most common genes* altered in ctDNA were*

摘要： proteogenomic data to identify druggable* targets and forecast* | of 162 potentially targetable genes. Lastly, we | Abstract Background The utilization of PD1 and | CTLA4 inhibitors has revolutionized the treatment of | malignant melanoma (MM). However, resistance to targeted

摘要： similar to 50% protein-coding genes* through repression* | druggable aspects for promising future therapies for the | Diabetic neuropathy (DN) is one of the major | microvascular complications of diabetes mellitus affecting 50 | % of the diabetic population marred by various unmet