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1. Doxorubicin or Epirubicin Versus Liposomal Doxorubicin Therapy-Differences in Cardiotoxicity NSTL国家科技图书文献中心

Buchalska, Barbara | Kaminska, Katarzyna ... - 《Cardiovascular toxicology.》 - 2025,25(2) - 248～268 - 共21页

摘要：Doxorubicin (DOX) is an important drug used in | the treatment of many malignancies. Unfortunately | DOX causes various side effects, with cardiotoxicity | being the most characteristic. Risk factors for DOX | induced cardiotoxicity (DIC) include cumulative dose of

关键词： Cancer treatment | Cardiotoxicity | Doxorubicin | Doxorubicin liposomal

2. PBPK model of pegylated liposomal doxorubicin to simultaneously predict the concentration-time profile of encapsulated and free doxorubicin in tissues NSTL国家科技图书文献中心

Cao, Xuewei | Li, Kejun ... - 《Drug delivery and translational research》 - 2025,15(4) - 1342～1362 - 共21页

摘要： doxorubicin in plasma and tissues in mice after intravenous | doxorubicin disposition components. The free doxorubicin | of free doxorubicin* produced by mononuclear* | doxorubicin liposomes and doxorubicin solution were | The objective of this study was to develop a

关键词： PBPK model | Doxorubicin | Liposome | Distribution | Pharmacokinetics

3. Managing Doxorubicin Cardiotoxicity: Insights Into Molecular Mechanisms and Protective Strategies NSTL国家科技图书文献中心

Al Khafaji, Adnan Ta... | Barakat, Ali Mohamme...... - 《Journal of biochemical and molecular toxicology》 - 2025,39(2) - e70155～e70155 - 共22页

摘要： anthracyclines, which include doxorubicin, daunorubicin, and | epirubicin. Doxorubicin* is particularly notable for its* | cardiac effects of doxorubicin* can manifest in several* | doxorubicin-induced cardiotoxicity. Key factors include the | knowledge regarding doxorubicin-induced cardiomyopathy. We

关键词： cardiotoxicity | chemotherapy | Doxorubicin | oxidative stress

4. STK32C modulates doxorubicin resistance in triple-negative breast cancer cells via glycolysis regulation NSTL国家科技图书文献中心

Xiao, Huawei | Liu, Lei ... - 《Molecular and Cellular Biochemistry》 - 2025,480(1) - 459～471 - 共13页

摘要： doxorubicin resistance in triple-negative breast cancer | little-explored kinase, to impact doxorubicin | unfavorable prognosis in doxorubicin-treated TNBC patients | significantly augmented the sensitivity of doxorubicin | -resistant TNBC cells to doxorubicin. Mechanistically, we

关键词： Triple-negative breast cancer | Doxorubicin resistance | Doxorubicin sensitivity | Glycolysis

5. 2-[18F]Fluoropropionic Acid PET Imaging of Doxorubicin-Induced Cardiotoxicity NSTL国家科技图书文献中心

Juan A.,Azcona | Anja S.,Wacker ... - 《Molecular imaging and biology》 - 2025,27(1) - 109～119 - 共11页

摘要： cancers with doxorubicin* is a common and predictable* | induced in mice by an 8-dose regimen of doxorubicin | effects of doxorubicin* exposure were assessed by* | observed in doxorubicin-treated animals. This uptake | doxorubicin-induced cardiomyopathy by PET.

关键词： Doxorubicin | Cardiotoxicity | Positron emission tomography | Short-chain fatty acid | Fatty acids | Metabolism | 2-[18F]Fluoropropionic acid | Monocarboxylate transporter | AZD3965

6. Ferroptosis: Latest evidence and perspectives on plant-derived natural active compounds mitigating doxorubicin-induced cardiotoxicity NSTL国家科技图书文献中心

Wang, Boyu | Wang, Jiameng ... - 《Journal of applied toxicology》 - 2025,45(1/2) - 135～158 - 共24页

摘要：Doxorubicin (DOX) is a chemotherapy drug | induces, including doxorubicin-induced cardiomyopathy | doxorubicin-induced cardiomyopathy (DIC) and summarizes how | limited by cardiotoxicity such as doxorubicin-induced | widely used in clinical settings, acting as a first

关键词： doxorubicin-induced cardiotoxicity | ferroptosis | iron metabolism | natural plant products | reactive oxygen species | doxorubicin‐induced cardiotoxicity

7. MALSU1-mediated regulation of mitochondrial function governs proliferation and doxorubicin resistance in triple-negative breast cancer cells NSTL国家科技图书文献中心

Zhuang, Feifei | Huang, Shaoyan ... - 《Molecular and Cellular Biochemistry》 - 2025,480(2) - 1197～1207 - 共11页

摘要： doxorubicin, a widely used chemotherapeutic agent, shows | and its impact on cell proliferation and doxorubicin | knockdown enhanced the sensitivity of doxorubicin | -resistant TNBC cells to doxorubicin* treatment. Furthermore* | of MALSU1 in TNBC biology and doxorubicin

关键词： Triple-negative breast cancer | Doxorubicin resistance | Doxorubicin sensitivity | Mitochondrial respiration

8. APX2009 sensitizes hypoxic breast cancer cells to doxorubicin by increasing its accumulation and caspase-3/7-mediated apoptosis NSTL国家科技图书文献中心

de Amorim, isis Salv... | Pinheiro, Daphne ... - 《Breast cancer research and treatment.》 - 2025,209(3) - 533～540 - 共8页

摘要： with doxorubicin* in hypoxia still needs to be* | sensitization of breast cancer cells to doxorubicin* in* | evaluate cell viability after APX2009 and doxorubicin | APE1 inhibition signature and doxorubicin* sensitivity* | APX2009 and doxorubicin* in hypoxia further decreased the*

关键词： APE1 | Doxorubicin | Hypoxia | Breast cancer | Apoptosis

9. Clinical significance of coadministration of moderate to strong CYP enzyme inhibitors with doxorubicin in breast cancer patients receiving AC chemotherapy NSTL国家科技图书文献中心

Dawson, Amy Priest | Frick, Chrissy D.... - 《Journal of oncology pharmacy practice》 - 2025,31(1) - 58～64 - 共7页

摘要：. Medication databases classify doxorubicin* coadministration* | incidence of toxicity secondary to doxorubicin* given with* | patients receiving doxorubicin* and* | cancer patients treated with doxorubicin* and* | outcomes included incidence of doxorubicin-associated

关键词： Doxorubicin | drug-drug interaction | cytochrome P450 inhibitors

10. Autophagy inhibition alleviates tumor desmoplasia and improves the efficacy of locally and systemically administered liposomal doxorubicin NSTL国家科技图书文献中心

Sandha, Kamalpreet K... | Kaur, Sukhleen ... - 《Journal of Controlled Release》 - 2025,378 - 1030～1044 - 共15页

摘要：) administered liposomal doxorubicin* was evaluated. In the in* | liposomal doxorubicin. The anticancer efficacy studies | of the i.v. and i.t. injected liposomal doxorubicin | The abnormal physiology of the tumor | microenvironment poses a challenge to the drug delivery in the

摘要：Doxorubicin (DOX) is an important drug used in | the treatment of many malignancies. Unfortunately | DOX causes various side effects, with cardiotoxicity | being the most characteristic. Risk factors for DOX | induced cardiotoxicity (DIC) include cumulative dose of

关键词： Cancer treatment | Cardiotoxicity | Doxorubicin | Doxorubicin liposomal

摘要： doxorubicin in plasma and tissues in mice after intravenous | doxorubicin disposition components. The free doxorubicin | of free doxorubicin* produced by mononuclear* | doxorubicin liposomes and doxorubicin solution were | The objective of this study was to develop a

关键词： PBPK model | Doxorubicin | Liposome | Distribution | Pharmacokinetics

关键词： cardiotoxicity | chemotherapy | Doxorubicin | oxidative stress

摘要： doxorubicin resistance in triple-negative breast cancer | little-explored kinase, to impact doxorubicin | unfavorable prognosis in doxorubicin-treated TNBC patients | significantly augmented the sensitivity of doxorubicin | -resistant TNBC cells to doxorubicin. Mechanistically, we

关键词： Triple-negative breast cancer | Doxorubicin resistance | Doxorubicin sensitivity | Glycolysis

摘要： cancers with doxorubicin* is a common and predictable* | induced in mice by an 8-dose regimen of doxorubicin | effects of doxorubicin* exposure were assessed by* | observed in doxorubicin-treated animals. This uptake | doxorubicin-induced cardiomyopathy by PET.

关键词： Doxorubicin | Cardiotoxicity | Positron emission tomography | Short-chain fatty acid | Fatty acids | Metabolism | 2-[18F]Fluoropropionic acid | Monocarboxylate transporter | AZD3965

摘要：Doxorubicin (DOX) is a chemotherapy drug | induces, including doxorubicin-induced cardiomyopathy | doxorubicin-induced cardiomyopathy (DIC) and summarizes how | limited by cardiotoxicity such as doxorubicin-induced | widely used in clinical settings, acting as a first

关键词： doxorubicin-induced cardiotoxicity | ferroptosis | iron metabolism | natural plant products | reactive oxygen species | doxorubicin‐induced cardiotoxicity

摘要： doxorubicin, a widely used chemotherapeutic agent, shows | and its impact on cell proliferation and doxorubicin | knockdown enhanced the sensitivity of doxorubicin | -resistant TNBC cells to doxorubicin* treatment. Furthermore* | of MALSU1 in TNBC biology and doxorubicin

关键词： Triple-negative breast cancer | Doxorubicin resistance | Doxorubicin sensitivity | Mitochondrial respiration

摘要： with doxorubicin* in hypoxia still needs to be* | sensitization of breast cancer cells to doxorubicin* in* | evaluate cell viability after APX2009 and doxorubicin | APE1 inhibition signature and doxorubicin* sensitivity* | APX2009 and doxorubicin* in hypoxia further decreased the*

关键词： APE1 | Doxorubicin | Hypoxia | Breast cancer | Apoptosis

摘要：. Medication databases classify doxorubicin* coadministration* | incidence of toxicity secondary to doxorubicin* given with* | patients receiving doxorubicin* and* | cancer patients treated with doxorubicin* and* | outcomes included incidence of doxorubicin-associated

关键词： Doxorubicin | drug-drug interaction | cytochrome P450 inhibitors

摘要：) administered liposomal doxorubicin* was evaluated. In the in* | liposomal doxorubicin. The anticancer efficacy studies | of the i.v. and i.t. injected liposomal doxorubicin | The abnormal physiology of the tumor | microenvironment poses a challenge to the drug delivery in the

关键词： Tumor microenvironment | Extracellular matrix | Autophagy | Collagen | Liposomal doxorubicin | Injectable hydrogel

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：Doxorubicin (DOX) is an important drug used in | the treatment of many malignancies. Unfortunately | DOX causes various side effects, with cardiotoxicity | being the most characteristic. Risk factors for DOX | induced cardiotoxicity (DIC) include cumulative dose of

关键词： Cancer treatment | Cardiotoxicity | Doxorubicin | Doxorubicin liposomal

摘要： doxorubicin in plasma and tissues in mice after intravenous | doxorubicin disposition components. The free doxorubicin | of free doxorubicin produced by mononuclear | doxorubicin liposomes and doxorubicin solution were | The objective of this study was to develop a

关键词： PBPK model | Doxorubicin | Liposome | Distribution | Pharmacokinetics

关键词： cardiotoxicity | chemotherapy | Doxorubicin | oxidative stress

摘要： doxorubicin resistance in triple-negative breast cancer | little-explored kinase, to impact doxorubicin | unfavorable prognosis in doxorubicin-treated TNBC patients | significantly augmented the sensitivity of doxorubicin | -resistant TNBC cells to doxorubicin. Mechanistically, we

关键词： Triple-negative breast cancer | Doxorubicin resistance | Doxorubicin sensitivity | Glycolysis

摘要： cancers with doxorubicin is a common and predictable | induced in mice by an 8-dose regimen of doxorubicin | effects of doxorubicin exposure were assessed by | observed in doxorubicin-treated animals. This uptake | doxorubicin-induced cardiomyopathy by PET.

关键词： Doxorubicin | Cardiotoxicity | Positron emission tomography | Short-chain fatty acid | Fatty acids | Metabolism | 2-[18F]Fluoropropionic acid | Monocarboxylate transporter | AZD3965

摘要：Doxorubicin (DOX) is a chemotherapy drug | induces, including doxorubicin-induced cardiomyopathy | doxorubicin-induced cardiomyopathy (DIC) and summarizes how | limited by cardiotoxicity such as doxorubicin-induced | widely used in clinical settings, acting as a first

关键词： doxorubicin-induced cardiotoxicity | ferroptosis | iron metabolism | natural plant products | reactive oxygen species | doxorubicin‐induced cardiotoxicity

摘要： doxorubicin, a widely used chemotherapeutic agent, shows | and its impact on cell proliferation and doxorubicin | knockdown enhanced the sensitivity of doxorubicin | -resistant TNBC cells to doxorubicin treatment. Furthermore | of MALSU1 in TNBC biology and doxorubicin

关键词： Triple-negative breast cancer | Doxorubicin resistance | Doxorubicin sensitivity | Mitochondrial respiration

摘要： with doxorubicin in hypoxia still needs to be | sensitization of breast cancer cells to doxorubicin in | evaluate cell viability after APX2009 and doxorubicin | APE1 inhibition signature and doxorubicin sensitivity | APX2009 and doxorubicin in hypoxia further decreased the

关键词： APE1 | Doxorubicin | Hypoxia | Breast cancer | Apoptosis

摘要：. Medication databases classify doxorubicin coadministration | incidence of toxicity secondary to doxorubicin given with | patients receiving doxorubicin and | cancer patients treated with doxorubicin and | outcomes included incidence of doxorubicin-associated

关键词： Doxorubicin | drug-drug interaction | cytochrome P450 inhibitors

摘要：) administered liposomal doxorubicin was evaluated. In the in | liposomal doxorubicin. The anticancer efficacy studies | of the i.v. and i.t. injected liposomal doxorubicin | The abnormal physiology of the tumor | microenvironment poses a challenge to the drug delivery in the

关键词： Tumor microenvironment | Extracellular matrix | Autophagy | Collagen | Liposomal doxorubicin | Injectable hydrogel

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： doxorubicin in plasma and tissues in mice after intravenous | doxorubicin disposition components. The free doxorubicin | of free doxorubicin* produced by mononuclear* | doxorubicin liposomes and doxorubicin solution were | The objective of this study was to develop a

摘要： cancers with doxorubicin* is a common and predictable* | induced in mice by an 8-dose regimen of doxorubicin | effects of doxorubicin* exposure were assessed by* | observed in doxorubicin-treated animals. This uptake | doxorubicin-induced cardiomyopathy by PET.

摘要： doxorubicin, a widely used chemotherapeutic agent, shows | and its impact on cell proliferation and doxorubicin | knockdown enhanced the sensitivity of doxorubicin | -resistant TNBC cells to doxorubicin* treatment. Furthermore* | of MALSU1 in TNBC biology and doxorubicin

摘要： with doxorubicin* in hypoxia still needs to be* | sensitization of breast cancer cells to doxorubicin* in* | evaluate cell viability after APX2009 and doxorubicin | APE1 inhibition signature and doxorubicin* sensitivity* | APX2009 and doxorubicin* in hypoxia further decreased the*

摘要：. Medication databases classify doxorubicin* coadministration* | incidence of toxicity secondary to doxorubicin* given with* | patients receiving doxorubicin* and* | cancer patients treated with doxorubicin* and* | outcomes included incidence of doxorubicin-associated

摘要：) administered liposomal doxorubicin* was evaluated. In the in* | liposomal doxorubicin. The anticancer efficacy studies | of the i.v. and i.t. injected liposomal doxorubicin | The abnormal physiology of the tumor | microenvironment poses a challenge to the drug delivery in the