NSTL国家科技图书文献中心

1. Synthesis of novel benzofuran-4,7-quinones from 4,6-dimethoxybenzofurans specifically targeting breast and lung cancer cells NSTL国家科技图书文献中心

Ucar, Tugce N. Uslu | Izgi, Samet ... - 《Monatshefte fur Chemie》 - 2025,156(4) - 467～480 - 共14页

摘要：4,6-Dimethoxy-2-phenylbenzofurans were | synthesized from the one-pot reactions of 3,5 | -dimethoxyphenol and a range of alpha-bromoacetophenones. The | dimethoxybenzofurans were then selectively formylated at C7 using | Vilsmeier-Haack method to generate 4,6-dimethoxybenzofuran

关键词： Heterocycles | Benzofuran | Cytotoxicity | Bioorganic chemistry | Dakin oxidation

2. Synthesis of Substituted Acyclic and Cyclic N -Alkylhydrazines by Enzymatic Reductive Hydrazinations NSTL国家科技图书文献中心

Borlinghaus, Niels | Calabrese, Donato ... - 《Chembiochem》 - 2025,26(4) - n/a～n/a - 共5页

摘要：Imine reductases (IREDs) provide promising | opportunities for the synthesis of various chiral amines | . Initially, asymmetric imine reduction was reported | , followed by reductive aminations of aldehydes and ketones | via imines. Herein we present the reductive

关键词： Biocatalysis | Bioorganic chemistry | Cofactor regeneration | Hydrazines | N -Heterocycles | N-Heterocycles

3. A Universal Support for the Solid-Phase Synthesis of Peptidyl-tRNA Mimics NSTL国家科技图书文献中心

Thaler, Julia | Mitteregger, Christo...... - 《Chembiochem》 - 2025,26(1) - n/a～n/a - 共5页

摘要：Hydrolysis-resistant RNA-peptide conjugates | that mimic peptidyl-tRNAs are often required for | structural and functional studies of protein synthesis at | the ribosome. These conjugates can be synthesized by | solid-phase chemical synthesis, which allows maximum

关键词： RNA peptide conjugates | Nucleosides | Bioorganic chemistry | Solid-phase synthesis | Photocleavable solid support

4. Trimethyl Lock Based Tools for Drug Delivery and Cell Imaging – Synthesis and Properties NSTL国家科技图书文献中心

Andrzej S. Skwarecki | Joanna Stefaniak‐Sko...... - 《Chemistry》 - 2025,31(4) - n/a～n/a - 共28页

摘要： bioorganic chemistry, particularly for their roles in the | Abstract Trimethyl lock (TML) systems have | become increasingly important in medicinal and | targeted delivery of therapeutic agents and as integral | components in fluorogenic probes for cellular imaging. The

关键词： Trimethyl lock | Antifungal | Anticancer | Drug delivery | Fluorescent probe

5. Recent development in coumarin-based cyanide sensors NSTL国家科技图书文献中心

Eapen, Asha K. | Das, Dipankar ... - 《Journal of Molecular Structure》 - 2025,1337 - 共40页

摘要： recognition, bioorganic* chemistry, molecular imaging, and* | , materials chemistry, medical sciences, molecular | analytical chemistry* to cure diseases and protect the* | High toxicity and adverse impacts of Cyanide | (CN-) on living beings and the environment have

关键词： Cyanide | Coumarin | Chemosensors | Colorimetry | Fluorimetry

6. tRNA‐Derived Fragments in Age‐Related Diseases: A Systematic Review NSTL国家科技图书文献中心

Kamilla Bakowska‐Zyw... | Alicja Rzepczak ... - 《Wiley Interdisciplinary Reviews.RNA》 - 2025,16(2) - 共18页

摘要：ABSTRACT Aging is a progressive weakening of | numerous functions of organisms resulting in diminished | abilities to safeguard against environmental damage and | augment physiological harmony. It is not a disease in | itself; however, it is a main cause of debilitating and

关键词： age‐related diseases | aging | tDR | tRNA‐derived fragments

7. Green synthesis and two-step chromatographic separation of thiocanthal and thiocanthol: Two novel biologically active sulfur derivatives of oleocanthal and oleacein from extra virgin olive oil NSTL国家科技图书文献中心

Di Risola D. | Mattioli R.... - 《Food Chemistry》 - 2025,463(Jan.15 Pt.2) - 1.1～1.9 - 共9页

摘要： of organic chemistry. It is quite difficult to | © 2024Oleocanthal and oleacein are the two | major secoiridoids exclusively present in extra virgin | olive oil (EVOO). Both compounds exert important | pharmacological activities, including anti-inflammatory, anti

关键词： Bioorganic and computational chemistry | COX inhibitors | Extra-virgin olive oil | Green chemistry | Mass spectrometry | NMR | Oleocanthal and oleacein | Sulfur-containing bioactive compounds

8. Nature‐inspired Novel Quaternary Ammonium Compounds: Synthesis, Antibacterial and Antibiofilm Activity NSTL国家科技图书文献中心

Liubov Muzychka | Diana Hodyna ... - 《ChemMedChem》 - 2025,20(5) - n/a～n/a - 共5页

摘要：Abstract Inspired by marine compounds isolated | from sponges and the increased need for new effective | antimicrobials, novel quaternary ammonium compounds with long | alkyl chains (C8‐C12) were designed and synthesized | . Antibacterial and antibiofilm activity of new compounds was

关键词： Natural products | Quaternary ammonium salts | Alkylation | Biological activity | Antibiofilm

9. A New Green and Efficient Method for Pyranopyrazoles Synthesis in a Single Pot Using Multiple Components, In Silico Pharmacokinetics with Cytotoxic Assessments NSTL国家科技图书文献中心

Jha, N. N. | Thorat, B. R.... - 《Russian journal of bioorganic chemistry》 - 2025,51(1) - 298～307 - 共10页

摘要：Objective: A multi-component development | method that does not include a catalyst has been | developed for the environmentally friendly synthesis of | pyranopyrazole derivatives containing a thioether bond. Methods | : This method includes non-hazardous solvents and

关键词： green synthesis | ecofriendly solvent | pyranopyrazoles | antifungal | antibacterial

10. Synthesis, Characterization, and Exploring the Antibacterial and Antifungal Potential of 1,4-Dihydropyrimido[1,2 -a ]-benzimidazole Derivatives NSTL国家科技图书文献中心

Katariya, Dharmesh | Pancholi, Kailash ... - 《Russian journal of bioorganic chemistry》 - 2025,51(1) - 330～339 - 共10页

摘要：Objective: This study aims to synthesize and | evaluate the antimicrobial efficacy of a series of 1,4 | -dihydropyrimido[1,2-a]benzimidazole derivatives (IVa-IVo) as | potential therapeutic agents against antibiotic-resistant | bacteria and fungi. The increasing prevalence of drug

摘要：4,6-Dimethoxy-2-phenylbenzofurans were | synthesized from the one-pot reactions of 3,5 | -dimethoxyphenol and a range of alpha-bromoacetophenones. The | dimethoxybenzofurans were then selectively formylated at C7 using | Vilsmeier-Haack method to generate 4,6-dimethoxybenzofuran

关键词： Heterocycles | Benzofuran | Cytotoxicity | Bioorganic chemistry | Dakin oxidation

摘要：Imine reductases (IREDs) provide promising | opportunities for the synthesis of various chiral amines | . Initially, asymmetric imine reduction was reported | , followed by reductive aminations of aldehydes and ketones | via imines. Herein we present the reductive

关键词： Biocatalysis | Bioorganic chemistry | Cofactor regeneration | Hydrazines | N -Heterocycles | N-Heterocycles

摘要：Hydrolysis-resistant RNA-peptide conjugates | that mimic peptidyl-tRNAs are often required for | structural and functional studies of protein synthesis at | the ribosome. These conjugates can be synthesized by | solid-phase chemical synthesis, which allows maximum

关键词： RNA peptide conjugates | Nucleosides | Bioorganic chemistry | Solid-phase synthesis | Photocleavable solid support

摘要： bioorganic chemistry, particularly for their roles in the | Abstract Trimethyl lock (TML) systems have | become increasingly important in medicinal and | targeted delivery of therapeutic agents and as integral | components in fluorogenic probes for cellular imaging. The

关键词： Trimethyl lock | Antifungal | Anticancer | Drug delivery | Fluorescent probe

摘要： recognition, bioorganic* chemistry, molecular imaging, and* | , materials chemistry, medical sciences, molecular | analytical chemistry* to cure diseases and protect the* | High toxicity and adverse impacts of Cyanide | (CN-) on living beings and the environment have

关键词： Cyanide | Coumarin | Chemosensors | Colorimetry | Fluorimetry

摘要：ABSTRACT Aging is a progressive weakening of | numerous functions of organisms resulting in diminished | abilities to safeguard against environmental damage and | augment physiological harmony. It is not a disease in | itself; however, it is a main cause of debilitating and

关键词： age‐related diseases | aging | tDR | tRNA‐derived fragments

摘要： of organic chemistry. It is quite difficult to | © 2024Oleocanthal and oleacein are the two | major secoiridoids exclusively present in extra virgin | olive oil (EVOO). Both compounds exert important | pharmacological activities, including anti-inflammatory, anti

关键词： Bioorganic and computational chemistry | COX inhibitors | Extra-virgin olive oil | Green chemistry | Mass spectrometry | NMR | Oleocanthal and oleacein | Sulfur-containing bioactive compounds

摘要：Abstract Inspired by marine compounds isolated | from sponges and the increased need for new effective | antimicrobials, novel quaternary ammonium compounds with long | alkyl chains (C8‐C12) were designed and synthesized | . Antibacterial and antibiofilm activity of new compounds was

关键词： Natural products | Quaternary ammonium salts | Alkylation | Biological activity | Antibiofilm

摘要：Objective: A multi-component development | method that does not include a catalyst has been | developed for the environmentally friendly synthesis of | pyranopyrazole derivatives containing a thioether bond. Methods | : This method includes non-hazardous solvents and

关键词： green synthesis | ecofriendly solvent | pyranopyrazoles | antifungal | antibacterial

摘要：Objective: This study aims to synthesize and | evaluate the antimicrobial efficacy of a series of 1,4 | -dihydropyrimido[1,2-a]benzimidazole derivatives (IVa-IVo) as | potential therapeutic agents against antibiotic-resistant | bacteria and fungi. The increasing prevalence of drug

关键词： antibacterial agents | antifungal agents | synthesis | 1,4-dihydropyrimido[1,2-a]benzimidazole derivatives | MIC | spectroscopic techniques

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：4,6-Dimethoxy-2-phenylbenzofurans were | synthesized from the one-pot reactions of 3,5 | -dimethoxyphenol and a range of alpha-bromoacetophenones. The | dimethoxybenzofurans were then selectively formylated at C7 using | Vilsmeier-Haack method to generate 4,6-dimethoxybenzofuran

关键词： Heterocycles | Benzofuran | Cytotoxicity | Bioorganic chemistry | Dakin oxidation

摘要：Imine reductases (IREDs) provide promising | opportunities for the synthesis of various chiral amines | . Initially, asymmetric imine reduction was reported | , followed by reductive aminations of aldehydes and ketones | via imines. Herein we present the reductive

关键词： Biocatalysis | Bioorganic chemistry | Cofactor regeneration | Hydrazines | N -Heterocycles | N-Heterocycles

摘要：Hydrolysis-resistant RNA-peptide conjugates | that mimic peptidyl-tRNAs are often required for | structural and functional studies of protein synthesis at | the ribosome. These conjugates can be synthesized by | solid-phase chemical synthesis, which allows maximum

关键词： RNA peptide conjugates | Nucleosides | Bioorganic chemistry | Solid-phase synthesis | Photocleavable solid support

摘要： bioorganic chemistry, particularly for their roles in the | Abstract Trimethyl lock (TML) systems have | become increasingly important in medicinal and | targeted delivery of therapeutic agents and as integral | components in fluorogenic probes for cellular imaging. The

关键词： Trimethyl lock | Antifungal | Anticancer | Drug delivery | Fluorescent probe

摘要： recognition, bioorganic chemistry, molecular imaging, and | , materials chemistry, medical sciences, molecular | analytical chemistry to cure diseases and protect the | High toxicity and adverse impacts of Cyanide | (CN-) on living beings and the environment have

关键词： Cyanide | Coumarin | Chemosensors | Colorimetry | Fluorimetry

摘要：ABSTRACT Aging is a progressive weakening of | numerous functions of organisms resulting in diminished | abilities to safeguard against environmental damage and | augment physiological harmony. It is not a disease in | itself; however, it is a main cause of debilitating and

关键词： age‐related diseases | aging | tDR | tRNA‐derived fragments

摘要： of organic chemistry. It is quite difficult to | © 2024Oleocanthal and oleacein are the two | major secoiridoids exclusively present in extra virgin | olive oil (EVOO). Both compounds exert important | pharmacological activities, including anti-inflammatory, anti

关键词： Bioorganic and computational chemistry | COX inhibitors | Extra-virgin olive oil | Green chemistry | Mass spectrometry | NMR | Oleocanthal and oleacein | Sulfur-containing bioactive compounds

摘要：Abstract Inspired by marine compounds isolated | from sponges and the increased need for new effective | antimicrobials, novel quaternary ammonium compounds with long | alkyl chains (C8‐C12) were designed and synthesized | . Antibacterial and antibiofilm activity of new compounds was

关键词： Natural products | Quaternary ammonium salts | Alkylation | Biological activity | Antibiofilm

摘要：Objective: A multi-component development | method that does not include a catalyst has been | developed for the environmentally friendly synthesis of | pyranopyrazole derivatives containing a thioether bond. Methods | : This method includes non-hazardous solvents and

关键词： green synthesis | ecofriendly solvent | pyranopyrazoles | antifungal | antibacterial

摘要：Objective: This study aims to synthesize and | evaluate the antimicrobial efficacy of a series of 1,4 | -dihydropyrimido[1,2-a]benzimidazole derivatives (IVa-IVo) as | potential therapeutic agents against antibiotic-resistant | bacteria and fungi. The increasing prevalence of drug

关键词： antibacterial agents | antifungal agents | synthesis | 1,4-dihydropyrimido[1,2-a]benzimidazole derivatives | MIC | spectroscopic techniques

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： recognition, bioorganic* chemistry, molecular imaging, and* | , materials chemistry, medical sciences, molecular | analytical chemistry* to cure diseases and protect the* | High toxicity and adverse impacts of Cyanide | (CN-) on living beings and the environment have