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1. ONC201 exerts oncogenic effects beyond its mitochondria-disturbing role in neuroblastoma subsets NSTL国家科技图书文献中心

Jiang, Jyun-Hong |  Lin, Yu-Han... -  《Journal of molecular medicine》 - 2025,103(5) - 571~582 - 共12页

摘要: downregulating the tumor suppressor ATRX. While it fails to |  upregulation and ATRX downregulation, suggesting that ONC201 | Neuroblastoma (NB) is a formidable challenge |  in pediatric oncology due to its intricate |  molecular landscape, necessitating multifaceted
关键词: Neuroblastoma |  ONC201 |  Non- MYCN -amplified cell line |  LGR5 |  ATRX

2. Alternative driver pathways in peripheral nerve sheath tumors - including DICER1 and/or KRAS alterations NSTL国家科技图书文献中心

Chang, Hsin-Yi |  Saoud, Carla... -  《Journal of Pathology》 - 2025,265(3) - 372~384 - 共13页

摘要: diagnosed as MPNST with co-existing DICER1, ATRX chromatin |  remodeler (ATRX), and KRAS G12V/A alterations occurring in | DICER1-associated sarcoma is an emerging |  entity, defined by either somatic or germline dicer 1 | , ribonuclease III (DICER1) mutations and sharing
关键词: peripheral nerve sheath tumor |  KRAS |  DICER1 |  ATRX |  TP53 |  MPNST |  methylation

3. Alternative lengthening of telomere-based immortalization renders H3G34R-mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens NSTL国家科技图书文献中心

Anna Laemmerer |  Christian Lehmann... -  《Neuro-oncology》 - 2025,27(3) - 811~827 - 共17页

摘要: (ATRX; DHG-H3G34R_ATRX) suggesting a unique |  ATRX loss in ALT activation also became apparent in |  H3G34R+/ATRX- iPSCs, the ALT-phenotype was associated | -thalassemia/mental retardation syndrome X-linked protein |  options. DHG-H3G34R further harbor deactivation of alpha
关键词: ATRX |  DNA damage |  diffuse hemispheric glioma |  H3G34R |  PARP inhibitor

4. Management of patients with small pancreatic neuroendocrine tumors from a biomarker and surgical perspective NSTL国家科技图书文献中心

Anna Vera D Verschuu... |  Lin Chen... -  《Endocrine-related cancer》 - 2025,32(5) - e240305~e240305 - 共14页

摘要:-based markers, such as ATRX and DAXX alterations | Pancreatic neuroendocrine tumors (PanNETs | ) have an age-adjusted incidence of 1.5 per 100,000 |  people, with a notable rise in the incidence of small |  (≤2 cm) non-functional PanNETs (NF-PanNETs) in
关键词: ATRX; DAXX; alternative lengthening of telomeres; biomarkers; pancreatic neuroendocrine tumors.

5. Detection of Alternative Lengthening of Telomeres via Chromogenic In Situ Hybridization for the Prognostication of PanNETs and Other Neoplasms NSTL国家科技图书文献中心

Heaphya, Christopher... |  Patel, Simmi... -  《Modern pathology》 - 2025,38(3) - 100651~100651 - 共11页 - 被引量:1

摘要:Molecular studies have shown alternative |  lengthening to telomeres (ALT) to be an important prognostic |  biomarker of shorter relapse-free survival (RFS) for |  patients with pancreatic neuroendocrine tumors (PanNETs | ) and other neoplasms. However, the preferred method
关键词: ATRX |  DAXX |  endocrine tumor |  sarcoma

6. Should we worry about high-grade pancreatic neuroendocrine tumor progression and alkylating agents? NSTL国家科技图书文献中心

Hackeng, Wenzel M. |  Dreijerink, Koen M. ...... -  《Journal of Pathology》 - 2025,266(1) - 1~4 - 共4页

摘要:Predicting metachronous metastases in |  localized pancreatic neuroendocrine tumors (PanNETs) and |  improving survival of patients with advanced disease are |  some of the most important goals in PanNET research | . Both are addressed by a study published recently in
关键词: DAXX |  ATRX |  MEN1 |  MMR |  TP53 |  tumorigenesis |  Ki-67 |  grade |  TMB |  NET...

7. A cross-species transcriptomic analysis reveals a novel 2-dimensional classification system explaining the invasiveness heterogeneity of pancreatic neuroendocrine tumor NSTL国家科技图书文献中心

Xiafei Hong |  Xingwu Zhang... -  《Cancer letters》 - 2025,611 - 217131~217131 - 共13页

摘要:, including DAXX/ATRX, MEN1 mutations, and copy number | /ATRX as the 'second hit' and confounding factors for |  invasiveness. Finally, by combining the 2D system, DAXX/ATRX | Pancreatic neuroendocrine tumors (PanNETs | ), the second most common type of primary pancreatic
关键词: Cross-species analysis; Molecular classification; Pancreatic neuroendocrine tumor; Prognostic

8. ERBB2/ERBB3 -mutated S100/SOX10-positive uterine sarcoma: something new NSTL国家科技图书文献中心

Shi, Wangpan J. |  Fadare, Oluwole -  《Virchows Archiv》 - 2025,486(3) - 605~610 - 共6页

摘要: ERBB2/ERBB3, CDKN2A deletion, inactivating ATRX | : ERBB2 p.Val777Leu, ATRX p.F2113Sfs*, CDKN2A deep | A distinctive subset of uterine mesenchymal |  tumors display recurrent genetic fusions involving |  receptor tyrosine kinases, including NTRK, PDGFB, FGFR1
关键词: Uterine sarcoma |  Receptor tyrosine kinases |  ERBB2, ERBB3, S100, SOX10, HER2, S100/SOX10, ERBB2/ERBB3 |  S100/SOX10

9. KMT2C Polymorphism in Familial Hypospadias NSTL国家科技图书文献中心

Kumar, Sourabh |  Sharma, Jyoti... -  《Indian journal of pediatrics》 - 2025,92(5) - 538~540 - 共3页

摘要:, ATRX, and CHD7 implicated in sex differentiation were | Hypospadias, a common congenital anomaly of |  male genitalia, shows significant heritability and |  familial recurrence, particularly in consanguineous |  families. This study explored the role of KMT2C
关键词: Hypospadias |  Whole exome sequencing |  KMT2C |  Lysine methyltransferase 2C |  BAHD1 |  Genetic architecture

10. Temporal increase in Ki-67 index in patients with pancreatic neuroendocrine tumours NSTL国家科技图书文献中心

Bourdeleau, Pauline |  Pokossy-Epee, Johann...... -  《Endocrine-related cancer》 - 2025,32(3) - e240321~e240321 - 共10页

摘要: (MEN1, ATRX/DAXX and PDX1/ARX) in PanNETs. We | -0.82], P = 0.027). MEN1 and ATRX/DAXX expressions | Pancreatic neuroendocrine tumours (PanNETs | ) have intra-tumour heterogeneity, notably regarding |  the Ki-67 index, which is a major prognostic factor
关键词: pancreatic neuroendocrine tumours |  metastases |  intra-tumour heterogeneity |  evolution |  Ki-67 index
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