NSTL国家科技图书文献中心

1. Chronic toxoplasmosis induces depression-like behaviors and neuroinflammatory responses in mice NSTL国家科技图书文献中心

Shi, Wen-Qian | Bai, Shao-Yuan ... - 《Acta tropica.》 - 2025,264 - Article 107568～Article 107568 - 共8页

摘要： cytokines (TNF-alpha, IL-1 beta, IL-6, IDO) was | Test (OST), and Tail Immersion Test (TIT). The | Approximately one-third of the global | population is infected with Toxoplasma gondii, which can | lead to chronic infection and induce a persistent

关键词： Chronic toxoplasmosis | Behavioral change | depression-like behaviors | neuroinflammation

2. Melatonin alleviates necrotizing enterocolitis by reducing bile acid levels through the SIRT1/FXR signalling axis NSTL国家科技图书文献中心

Lai, Jiahao | Li, Fei ... - 《International immunopharmacology》 - 2024,128 - 111360～111360 - 共6页

摘要： (OST-alpha), by upregulating SIRT1 expression while | protein (IBABP), and organic solute transporter-alpha | Bile acids (BAs) have increasingly been | implicated in the onset and progression of necrotizing | enterocolitis (NEC); multiple findings have demonstrated their

关键词： Melatonin | Necrotizing enterocolitis | Bile acids | FARNESOID-X-RECEPTOR | ALPHA-OST-BETA | TRANSPORTER | FXR | EXPRESSION

3. Integration of UPLC-MS/MS-based metabolomics and desorption electrospray ionization-mass spectrometry imaging reveals that Shouhui Tongbian Capsule alleviates slow transit constipation by regulating bile acid metabolism NSTL国家科技图书文献中心

Zhang, Na | Gu, Dong ... - 《Journal of chromatography, B. Analytical technologies in the biomedical and life sciences》 - 2024,1247 - ARTN 124331～ - 共8页

摘要：), organic solute transporter alpha* (OST alpha) and organic | solute transporter beta (OST(3) in the ileum tissue of* | Slow transit constipation (STC) is a common | intestinal disorder. Some studies reported that Shouhui | Tongbian Capsule (SHTB) can effectively mitigate STC

关键词： UPLC-MS/MS | DESI-MSI | Bile acid metabolism | Slow transit constipation | Shouhui Tongbian Capsule | IRRITABLE-BOWEL-SYNDROME | ALPHA-OST-BETA | TRANSPORTER | CANCER | HOMEOSTASIS

4. Integrin-Linked Kinase in the Development of Gastric Tumors Induced by Helicobacter pylori : Regulation and Prevention Potential NSTL国家科技图书文献中心

Li, Boqing | He, Jing ... - 《Helicobacter》 - 2024,29(4) - ARTN e13109～ - 共11页

摘要： mice. OST-T315 also reduced the release of TNF-alpha | necrosis factor alpha* (TNF-alpha), interleukin-6 (IL-6* | ), interleukin-1beta (IL-1 beta), and nitric oxide (NO) levels | with the ILK inhibitor OST-T315 elevated the | , IL-6, IL-1 beta, and NO, as well as the progression

关键词： gastric tumorigenesis | Helicobacter pylori | Hippo pathway | integrin-linked kinase | prevention target | Yes-associated protein 1 | EXPRESSION | ILK | METASTASIS | YAP/TAZ

5. FXR-FGF19 signaling in the gut–liver axis is dysregulated in patients with cirrhosis and correlates with impaired intestinal defence NSTL国家科技图书文献中心

Benedikt,Simbrunner | Benedikt S.,Hofer ... - 《Hepatology international》 - 2024,18(3) - 929～942 - 共14页 - 被引量：1

摘要： alpha/beta; (CYP7A1) cholesterol 7 alpha-hydroxylase | zonula occludens-1, occludin, and alpha-5-defensin | partner; (OST-α/-β) organic solute transporter subunit | ; (CYP8B1) sterol 12-alpha-hydroxylase; (HVPG) hepatic | ) occluding; (DEFA5) alpha-5-defensin.

关键词： ACLD | Portal hypertension | FXR | FGF19 | Intestinal barrier | Gut–liver axis

6. Fluorescence-based methods for studying activity and drug-drug interactions of hepatic solute carrier and ATP binding cassette proteins involved in ADME-Tox NSTL国家科技图书文献中心

Ozvegy-Laczka, Csill... | Ungvari, Orsolya ... - 《Biochemical Pharmacology》 - 2023,209 - 115448～115448 - 共8页 - 被引量：5

摘要：In humans, approximately 70% of drugs are | eliminated through the liver. This process is governed by | the concerted action of membrane transporters and | metabolic enzymes. Transporters mediating hepatocellular | up -take of drugs belong to the SLC (Solute carrier

关键词： Fluorescent or fluorogenic probe | In vitro transporter assay | In vivo imaging | Near infrared dyes | Theranostics | Transporter -drug interaction screening | CANCER RESISTANCE PROTEIN | SALT EXPORT PUMP | ANION-TRANSPORTING POLYPEPTIDES | EQUILIBRATIVE NUCLEOSIDE TRANSPORTERS...

7. Advances in understanding the regulatory mechanism of organic solute transporter alpha-beta NSTL国家科技图书文献中心

Lu, Zhen-Ning | He, Hong-Wei ... - 《Life sciences》 - 2022,310 - 121109～121109 - 共8页 - 被引量：1

摘要：The organic solute transporter alpha-beta (OST | alpha-OST beta) is a heteromeric transporter localized | regulating OST* alpha-OST beta. Human OST alpha/beta and* | mouse Ost* alpha/beta promoters are endowed with* | of OST* alpha-OST beta, explain the rationale*

关键词： Organic solute transporter ? | Bile acid | Cholestasis | Malabsorption | Regulatory mechanism | Nuclear receptors | PREGNANE-X-RECEPTOR | CONSTITUTIVE ANDROSTANE RECEPTOR | BILE-ACID TRANSPORTER | NF-KAPPA-B...

8. Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway SCIE Web of Science核心 NSTL国家科技图书文献中心

Zha, Zhengqi | Liu, Yaoyao ... - 《International Journal of Biological Macromolecules: Structure, Function and Interactions》 - 2022,201 - 47～58 - 共12页 - 被引量：2

摘要： repeating units of -> 4) beta-D-glucuronic acid (GlcA) (1 | -> 4)-alpha-D-N-acetylglucosamine (GlcNAc) (1 ->, is | modification of human 3-O-sulfotransferase-1 (3-OST-1 | Heparosan, with a linear chain of disaccharide | a potential starting chemical for heparin

关键词： 2-Deacetyl-3-O-sulfo-heparosan | Human lung cancer A549 cell | FGFRs | MAPK/JNK pathway | Apoptosis | STRUCTURAL-CHARACTERIZATION | SULFATE | POLYSACCHARIDE | MYCELIA | CELLS

9. Role of Organic Solute Transporter Alpha/Beta in Hepatotoxic Bile Acid Transport and Drug Interactions SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Beaudoin, James J. | Bezencon, Jacqueline ... - 《Toxicological sciences: An official journal of the Society of Toxicology》 - 2020,176(1) - 34～45 - 共12页 - 被引量：7

摘要：Organic solute transporter (OST) alpha/beta* is* | of OST* alpha/beta in bile acid-mediated drug* | alpha/beta-overexpressing cells revealed that OST | -maximal inhibitory concentrations for OST alpha/beta | glycocholate. The potential role of OST* alpha/beta in*

关键词： B-CLEAR | DILI | hepatotoxicity | OST alpha/beta | targeted proteomics

10. From fatty hepatocytes to impaired bile flow: Matching model systems for liver biology and disease NSTL国家科技图书文献中心

Kunst, Roni F. | Niemeijer, Marije ... - 《Biochemical Pharmacology》 - 2020,180 - 114173～114173 - 共7页 - 被引量：3

摘要：A large variety of model systems are used | in hepatobiliary research. In this review, we aim | to provide an overview of established and emerging | models for specific research questions. We specifically | discuss the value and limitations of these models for

关键词： NAFLD | MAFLD | NASH | Cholestasis | Organoids | Animal models | PLURIPOTENT STEM-CELLS | IN-VITRO MODEL | ORGANIC SOLUTE TRANSPORTER | PRECISION-CUT LIVER...