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1. High potency 3-carboxy-2-methylbenzofuran pendrin inhibitors as novel diuretics NSTL国家科技图书文献中心

Master, Riya J. | Karmakar, Joy ... - 《European Journal of Medicinal Chemistry》 - 2025,283 - 117133～117133 - 共6页

摘要：Pendrin (SLC26A4) is an anion exchanger | expressed in epithelial cells of kidney and lung. Pendrin | inhibition is a potential treatment approach for edema | , hypertension and inflammatory lung diseases. We have | previously identified first-in-class pendrin inhibitors by

关键词： Benzofuran | Edema | Hypertension | Asthma | Cystic fibrosis | SLC26A4

2. Best Practice & Research clinical obstetrics & gynaecology NSTL国家科技图书文献中心

Swanson, Kate | Norton, Mary E. - 《Best practice & research:Clinical obstetrics & gynaecology》 - 2025,98 - 102574～102574 - 共10页

摘要：Screening for fetal genetic disorders is a | focus of prenatal care. Cell free DNA (cfDNA | ) screening for aneuploidies became available in 2011 | . Initially available only to high-risk individuals, this | test is now standard of care in many settings. cfDNA

关键词： Cell free DNA | Aneuploidy screening | Genetic screening | Prenatal screening

3. Kabuki patients with CHDs: outcomes after cardiac surgery NSTL国家科技图书文献中心

Lam, Regina W. | Haro, Victoria ... - 《Cardiology in the young.》 - 2025,35(4) - 722～725 - 共4页

摘要：Objective: This study aims to examine the | surgical outcome of Kabuki syndrome patients after | neonatal congenital heart surgery.Methods: This was a | single-centre retrospective study of Kabuki syndrome | patients undergoing neonatal congenital heart surgery

关键词： Kabuki syndrome | neonatal cardiac surgery | CHD

4. Genomic Differences between Spontaneous versus Indicated Extreme Preterm Birth NSTL国家科技图书文献中心

Ambalavanan, Namasiv... | Cotten, C. Michael ... - 《American Journal of Perinatology》 - 2025,42(2) - 231～237 - 共7页

摘要：Objective Extremely preterm infants are at | high risk of neonatal mortality and morbidity | . Extreme preterm birth (PTB) may result from spontaneous | preterm labor or preterm premature rupture of membranes | or may be indicated due to preeclampsia, eclampsia

关键词： prematurity | genomics | preeclampsia | preterm labor

5. Loss of TRPV4 decreases NFκB-mediated myometrial inflammation and prevents preterm labor NSTL国家科技图书文献中心

Ingles, Judith A. | Rodriguez, Zahidee ... - 《The FASEB Journal》 - 2025,39(4) - e70418～e70418 - 共16页

摘要：Inflammation is a key initiating event in both | spontaneous term and preterm labor. However, the link | between inflammation and the onset of labor remains | incompletely understood. We identified the transient receptor | potential vanilloid 4 (TRPV4) channel as a critical

关键词： contractility | parturition | preterm birth

6. Thrombopoietin Receptor Agonists for Thrombocytopenia in Pediatric Hematologic Malignancies NSTL国家科技图书文献中心

Marinoff, Amanda E. | Thrall, Allyson ... - 《Pediatric blood & cancer.》 - 2025,72(3) - e31528～e31528 - 共9页

摘要：Background Thrombopoietin receptor agonists | (TPO-RAs) have demonstrated efficacy in treating | clinically significant thrombocytopenia, including | chemotherapy-induced thrombocytopenia in adults. However | , data regarding their safety and efficacy in pediatric

关键词： adolescent | eltrombopag | hematologic malignancies | leukemia | pediatric | romiplostim | thrombopoietin receptor agonist | young adults

7. A Joint Conversation: People With Cystic Fibrosis' Perception of Healthcare Teams' Knowledge, Comfort, and Barriers in Discussing Substance Use NSTL国家科技图书文献中心

Vaziri, Sanaz | Mcgarry, Meghan E.... - 《Pediatric Pulmonology》 - 2025,60(3) - e71017～e71017 - 共8页

摘要：BackgroundSubstance use has increased among | people with CF (pwCF), yet communication about use | remains understudied between pwCF and their healthcare | providers. ObjectiveInvestigate pwCF's perceptions | regarding their healthcare team's discussions surrounding

关键词： cbd | cystic fibrosis | marijuana | substance use | vaping

8. Prevent Acute Chest Syndrome checklist (PACScheck): A quality improvement initiative to reduce acute chest syndrome NSTL国家科技图书文献中心

Morrone, Kerry | Strumph, Kaitlin ... - 《Pediatric blood & cancer.》 - 2025,72(1) - e31378～e31378 - 共9页

摘要：BackgroundAcute chest syndrome (ACS) is a life | -threatening complication of sickle cell disease (SCD). The | Prevent Acute Chest Syndrome checklist (PACScheck) was | created to drive appropriate ordering of opioids | , incentive spirometry (IS), intravenous fluids (IVF

关键词： Outcomes research | sickle cell disease | support care

9. What is Unspoken: The Discomfort Experienced by Pediatric Resident Physicians Delivering Racially Discordant Clinical Care NSTL国家科技图书文献中心

Darwiche, Sabrina M. | Kuo, Anda K.... - 《Journal of health care for the poor and underserved》 - 2025,36(1) - 192～208 - 共18页

摘要：A diverse physician workforce is imperative to | addressing health inequities, but few physicians identify | as Black or Hispanic. Therefore, this study used | the social construction- ism framework to explore | pediatric residents' perceptions of race in medical

关键词： Medical education | racial concordance | health equity | structural racism.

10. An Overview of Invasive Ductal Carcinoma (IDC) in Women's Breast Cancer NSTL国家科技图书文献中心

Gallas, Adriana E. | Morenikeji, Grace O.... - 《Current molecular medicine》 - 2025,25(4) - 361～371 - 共11页

摘要：Invasive ductal carcinoma (IDC) is the most | common type of breast cancer, primarily affecting women | in the United States and across the world. This | review summarizes key concepts related to IDC causes | , treatment approaches, and the identification of biological

摘要：Pendrin (SLC26A4) is an anion exchanger | expressed in epithelial cells of kidney and lung. Pendrin | inhibition is a potential treatment approach for edema | , hypertension and inflammatory lung diseases. We have | previously identified first-in-class pendrin inhibitors by

关键词： Benzofuran | Edema | Hypertension | Asthma | Cystic fibrosis | SLC26A4

摘要：Screening for fetal genetic disorders is a | focus of prenatal care. Cell free DNA (cfDNA | ) screening for aneuploidies became available in 2011 | . Initially available only to high-risk individuals, this | test is now standard of care in many settings. cfDNA

关键词： Cell free DNA | Aneuploidy screening | Genetic screening | Prenatal screening

摘要：Objective: This study aims to examine the | surgical outcome of Kabuki syndrome patients after | neonatal congenital heart surgery.Methods: This was a | single-centre retrospective study of Kabuki syndrome | patients undergoing neonatal congenital heart surgery

关键词： Kabuki syndrome | neonatal cardiac surgery | CHD

摘要：Objective Extremely preterm infants are at | high risk of neonatal mortality and morbidity | . Extreme preterm birth (PTB) may result from spontaneous | preterm labor or preterm premature rupture of membranes | or may be indicated due to preeclampsia, eclampsia

关键词： prematurity | genomics | preeclampsia | preterm labor

摘要：Inflammation is a key initiating event in both | spontaneous term and preterm labor. However, the link | between inflammation and the onset of labor remains | incompletely understood. We identified the transient receptor | potential vanilloid 4 (TRPV4) channel as a critical

关键词： contractility | parturition | preterm birth

摘要：Background Thrombopoietin receptor agonists | (TPO-RAs) have demonstrated efficacy in treating | clinically significant thrombocytopenia, including | chemotherapy-induced thrombocytopenia in adults. However | , data regarding their safety and efficacy in pediatric

关键词： adolescent | eltrombopag | hematologic malignancies | leukemia | pediatric | romiplostim | thrombopoietin receptor agonist | young adults

摘要：BackgroundSubstance use has increased among | people with CF (pwCF), yet communication about use | remains understudied between pwCF and their healthcare | providers. ObjectiveInvestigate pwCF's perceptions | regarding their healthcare team's discussions surrounding

关键词： cbd | cystic fibrosis | marijuana | substance use | vaping

摘要：BackgroundAcute chest syndrome (ACS) is a life | -threatening complication of sickle cell disease (SCD). The | Prevent Acute Chest Syndrome checklist (PACScheck) was | created to drive appropriate ordering of opioids | , incentive spirometry (IS), intravenous fluids (IVF

关键词： Outcomes research | sickle cell disease | support care

摘要：A diverse physician workforce is imperative to | addressing health inequities, but few physicians identify | as Black or Hispanic. Therefore, this study used | the social construction- ism framework to explore | pediatric residents' perceptions of race in medical

关键词： Medical education | racial concordance | health equity | structural racism.

摘要：Invasive ductal carcinoma (IDC) is the most | common type of breast cancer, primarily affecting women | in the United States and across the world. This | review summarizes key concepts related to IDC causes | , treatment approaches, and the identification of biological

关键词： Invasive ductal carcinoma | breast cancer | carcinomas | cancer treatments | IDC

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