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1. The CXCR6-CXCL16 axis mediates T cell control of polyomavirus infection in the kidney

Lauver, Matthew D. | Katz, Zoe E.... - 《plos pathogens》 - 2025,21(3) - 共20页

摘要：BK polyomavirus (PyV) establishes lifelong | asymptomatic infections in the reno-urinary system of most | humans. BKPyV-associated nephropathy is the leading | infectious cause of kidney allograft loss. Using mouse PyV | , a natural murine pathogen that also persists in

关键词： BK POLYOMAVIRUS | BONE-MARROW | RECEPTOR | CXCL16 | VIRUS | EXPRESSION | IL-12 | CXCR6 | INTERLEUKIN-12 | THERAPY

2. Diversification, loss, and virulence gains of the major effector AvrStb6 during continental spread of the wheat pathogen Zymoseptoria tritici

Sampaio, Ana Margari... | Tralamazza, Sabina M...... - 《plos pathogens》 - 2025,21(3) - 共23页

摘要：Interactions between plant pathogens and their | hosts are highly dynamic and mainly driven by pathogen | effectors and plant receptors. Host-pathogen co-evolution | can cause rapid diversification or loss of pathogen | genes encoding host-exposed proteins. The molecular

关键词： MYCOSPHAERELLA-GRAMINICOLA | PARTIAL RESISTANCE | BLAST RESISTANCE | GENOME | FUNGAL | AVIRULENCE | GENE | CULTIVARS | EVOLUTION | BLOTCH

3. Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions

Perez-Castro, Miguel... | Erana, Hasier ... - 《plos pathogens》 - 2025,21(1) - 共49页

摘要：Prion diseases, particularly sporadic cases | , pose a challenge due to their complex nature and | heterogeneity. The underlying mechanism of the spontaneous | conversion from PrPC to PrPSc, the hallmark of prion | diseases, remains elusive. To shed light on this process

关键词： BANK VOLES | PHYSICAL-PROPERTIES | PROTEIN | MOLECULES | SCRAPIE | STRAINS | CLASSIFICATION | TRANSMISSION | CONVERSION | MODELS

4. A Helicobacter pylori flagellar motor accessory is needed to maintain the barrier function of the outer membrane during flagellar rotation

Rosinke, Kyle | Tachiyama, Shoichi ... - 《plos pathogens》 - 2025,21(1) - 共27页

摘要：The Helicobacter pylori flagellar motor | contains several accessory structures that are not found | in the archetypal Escherichia coli and Salmonella | enterica motors. H. pylori hp0838 encodes a previously | uncharacterized lipoprotein and is in an operon with flgP, which

关键词： PHOSPHOLIPASE-A | ROTARY MOTOR | MOTILITY | COLONIZATION | MECHANISM | SYSTEM | GENE | IDENTIFICATION | VISUALIZATION | MUTATIONS

5. Widespread release of translational repression across Plasmodium's host-to-vector transmission event

Rios, Kelly T. | Mcgee, James P.... - 《plos pathogens》 - 2025,21(1) - 共38页

摘要：Malaria parasites must respond quickly to | environmental changes, including during their transmission | between mammalian and mosquito hosts. Therefore, female | gametocytes proactively produce and translationally repress | mRNAs that encode essential proteins that the zygote

关键词： ZYGOTIC GENOME ACTIVATION | SEXUAL DEVELOPMENT | MASS-SPECTROMETRY | MESSENGER-RNA | PROTEIN | MOSQUITO | FALCIPARUM | BERGHEI | YOELII | EXPRESSION

6. Dynamic interplay of autophagy and membrane repair during Mycobacterium tuberculosis Infection

Augenstreich, Jacque... | Phan, Anna T.... - 《plos pathogens》 - 2025,21(1) - 共31页 - 被引量：3

摘要：Autophagy plays a crucial role in the host | response to Mycobacterium tuberculosis (Mtb) infection | , yet the dynamics and regulation of autophagy | induction on Mtb-containing vacuoles (MCVs) remain only | partially understood. We employed time-lapse confocal

关键词： LC3-ASSOCIATED PHAGOCYTOSIS | PHAGOSOME | SECRETION | MATURATION | RESISTANCE | VIRULENCE | PROTEINS | SURVIVAL | DEFENSE | PATHWAY

7. Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes

Awuoche, Erick O. | Smallenberger, Gretc...... - 《plos pathogens》 - 2025,21(1) - 共33页

摘要：Tsetse flies (Glossina spp.) vector African | trypanosomes that cause devastating diseases in humans and | domestic animals. Within the Glossina genus, species in | the Palpalis subgroup exhibit greater resistance to | trypanosome infections compared to those in the Morsitans

关键词： MULTIPLE SEQUENCE ALIGNMENT | ANTIMICROBIAL PEPTIDE | AFRICAN TRYPANOSOMES | IMMUNE-RESPONSES | INFECTION-RATES | MIDGUT LECTIN | BRUCEI-BRUCEI | DIPTERA | PROTEIN | FLIES

8. Citrus tristeza virus p20 suppresses antiviral RNA silencing by co-opting autophagy-related protein 8 to mediate the autophagic degradation of SGS3

Zhang, Yongle | Yang, Zuokun ... - 《plos pathogens》 - 2025,21(2) - 共26页

摘要：Viruses exploit autophagy to degrade host | immune components for their successful infection | . However, how viral factors sequester the autophagic | substrates into autophagosomes remains largely unknown. In | this study, we showed that p20 protein, a viral

关键词： INFECTION | EXPRESSION | PATHOGEN | COMPLEX | GENES | INTERACT | IMMUNITY

9. Dynamics of tissue repair regulatory T cells and damage in acute Trypanosoma cruzi infection

Boccardo, Santiago | Rodriguez, Constanza ... - 《plos pathogens》 - 2025,21(1) - 共31页

摘要：Tissue-repair regulatory T cells (trTregs | ) comprise a specialized cell subset essential for tissue | homeostasis and repair. While well-studied in sterile injury | models, their role in infection-induced tissue damage | and antimicrobial immunity is less understood. We

关键词： DENDRITIC CELLS | SKELETAL-MUSCLE | INTERLEUKIN-33 | MICE | IMMUNITY | IL-33 | ALARMIN | INNATE | GAMMA | ACCUMULATION

10. N6-methyladenosine modification of the subgroup J avian leukosis viral RNAs attenuates host innate immunity via MDA5 signaling

Yu, Mengmeng | Zhang, Li ... - 《plos pathogens》 - 2025,21(4) - 共25页

摘要：Subgroup J avian leukosis virus (ALV-J), a | retrovirus, elicits immunosuppression and persistent | infections in chickens. Although it is widely acknowledged | that ALV-J can evade the host's innate immune | defenses, the mechanisms behind this immune evasion

关键词： N-6-METHYLADENOSINE MODIFICATION | SEQUENCE-ANALYSIS | SIV INFECTION | NUCLEAR-RNA | VIRUS | METHYLATION | INTERFERON | HIV-1 | CHINA | RECOGNITION

摘要：BK polyomavirus (PyV) establishes lifelong | asymptomatic infections in the reno-urinary system of most | humans. BKPyV-associated nephropathy is the leading | infectious cause of kidney allograft loss. Using mouse PyV | , a natural murine pathogen that also persists in

关键词： BK POLYOMAVIRUS | BONE-MARROW | RECEPTOR | CXCL16 | VIRUS | EXPRESSION | IL-12 | CXCR6 | INTERLEUKIN-12 | THERAPY

摘要：Interactions between plant pathogens and their | hosts are highly dynamic and mainly driven by pathogen | effectors and plant receptors. Host-pathogen co-evolution | can cause rapid diversification or loss of pathogen | genes encoding host-exposed proteins. The molecular

关键词： MYCOSPHAERELLA-GRAMINICOLA | PARTIAL RESISTANCE | BLAST RESISTANCE | GENOME | FUNGAL | AVIRULENCE | GENE | CULTIVARS | EVOLUTION | BLOTCH

摘要：Prion diseases, particularly sporadic cases | , pose a challenge due to their complex nature and | heterogeneity. The underlying mechanism of the spontaneous | conversion from PrPC to PrPSc, the hallmark of prion | diseases, remains elusive. To shed light on this process

关键词： BANK VOLES | PHYSICAL-PROPERTIES | PROTEIN | MOLECULES | SCRAPIE | STRAINS | CLASSIFICATION | TRANSMISSION | CONVERSION | MODELS

摘要：The Helicobacter pylori flagellar motor | contains several accessory structures that are not found | in the archetypal Escherichia coli and Salmonella | enterica motors. H. pylori hp0838 encodes a previously | uncharacterized lipoprotein and is in an operon with flgP, which

关键词： PHOSPHOLIPASE-A | ROTARY MOTOR | MOTILITY | COLONIZATION | MECHANISM | SYSTEM | GENE | IDENTIFICATION | VISUALIZATION | MUTATIONS

摘要：Malaria parasites must respond quickly to | environmental changes, including during their transmission | between mammalian and mosquito hosts. Therefore, female | gametocytes proactively produce and translationally repress | mRNAs that encode essential proteins that the zygote

关键词： ZYGOTIC GENOME ACTIVATION | SEXUAL DEVELOPMENT | MASS-SPECTROMETRY | MESSENGER-RNA | PROTEIN | MOSQUITO | FALCIPARUM | BERGHEI | YOELII | EXPRESSION

摘要：Autophagy plays a crucial role in the host | response to Mycobacterium tuberculosis (Mtb) infection | , yet the dynamics and regulation of autophagy | induction on Mtb-containing vacuoles (MCVs) remain only | partially understood. We employed time-lapse confocal

关键词： LC3-ASSOCIATED PHAGOCYTOSIS | PHAGOSOME | SECRETION | MATURATION | RESISTANCE | VIRULENCE | PROTEINS | SURVIVAL | DEFENSE | PATHWAY

摘要：Tsetse flies (Glossina spp.) vector African | trypanosomes that cause devastating diseases in humans and | domestic animals. Within the Glossina genus, species in | the Palpalis subgroup exhibit greater resistance to | trypanosome infections compared to those in the Morsitans

关键词： MULTIPLE SEQUENCE ALIGNMENT | ANTIMICROBIAL PEPTIDE | AFRICAN TRYPANOSOMES | IMMUNE-RESPONSES | INFECTION-RATES | MIDGUT LECTIN | BRUCEI-BRUCEI | DIPTERA | PROTEIN | FLIES

摘要：Viruses exploit autophagy to degrade host | immune components for their successful infection | . However, how viral factors sequester the autophagic | substrates into autophagosomes remains largely unknown. In | this study, we showed that p20 protein, a viral

关键词： INFECTION | EXPRESSION | PATHOGEN | COMPLEX | GENES | INTERACT | IMMUNITY

摘要：Tissue-repair regulatory T cells (trTregs | ) comprise a specialized cell subset essential for tissue | homeostasis and repair. While well-studied in sterile injury | models, their role in infection-induced tissue damage | and antimicrobial immunity is less understood. We

关键词： DENDRITIC CELLS | SKELETAL-MUSCLE | INTERLEUKIN-33 | MICE | IMMUNITY | IL-33 | ALARMIN | INNATE | GAMMA | ACCUMULATION

摘要：Subgroup J avian leukosis virus (ALV-J), a | retrovirus, elicits immunosuppression and persistent | infections in chickens. Although it is widely acknowledged | that ALV-J can evade the host's innate immune | defenses, the mechanisms behind this immune evasion

关键词： N-6-METHYLADENOSINE MODIFICATION | SEQUENCE-ANALYSIS | SIV INFECTION | NUCLEAR-RNA | VIRUS | METHYLATION | INTERFERON | HIV-1 | CHINA | RECOGNITION

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