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1. Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicentre, open-label, randomised trial with a 2 x 2 factorial design NSTL国家科技图书文献中心

Molina, Jean-Michel | Bercot, Beatrice ... - 《The Lancet infectious diseases》 - 2024,24(10) - 1093～1104 - 共12页

摘要：Background Increased rates of sexually | transmitted infections (STIs) are reported among men who | have sex with men (MSM) and new interventions are | needed. We aimed to assess whether post-exposure | prophylaxis (PEP) with doxycycline could reduce the

关键词： HIV PREEXPOSURE PROPHYLAXIS | NEISSERIA-GONORRHOEAE | RESISTANCE | MEN | SEX | DISEASE | RISK

2. Effectiveness and safety of modified fully oral 9-month treatment regimens for rifampicin-resistant tuberculosis: a prospective cohort study NSTL国家科技图书文献中心

Korotych, Oleksandr | Achar, Jay ... - 《The Lancet infectious diseases》 - 2024,24(10) - 1151～1161 - 共11页

摘要：Background In 2020, WHO guidelines prioritised | the use of a standard fully oral short treatment | regimen (STR) consisting of bedaquiline, levofloxacin or | moxifloxacin, ethionamide, ethambutol, high-dose isoniazid | , pyrazinamide, and clofazimine for the management of

关键词： TREATMENT OUTCOMES | LEVOFLOXACIN | MULTICENTER

3. Incidence and risk factors of tuberculosis among 420 854 household contacts of patients with tuberculosis in the 100 Million Brazilian Cohort (2004-18): a cohort study NSTL国家科技图书文献中心

Pinto, Priscila F. P... | Teixeira, Camila S. ...... - 《The Lancet infectious diseases》 - 2024,24(1) - 46～56 - 共11页

摘要：Background: Although household contacts of | patients with tuberculosis are known to be particularly | vulnerable to tuberculosis, the published evidence focused | on this group at high risk within the low-income | and middle-income country context remains sparse

关键词： TRANSMISSION | CHILDREN

4. Efficacy and immunogenicity following dengue virus-1 human challenge after a tetravalent prime-boost dengue vaccine regimen: an open-label, phase 1trial NSTL国家科技图书文献中心

Lyke, Kirsten E. | Chua, Joel, V ... - 《The Lancet infectious diseases》 - 2024,24(8) - 896～908 - 共13页

摘要：Background Dengue human infection models | (DHIMs) are important tools to down-select dengue | vaccine candidates and establish tetravalent efficacy | before advanced clinical field trials. We aimed to | provide data for the safety and immunogenicity of DHIM

关键词： ANTIBODY-DEPENDENT ENHANCEMENT | DISEASE | LIVE | CHILDREN

5. Carbapenem use in extended-spectrum cephalosporinresistant Enterobacterales infections in US hospitals and influence of IDSA guidance: a retrospective cohort study NSTL国家科技图书文献中心

Walker, Morgan K. | Diao, Guoqing ... - 《The Lancet infectious diseases》 - 2024,24(8) - 856～867 - 共12页

摘要：Background Disparate and rapidly changing | practice recommendations from major professional | infectious diseases societies for managing non-severe | infections caused by extended-spectrum beta-lactamase | -producing Enterobacterales might hamper carbapenem

关键词： BLOOD-STREAM INFECTIONS | LACTAMASE-PRODUCING-ENTEROBACTERIACEAE | PIPERACILLIN-TAZOBACTAM | IMPLEMENTATION | OUTCOMES | THERAPY

6. Managing treatment failure in Neisseria gonorrhoeae infection: current guidelines and future directions NSTL国家科技图书文献中心

Allan-Blitz, Lao-Tzu | Fifer, Helen ... - 《The Lancet infectious diseases》 - 2024,24(8) - e532～e538 - 共7页

摘要：Due to the continued emergence of resistance | to extended-spectrum cephalosporin antibiotics | , clinicians are increasingly more likely to encounter cases | of Neisseria gonorrhoeae treatment failure. The | current international treatment guidelines offer few

关键词： SEXUALLY-TRANSMITTED-DISEASES | PHARYNGEAL GONORRHEA | ANTIMICROBIAL RESISTANCE | OROPHARYNGEAL GONORRHEA | MULTIDRUG-RESISTANT | DRUG-RESISTANT | 500 MG | CEFTRIAXONE | CIPROFLOXACIN | THERAPY

7. Will two doses of pneumococcal conjugate vaccine be enough? NSTL国家科技图书文献中心

Russell, Fiona M. | Chokephaibulkit, Kul... - 《The Lancet infectious diseases》 - 2024,24(5) - 449～451 - 共3页

摘要：Pneumococcal conjugate vaccine (PCV) is one of | the most expensive vaccines in the paediatric | vaccination schedule. To reduce cost and the number of | injections, there has been major research investments to | identify whether a two-dose infant PCV schedule is non

关键词： NASOPHARYNGEAL CARRIAGE | POLYSACCHARIDE VACCINE

8. Quadrivalent dengue-virus vaccines: challenges and opportunities for India NSTL国家科技图书文献中心

Medigeshi, Guruprasa... | Islam, Farzana ... - 《The Lancet infectious diseases》 - 2024,24(5) - e270～e271 - 共2页

摘要：An estimated 12·9 million primary dengue-virus | infections occurred in India in 2017, according to the | constant force of infection model.1 Vaccine-efficacy | studies for quadrivalent dengue-virus vaccines conducted | in other endemic countries have provided an

关键词： EFFICACY | CHILDREN

9. Safety and immunogenicity of the intranasal H3N2 M2 -deficient single-replication influenza vaccine alone or coadministered with an inactivated influenza vaccine (Fluzone High-Dose Quadrivalent) in adults aged 65-85 years in the USA: a multicentre, randomised, double-blind double-dummy, phase 1b trial NSTL国家科技图书文献中心

Eiden, Joseph | Fierro, Carlos ... - 《The Lancet infectious diseases》 - 2024,24(10) - 1118～1129 - 共12页

摘要：Background Older adults (aged >= 65 years | ) show increased susceptibility to severe disease with | influenza virus infection, accounting for 70-85% of annual | influenza-related fatalities in the USA. Stimulating | mucosal antibodies and T cells might enhance the low

关键词： SEASONAL INFLUENZA | OLDER-ADULTS | VIRUS-VACCINES | LIVE | PROTECTION | EFFICACY | NEURAMINIDASE | RESPONSES | CORRELATE | ANTIBODY

10. Antimicrobial treatment imprecision: an outcome-based model to close the data-to-action loop NSTL国家科技图书文献中心

Howard, Alex | Reza, Nada ... - 《The Lancet infectious diseases》 - 2024,24(1) - e47～e58 - 共12页

摘要：Health-care systems, food supply chains, and | society in general are threatened by the inexorable rise | of antimicrobial resistance. This threat is driven | by many factors, one of which is inappropriate | antimicrobial treatment. The ability of policy makers and

摘要：Background Increased rates of sexually | transmitted infections (STIs) are reported among men who | have sex with men (MSM) and new interventions are | needed. We aimed to assess whether post-exposure | prophylaxis (PEP) with doxycycline could reduce the

关键词： HIV PREEXPOSURE PROPHYLAXIS | NEISSERIA-GONORRHOEAE | RESISTANCE | MEN | SEX | DISEASE | RISK

摘要：Background In 2020, WHO guidelines prioritised | the use of a standard fully oral short treatment | regimen (STR) consisting of bedaquiline, levofloxacin or | moxifloxacin, ethionamide, ethambutol, high-dose isoniazid | , pyrazinamide, and clofazimine for the management of

关键词： TREATMENT OUTCOMES | LEVOFLOXACIN | MULTICENTER

摘要：Background: Although household contacts of | patients with tuberculosis are known to be particularly | vulnerable to tuberculosis, the published evidence focused | on this group at high risk within the low-income | and middle-income country context remains sparse

关键词： TRANSMISSION | CHILDREN

摘要：Background Dengue human infection models | (DHIMs) are important tools to down-select dengue | vaccine candidates and establish tetravalent efficacy | before advanced clinical field trials. We aimed to | provide data for the safety and immunogenicity of DHIM

关键词： ANTIBODY-DEPENDENT ENHANCEMENT | DISEASE | LIVE | CHILDREN

摘要：Background Disparate and rapidly changing | practice recommendations from major professional | infectious diseases societies for managing non-severe | infections caused by extended-spectrum beta-lactamase | -producing Enterobacterales might hamper carbapenem

关键词： BLOOD-STREAM INFECTIONS | LACTAMASE-PRODUCING-ENTEROBACTERIACEAE | PIPERACILLIN-TAZOBACTAM | IMPLEMENTATION | OUTCOMES | THERAPY

摘要：Due to the continued emergence of resistance | to extended-spectrum cephalosporin antibiotics | , clinicians are increasingly more likely to encounter cases | of Neisseria gonorrhoeae treatment failure. The | current international treatment guidelines offer few

关键词： SEXUALLY-TRANSMITTED-DISEASES | PHARYNGEAL GONORRHEA | ANTIMICROBIAL RESISTANCE | OROPHARYNGEAL GONORRHEA | MULTIDRUG-RESISTANT | DRUG-RESISTANT | 500 MG | CEFTRIAXONE | CIPROFLOXACIN | THERAPY

摘要：Pneumococcal conjugate vaccine (PCV) is one of | the most expensive vaccines in the paediatric | vaccination schedule. To reduce cost and the number of | injections, there has been major research investments to | identify whether a two-dose infant PCV schedule is non

关键词： NASOPHARYNGEAL CARRIAGE | POLYSACCHARIDE VACCINE

摘要：An estimated 12·9 million primary dengue-virus | infections occurred in India in 2017, according to the | constant force of infection model.1 Vaccine-efficacy | studies for quadrivalent dengue-virus vaccines conducted | in other endemic countries have provided an

关键词： EFFICACY | CHILDREN

摘要：Background Older adults (aged >= 65 years | ) show increased susceptibility to severe disease with | influenza virus infection, accounting for 70-85% of annual | influenza-related fatalities in the USA. Stimulating | mucosal antibodies and T cells might enhance the low

关键词： SEASONAL INFLUENZA | OLDER-ADULTS | VIRUS-VACCINES | LIVE | PROTECTION | EFFICACY | NEURAMINIDASE | RESPONSES | CORRELATE | ANTIBODY

摘要：Health-care systems, food supply chains, and | society in general are threatened by the inexorable rise | of antimicrobial resistance. This threat is driven | by many factors, one of which is inappropriate | antimicrobial treatment. The ability of policy makers and

关键词： HEALTH-CARE | ANTIBIOTICS | THERAPY

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