NSTL国家科技图书文献中心

1. Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies NSTL国家科技图书文献中心

Rubin, David T. | Allegretti, Jessica ...... - 《The Lancet》 - 2025,405(10472) - 33～49 - 共17页

摘要：Background Interleukin-23 inhibition is | effective in treating ulcerative colitis. Guselkumab is a | dual-acting, human IgG1, interleukin-23p19 subunit | inhibitor that potently neutralises interleukin-23 and can | bind to CD64. We aimed to evaluate the efficacy and

关键词： Western University | London | diarrhoea | rectal bleeding | abdominal pain | bowel

2. Bayesian statistics for clinical research NSTL国家科技图书文献中心

Goligher, Ewan C. | Heath, Anna ... - 《The Lancet》 - 2024,404(10457) - 1067～1076 - 共10页

摘要：Frequentist and Bayesian statistics represent | two differing paradigms for the analysis of data | . Frequentism became the dominant mode of statistical thinking | in medical practice during the 20th century. The | advent of modern computing has made Bayesian analysis

关键词： CRITICAL-CARE | TRIALS | CONFIDENCE | DESIGN | PRIORS

3. Obesity in adults NSTL国家科技图书文献中心

Lingvay, Ildiko | Cohen, Ricardo, V ... - 《The Lancet》 - 2024,404(10456) - 972～987 - 共16页

摘要：Obesity has increased in prevalence worldwide | and WHO has declared it a global epidemic | . Population-level preventive interventions have been | insufficient to slow down this trajectory. Obesity is a | complex, heterogeneous, chronic, and progressive disease

关键词： LIFE-STYLE INTERVENTION | Y GASTRIC BYPASS | LAPAROSCOPIC SLEEVE GASTRECTOMY | SEMAGLUTIDE 2.4 MG | BODY-MASS INDEX | TERM-FOLLOW-UP | BARIATRIC SURGERY | WEIGHT-LOSS | METABOLIC SURGERY | MEDICAL THERAPY

4. Primary biliary cholangitis NSTL国家科技图书文献中心

Tanakai, Atsushi | Mai, Xiong ... - 《The Lancet》 - 2024,404(10457) - 1053～1066 - 共14页

摘要：Primary biliary cholangitis is a chronic | , autoimmune, cholestatic disease that mainly affects women | aged 40-70 years. Recent epidemiological studies have | shown an increasing incidence worldwide despite | geographical heterogeneity and a decrease in the female-to

关键词： QUALITY-OF-LIFE | PLACEBO-CONTROLLED TRIAL | RISK-FACTORS | HEPATOCELLULAR-CARCINOMA | ANTIMITOCHONDRIAL ANTIBODIES | CIRRHOSIS | OSTEOPOROSIS | BEZAFIBRATE | MANAGEMENT | CELLS

5. Repeat placental growth factor-based testing in women with suspected preterm pre-eclampsia (PARROT-2) : a multicentre, parallel-group, superiority, randomised controlled trial NSTL国家科技图书文献中心

Hurrell, Alice | Webster, Louise ... - 《The Lancet》 - 2024,403(10427) - 619～631 - 共13页

摘要：Background Placental growth factor (PlGF | )-based testing has high diagnostic accuracy for | predicting pre-eclampsia needing delivery, significantly | reducing time to diagnosis and severe maternal adverse | outcomes. The clinical benefit of repeat PlGF-based

关键词： OUTCOMES | RISK

6. Respiratory syncytial virus vaccination and immunoprophylaxis: realising the potential for protection of young children NSTL国家科技图书文献中心

Pecenka, Clint | Sparrow, Erin ... - 《The Lancet》 - 2024,404(10458) - 1157～1170 - 共14页

摘要：The search for safe and efficacious products | to prevent severe respiratory syncytial virus (RSV | ) disease in young infants has lasted more than 60 years | . In high-income and middle-income countries, two new | products have been authorised: an RSV monoclonal antibody

关键词： RSV | PREVENTION | NIRSEVIMAB | VACCINES | INFANTS | IMMUNIZATION | PRETERM | PROGRAM

7. Chronic urticaria: unmet needs, emerging drugs, and new perspectives on personalised treatment NSTL国家科技图书文献中心

Zuberbier, Torsten | Ensina, Luis Felipe ... - 《The Lancet》 - 2024,404(10450) - 393～404 - 共12页

摘要：Chronic urticaria is a common and debilitating | mast cell-driven skin disease presenting with itchy | wheals, angiooedema, or both. Chronic urticaria is | classified as spontaneous (without definite triggers) and | inducible (with definite and subtype-specific triggers; eg

关键词： DEMONSTRATES CLINICAL ACTIVITY | OMALIZUMAB TREATMENT | ALLERGIC-ASTHMA | IGE | CYCLOSPORINE | METAANALYSIS | EFFICACY | FEATURES | PATIENT | SAFETY

8. The global blood donation index: an imperfect measure of transfusion need NSTL国家科技图书文献中心

Jacobs, Jeremy W. | Bates, Imelda ... - 《The Lancet》 - 2024,404(10456) - 988～990 - 共3页

摘要：The optimum number of units of blood and the | associated number of blood donors required to meet a given | population's needs remain undetermined globally. Typically, a | whole blood donation rate of ten donations per 1000 | population, at a minimum, is necessary to meet a country's

关键词： SAMPLE

9. Genetic sequencing analysis of monkeypox virus clade I in Republic of the Congo: a cross-sectional, descriptive study NSTL国家科技图书文献中心

Yinda, Claude Kwe | Mayengue, Pembe Issa...... - 《The Lancet》 - 2024,404(10465) - 1815～1822 - 共8页

摘要：Background Monkeypox virus clade I is endemic | in several central African countries and | characterised by an increase in disease severity and mortality | . Since October, 2023, a large-scale mpox outbreak has | emerged in DR Congo, and in March, 2024, the first

关键词： MPOX | TRANSMISSION | ALIGNMENT

10. Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials NSTL国家科技图书文献中心

Gao, Ya | Guyatt, Gordon ... - 《The Lancet》 - 2024,404(10454) - 753～763 - 共11页

摘要：Background The optimal antiviral drug for | treatment of severe influenza remains unclear. To support | updated WHO influenza clinical guidelines, this | systematic review and network meta-analysis evaluated | antivirals for treatment of patients with severe influenza

关键词： NEURAMINIDASE INHIBITORS | INTRAVENOUS PERAMIVIR | OSELTAMIVIR TREATMENT | HOSPITALIZED-PATIENTS | SEASONAL INFLUENZA | ORAL OSELTAMIVIR | DOUBLE-BLIND | GRADE | CONSISTENCY | CERTAINTY