NSTL国家科技图书文献中心

1. Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function NSTL国家科技图书文献中心

Liu, Dan | Winer, Benjamin Y.... - 《Nature immunology》 - 2024,25(1) - 共30页 - 被引量：2

摘要：Spleen marginal zone (MZ) B cells are | important for antibody responses against blood-borne | antigens. The signals they use to detect exposure to | blood are not well defined. Here, using intravital two | -photon microscopy in mice, we observe transient

关键词： RECEPTOR CD97 | ADHESION | PROTEIN | MIGRATION | RHO | COMPLEMENT | LSC | LOCALIZATION | EXPRESSION | CD55

2. X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system NSTL国家科技图书文献中心

Lafleur, Martin W. | Lemmen, Ashlyn M.... - 《Nature immunology》 - 2024,25(1) - 共27页 - 被引量：3

摘要：Annotation of immunologic gene function in | vivo typically requires the generation of knockout | mice, which is time consuming and low throughput. We | previously developed CHimeric IMmune Editing (CHIME), a | CRISPR-Cas9 bone marrow delivery system for

关键词： PROTEIN-TYROSINE PHOSPHATASES | ONE-STEP GENERATION | T-CELLS | CRISPR | DELIVERY | DELETION | MUTAGENESIS | MUTATIONS | ALLELES | SCREENS

3. Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping NSTL国家科技图书文献中心

Netskar, Herman | Pfefferle, Aline ... - 《Nature immunology》 - 2024,25(8) - 共37页 - 被引量：11

摘要：The functional diversity of natural killer (NK | ) cell repertoires stems from differentiation | , homeostatic, receptor-ligand interactions and adaptive-like | responses to viral infections. In the present study, we | generated a single-cell transcriptional reference map of

关键词： HUMAN NK CELLS | EXPRESSION | PROLIFERATION | SIGNATURES | INTERACTS | KIR

4. Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells NSTL国家科技图书文献中心

Board, Nathan L. | Yuan, Zhe ... - 《Nature immunology》 - 2024,25(3) - 共27页 - 被引量：10

摘要：The persistence of CD4+ T cells carrying | latent human immunodeficiency virus-1 (HIV-1 | ) proviruses is the main barrier to a cure. New therapeutics | to enhance HIV-1-specific immune responses and | clear infected cells will probably be necessary to

关键词： HUMAN-IMMUNODEFICIENCY-VIRUS | T-CELLS | ANTIRETROVIRAL THERAPY | LATENT RESERVOIR | NK CELLS | IN-VIVO | PROVIRUSES | BROAD | REACTIVATION | REPLICATION

5. A mechanism for BCG vaccine cross-protection against pulmonary viral infections NSTL国家科技图书文献中心

Tran, Kim A. | Divangahi, Maziar - 《Nature immunology》 - 2024,25(3) - 403～404 - 共2页

摘要：Bacillus Calmette-Guerin (BCG) is the only | available vaccine against tuberculosis. As well as being | an effective vaccine against tuberculosis, BCG also | provides off-target protection against various pathogens | . Here, we report a mechanism for BCG-mediated cross

关键词： TUBERCULOSIS | CELLS

6. Alterations of iron homeostasis as a potential druggable driver of long COVID NSTL国家科技图书文献中心

Marques, Oriana | Muckenthaler, Martin... - 《Nature immunology》 - 2024,25(3) - 387～389 - 共3页

摘要：Drivers of persistent symptoms after acute | COVID-19 remain largely unknown. Alterations in immune | function, iron homeostasis and dysregulated | erythropoiesis are described as treatable correlates of post | -acute sequelae of COVID-19.

关键词： HYPOFERREMIA

7. Diversity of group 1 innate lymphoid cells in human tissues NSTL国家科技图书文献中心

Jaeger, Natalia | Antonova, Alina Ulez...... - 《Nature immunology》 - 2024,25(8) - 共31页 - 被引量：6

摘要：Group 1 innate lymphoid cells (ILC1s) are | cytotoxic and interferon gamma-producing lymphocytes | lacking antigen-specific receptors, which include ILC1s | and natural killer (NK) cells. In mice, ILC1s differ | from NK cells, as they develop independently of the

关键词： NATURAL-KILLER | NK CELLS | T-BET | HETEROGENEITY | RESIDENCY | INSTRUCT | PROGRAMS | IMMUNITY | SUBSET | LIVER

8. A second-generation M1-polarized CAR macrophage with antitumor efficacy NSTL国家科技图书文献中心

Lei, Anhua | Yu, Hua ... - 《Nature immunology》 - 2024,25(1) - 共45页 - 被引量：36

摘要：Chimeric antigen receptor (CAR) T cell | therapies have successfully treated hematological | malignancies. Macrophages have also gained attention as an | immunotherapy owing to their immunomodulatory capacity and | ability to infiltrate solid tumors and phagocytize tumor

关键词： TUMOR-ASSOCIATED MACROPHAGES | PLURIPOTENT STEM-CELLS | TOLL-LIKE RECEPTORS | DIFFERENTIATION | ENDOCYTOSIS

9. Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells NSTL国家科技图书文献中心

Hernandez-Lopez, Pat... | van Diest, Eline ... - 《Nature immunology》 - 2024,25(1) - 共30页 - 被引量：2

摘要：Few cancers can be targeted efficiently by | engineered T cell strategies. Here, we show that gamma | delta T cell antigen receptor (gamma delta TCR | )-mediated cancer metabolome targeting can be combined with | targeting of cancer-associated stress antigens (such as

关键词： CUSTOMER SATISFACTION | SERVICE QUALITY | IMMUNE CELLS | ALPHA-BETA | SELECTION | ANTECEDENTS | INFERENCE | RESPONSES | BEHAVIOR | STIMULATION

10. Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral T reg cell differentiation NSTL国家科技图书文献中心

Lin, Liangyu | Hu, Mingyuan ... - 《Nature immunology》 - 2024,25(1) - 共35页 - 被引量：8

摘要：The nature of activation signals is essential | in determining T cell subset differentiation | ; however, the features that determine T cell subset | preference acquired during intrathymic development remain | elusive. Here we show that naive CD4(+) T cells