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1. The homeobox transcription factor DUXBL controls exit from totipotency NSTL国家科技图书文献中心

Vega-Sendino, Maria |  Luettmann, Felipe F.... -  《Nature Genetics》 - 2024,56(4) - 697~709 - 共13页 - 被引量:7

摘要:In mice, exit from the totipotent two-cell (2C | ) stage embryo requires silencing of the 2C-associated |  transcriptional program. However, the molecular mechanisms |  involved in this process remain poorly understood. Here |  we demonstrate that the 2C-specific transcription
关键词: ZYGOTIC GENOME ACTIVATION |  SUPER-ENHANCERS |  CELL IDENTITY |  WEB SERVER |  EXPRESSION |  CHROMATIN |  CONSERVATION |  ACETYLATION |  REPRESSION |  ELEMENTS

2. LINE-1 transcription activates long-range gene expression NSTL国家科技图书文献中心

Li, Xiufeng |  Bie, Luyao... -  《Nature Genetics》 - 2024,56(7) - 1494~1502 - 共9页 - 被引量:7

摘要:Long interspersed nuclear element-1 (LINE-1 or |  L1) is a retrotransposon group that constitutes 17 | % of the human genome and shows variable expression |  across cell types. However, the control of L1 |  expression and its function in gene regulation are
关键词: SET ENRICHMENT ANALYSIS |  GENOME |  ELEMENTS |  REVEALS |  RETROTRANSPOSITION |  ARCHITECTURE |  DATABASE |  COHESIN |  CTBP

3. Selection on synonymous sites: the unwanted transcript hypothesis NSTL国家科技图书文献中心

Radrizzani, Sofia |  Kudla, Grzegorz... -  《Nature reviews. Genetics》 - 2024,25(6) - 431~448 - 共18页 - 被引量:1

摘要:Although translational selection to favour |  codons that match the most abundant tRNAs is not |  readily observed in humans, there is nonetheless |  selection in humans on synonymous mutations. We |  hypothesize that much of this synonymous site selection can
关键词: MESSENGER-RNA |  CODON USAGE |  GENE-EXPRESSION |  PURIFYING SELECTION |  GC CONTENT |  EVOLUTIONARY CONSERVATION |  L1 RETROTRANSPOSITION |  NATURAL-SELECTION |  ESCHERICHIA-COLI |  DNA METHYLATION

4. The diversification of methods for studying cell-cell interactions and communication NSTL国家科技图书文献中心

Armingol, Erick |  Baghdassarian, Hratc...... -  《Nature reviews. Genetics》 - 2024,25(6) - 381~400 - 共20页 - 被引量:18

摘要:No cell lives in a vacuum, and the molecular |  interactions between cells define most phenotypes | . Transcriptomics provides rich information to infer cell-cell |  interactions and communication, thus accelerating the |  discovery of the roles of cells within their communities
关键词: SINGLE-CELL |  LIGAND-RECEPTOR |  GENE-EXPRESSION |  TOOL |  CHALLENGES |  PACKAGE

5. What tubulin can teach us about gene regulation NSTL国家科技图书文献中心

Rissland, Olivia S. -  《Nature reviews. Genetics》 - 2024,25(8) - 531~531 - 共1页

摘要:In this Journal Club article, Olivia Rissland |  describes how a 1987 paper by Don Cleveland and colleagues |  provided insight into co-translational gene regulation of |  tubulin.
关键词: DEGRADATION

6. Plant pangenomes for crop improvement, biodiversity and evolution NSTL国家科技图书文献中心

Schreiber, Mona |  Jayakodi, Murukarthi...... -  《Nature reviews. Genetics》 - 2024,25(8) - 563~577 - 共15页 - 被引量:19

摘要:Plant genome sequences catalogue genes and the |  genetic elements that regulate their expression. Such |  inventories further research aims as diverse as mapping the |  molecular basis of trait diversity in domesticated plants |  or inquiries into the origin of evolutionary
关键词: RESISTANCE GENE CLONING |  PAN-GENOME ANALYSIS |  STRUCTURAL VARIATION |  DISEASE RESISTANCE |  ARABIDOPSIS |  WILD |  DOMESTICATION |  DIVERSITY |  DIFFERENTIATION |  CONSERVATION

7. Principles and methods for transferring polygenic risk scores across global populations NSTL国家科技图书文献中心

Hirbo, Jibril |  Schaid, Daniel J.... -  《Nature reviews. Genetics》 - 2024,25(1) - 8~25 - 共18页 - 被引量:38

摘要:Polygenic risk scores (PRSs) summarize the |  genetic predisposition of a complex human trait or |  disease and may become a valuable tool for advancing |  precision medicine. However, PRSs that are developed in |  populations of predominantly European genetic ancestries can
关键词: MODELING LINKAGE DISEQUILIBRIUM |  GENETIC ANCESTRY |  BREAST-CANCER |  PREDICTION |  DISEASE |  INFERENCE |  HEALTH |  PERFORMANCE |  COMPONENTS |  ACCURACY

8. DNA packaging by molecular motors: from bacteriophage to human chromosomes NSTL国家科技图书文献中心

Prevo, Bram |  Earnshaw, William C. -  《Nature reviews. Genetics》 - 2024,25(11) - 785~802 - 共18页

摘要:Dense packaging of genomic DNA is crucial for |  organismal survival, as DNA length always far exceeds the |  dimensions of the cells that contain it. Organisms | , therefore, use sophisticated machineries to package their |  genomes. These systems range across kingdoms from a
关键词: ESCHERICHIA-COLI CHROMOSOME |  X-RAY-DIFFRACTION |  TOPOISOMERASE-II |  LOOP EXTRUSION |  PORTAL MOTOR |  3-DIMENSIONAL ARCHITECTURE |  INTERPHASE CHROMATIN |  ELECTRON-MICROSCOPY |  FOLDED CHROMOSOMES |  FORCE GENERATION

9. Targeting and engineering long non-coding RNAs for cancer therapy NSTL国家科技图书文献中心

Coan, Michela |  Haefliger, Simon... -  《Nature reviews. Genetics》 - 2024,25(8) - 578~595 - 共18页 - 被引量:28

摘要:RNA therapeutics (RNATx) aim to treat diseases | , including cancer, by targeting or employing RNA molecules |  for therapeutic purposes. Amongst the most promising |  targets are long non-coding RNAs (lncRNAs), which |  regulate oncogenic molecular networks in a cell type
关键词: ANTISENSE OLIGONUCLEOTIDES |  GENE-EXPRESSION |  UP-REGULATION |  CELL-PROLIFERATION |  HEPATOCELLULAR-CARCINOMA |  EVOLUTIONARY DYNAMICS |  LIPID NANOPARTICLES |  CERVICAL-CANCER |  POOR-PROGNOSIS |  BINDING-SITES

10. Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements NSTL国家科技图书文献中心

Krupina, Ksenia |  Goginashvili, Alexan...... -  《Nature reviews. Genetics》 - 2024,25(3) - 196~210 - 共15页 - 被引量:10

摘要:Complex chromosome rearrangements, known as |  chromoanagenesis, are widespread in cancer. Based on large-scale |  DNA sequencing of human tumours, the most frequent |  type of complex chromosome rearrangement is |  chromothripsis, a massive, localized and clustered
关键词: ACUTE MYELOID-LEUKEMIA |  CYCLIC GMP-AMP |  DNA-DAMAGE |  MUTATIONAL SIGNATURES |  UTERINE LEIOMYOMAS |  CHROMOTHRIPSIS |  EVOLUTION |  ABNORMALITIES |  MICRONUCLEI |  MECHANISMS
检索条件出处:Nature Genetics
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