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1. Exploring Brain Imaging and Genetic Risk Factors in Different Progression States of Alzheimer's Disease Through OSnetNMF-Based Methods NSTL国家科技图书文献中心

Gao, Min |  Kong, Wei... -  《Journal of Molecular Neuroscience》 - 2025,75(1) - Article: 7~Article: 7 - 共20页

摘要:Alzheimer's disease (AD) is a |  neurodegenerative disease with no effective treatment, often |  preceded by mild cognitive impairment (MCI). Multimodal |  imaging genetics integrates imaging and genetic data to |  gain a deeper understanding of disease progression
关键词: Alzheimer's disease (AD) |  Multimodal imaging genetics |  Network-based non-negative matrix factorization (netNMF)

2. Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease NSTL国家科技图书文献中心

Virve,Kärkkäinen |  Toni,Saari... -  《Journal of Molecular Neuroscience》 - 2025,75(2) - Article: 73~Article: 73 - 共11页

摘要:Abstract The protein composition of tear fluid |  (TF) reflects the severity and progression of many |  age-related diseases. Here, we evaluated TF proteins |  from patients with mild Alzheimer’s disease (AD) and |  cognitively healthy controls (CO) to explore potential new
关键词: Alzheimer’s disease (AD) |  Tear fluid (TF) |  Proteomics |  AD pathophysiology |  Inflammation |  Biomarkers |  Koivisto AM and Utheim TP share the last authorship.

3. Causal Association Between Sleep Deprivation and Glioblastoma Risk: Insights from Multi-Omics Analysis NSTL国家科技图书文献中心

Du, Runze |  Maierdan, Mulade... -  《Journal of Molecular Neuroscience》 - 2025,75(2) - Article: 56~Article: 56 - 共15页

摘要:Emerging evidence suggests that sleep |  deprivation may contribute to cancer risk. However, the |  genetic association between sleep deprivation and |  glioblastoma (GBM) remains unexplored. This study aimed to |  investigate the causal relationship between sleep traits and
关键词: Glioblastoma |  Sleep duration |  Immunity |  Mendelian randomization |  Pathogenesis

4. Metabolic Reprogramming in Spinal Cord Injury and Analysis of Potential Therapeutic Targets NSTL国家科技图书文献中心

Chen, Xiangjun |  Wang, Juan... -  《Journal of Molecular Neuroscience》 - 2025,75(2) - Article: 50~Article: 50 - 共20页

摘要:Spinal cord injury (SCI) is a critical |  neurological disorder that frequently leads to permanent |  disability, profoundly affecting the quality of life of |  individuals with SCI. In this research, we examined the |  varied expression of genes associated with metabolic
关键词: Spinal cord injury |  Metabolic reprogramming |  GO |  KEGG |  Immune infiltration |  Quantitative real-time PCR

5. Navigating Uncertainty: Assessing Variants of Uncertain Significance in the CDKL5 Gene for Developmental and Epileptic Encephalopathy Using In Silico Prediction Tools and Computational Analysis NSTL国家科技图书文献中心

Capan, Ozlem Yalcin -  《Journal of Molecular Neuroscience》 - 2025,75(1) - Article: 19~Article: 19 - 共24页

摘要:Mutations in the CDKL5 gene are associated |  with developmental and epileptic encephalopathy (DEE | ), a severe disorder characterized by developmental |  delay and epileptic activity. In genetic analyses of |  DEEs, variants classified as pathogenic confirm the
关键词: CDKL5 |  Variants of uncertain significance (VUS) |  Developmental and Epileptic Encephalopathy |  In silico prediction tools |  SNPred |  Missens3D |  Molecular Dynamic Simulations

6. Plasma Extracellular Matrix Protein 2 Level as a Predictive Biomarker for Rupture of Small Intracranial Aneurysms NSTL国家科技图书文献中心

Chenchen,Wang |  Yuwei,Han... -  《Journal of Molecular Neuroscience》 - 2025,75(1) - Article: 33~Article: 33 - 共9页

摘要:Abstract As the neuroimaging technology |  improves, the detection rate of unruptured intracranial |  aneurysms (UIA) is gradually increasing. However, there is |  currently no effective means to evaluate and predict the |  risk of rupture for small intracranial aneurysm (sIA
关键词: Small intracranial aneurysm |  Subarachnoid hemorrhage |  Rupture risk |  Plasma biomarker |  Extracellular matrix protein 2

7. Chitinase-3 Like-Protein-1 Signature in Neurological Disorders: Emphasis on Stroke NSTL国家科技图书文献中心

Khiany,Mathias |  Richard Simon,Machad...... -  《Journal of Molecular Neuroscience》 - 2025,75(1) - Article: 25~Article: 25 - 共10页

摘要:Abstract Chitinase-3 like-protein-1 (CHI3L1 | ) is a protein involved in various pathological |  conditions, including infectious, allergic, metabolic | , cardiovascular, and neurological diseases. In the central |  nervous system, glial cells, especially activated
关键词: Stroke |  CHI3L1 |  YKL-40 |  Neurological Diseases

8. Identification of Novel Biomarkers for Ischemic Stroke Through Integrated Bioinformatics Analysis and Machine Learning NSTL国家科技图书文献中心

Jia, Juan |  Niu, Liang... -  《Journal of Molecular Neuroscience》 - 2025,75(1) - Article: 13~Article: 13 - 共17页 - 被引量:1

摘要:Ischemic stroke leads to permanent damage to |  the affected brain tissue, with strict time |  constraints for effective treatment. Predictive biomarkers |  demonstrate great potential in the clinical diagnosis of |  ischemic stroke, significantly enhancing the accuracy of
关键词: Ischemic stroke |  Bioinformatics |  Machine learning |  Immunity |  Vimentin

9. α7-Nicotinic Acetylcholine Receptor Activation Modulates BV2 Microglial Plasticity via miR-21/TNF-α/NFκB in Oxygen–Glucose Deprivation/Reoxygenation NSTL国家科技图书文献中心

Mohammad Yusuf,Hasan |  Azim Haikal Md,Rosla...... -  《Journal of Molecular Neuroscience》 - 2025,75(1) - Article: 2~Article: 2 - 共13页

摘要:Abstract Elevated inflammatory reactions are a |  significant component in cerebral ischemia–reperfusion |  injury (CIRI). Activation of α7-Nicotinic Acetylcholine |  Receptor (α7nAChR) reduces stroke-induced inflammation in |  rats, but the anti-inflammatory pathway in microglia
关键词: Neuroinflammation |  Mir-21 |  Ischemia–reperfusion injury |  Oxygen–glucose deprivation and reoxygenation |  BV2

10. From Genetics to Function: the Role of ABCA12 in Autism Neurobiology NSTL国家科技图书文献中心

Akansha,Pal |  Falguni,Goel... -  《Journal of Molecular Neuroscience》 - 2025,75(2) - Article: 67~Article: 67 - 共13页

摘要:Abstract ASD is a complex neurodevelopmental |  disorder with genetic, environmental, and molecular roots | . Among the thousands of genes that have been associated |  with ASD, one critical factor has emerged as ABCA12 | , which plays an important role in lipid transport and
关键词: ABCA12 |  Autism |  Genetics |  Neurodevelopmental disorder
检索条件出处:Journal of Molecular Neuroscience
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