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1. Metabolic reprogramming in liver fibrosis NSTL国家科技图书文献中心

Horn, Paul |  Tacke, Frank -  《Cell metabolism》 - 2024,36(7) - 1439~1455 - 共17页 - 被引量:15

摘要:Chronic liver diseases, primarily metabolic |  dysfunction-associated steatotic liver disease (MASLD | ), harmful use of alcohol, or viral hepatitis, may result |  in liver fibrosis, cirrhosis, and cancer. Hepatic |  fibrogenesis is a complex process with interactions between
关键词: HEPATIC STELLATE CELLS |  PYRUVATE-KINASE M2 |  FREE-CHOLESTEROL ACCUMULATION |  UNFOLDED PROTEIN RESPONSE |  KUPFFER CELLS |  NONALCOHOLIC STEATOHEPATITIS |  LIPID-METABOLISM |  CONTROLLED-TRIAL |  C/EBP-BETA |  ACTIVATION

2. Glycine homeostasis requires reverse SHMT flux NSTL国家科技图书文献中心

McBride, Matthew J. |  Hunter, Craig J.... -  《Cell metabolism》 - 2024,36(1) - 103~115 - 共13页 - 被引量:5

摘要:The folate-dependent enzyme serine |  hydroxymethyltransferase (SHMT) reversibly converts serine into glycine |  and a tetrahydrofolate-bound one -carbon unit. Such |  one -carbon unit production plays a critical role in |  development, the immune system, and cancer. Using rodent
关键词: ONE-CARBON METABOLISM |  NONALCOHOLIC STEATOHEPATITIS |  SERINE BIOSYNTHESIS |  REACTION-MECHANISM |  CLEAVAGE SYSTEM |  CELL |  NUTRITION |  TURNOVER |  LIVER |  MASS

3. A microbial metabolite inhibits the HIF-2a-ceramide a-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH NSTL国家科技图书文献中心

Zhang, Yi |  Wang, Xuemei... -  《Cell metabolism》 - 2024,36(8) - 1823~1838 - 共16页 - 被引量:2

摘要:Time-restricted feeding (TRF) is a potent |  dietary intervention for improving metabolic diseases | , including metabolic dysfunction-associated steatotic liver |  disease/metabolic dysfunction-associated steatohepatitis |  (MASLD/MASH). However, the mechanism of this efficacy
关键词: FATTY LIVER-DISEASE |  INDUCIBLE FACTOR 2-ALPHA |  GUT MICROBIOME |  BACTERIA |  NASH

4. A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis NSTL国家科技图书文献中心

Dong, Yimin |  Kang, Honglei... -  《Cell metabolism》 - 2024,36(8) - 1679~1695 - 共17页 - 被引量:5

摘要:Activating Nrf2 by small molecules is a |  promising strategy to treat postmenopausal osteoporosis | . However, there is currently no Nrf2 activator approved |  for treating chronic diseases, and the downstream |  mechanism underlying the regulation of Nrf2 on osteoclast
关键词: NEGATIVE SYMPTOMS |  BITOPERTIN |  GLYCINE |  SCHIZOPHRENIA |  EFFICACY |  STRESS |  SAFETY

5. H 2 S serves as the immunoregulatory essence of apoptotic cell death NSTL国家科技图书文献中心

Hine, Christopher |  Ponti, Andras K.... -  《Cell metabolism》 - 2024,36(1) - 3~5 - 共3页

摘要:Apoptosis supports tissue homeostasis and |  prevents immune disorders by removing damaged and |  functionally aberrant cells. Here, Ou et al. utilized genetic | , pharmacological, and proteomic approaches focused on sulfur |  amino acid catabolism to discover that hydrogen
关键词: HYDROGEN-SULFIDE

6. Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor NSTL国家科技图书文献中心

Regmi, Ajit |  Aihara, Eitaro... -  《Cell metabolism》 - 2024,36(7) - 1534~1549 - 共16页 - 被引量:11

摘要:Tirzepatide, a glucose-dependent |  insulinotropic polypeptide/glucagon-like peptide 1 receptor |  (GIPR/GLP1R) agonist, has, in clinical trials | , demonstrated greater reductions in glucose, body weight, and |  triglyceride levels compared with selective GLP-1R agonists
关键词: DEPENDENT INSULINOTROPIC POLYPEPTIDE |  GASTRIC-INHIBITORY POLYPEPTIDE |  ADIPOSE-TISSUE |  LIPOPROTEIN-LIPASE |  BODY-WEIGHT |  DUAL GIP |  IN-VIVO |  GLUCOSE |  EXPRESSION |  LIPOLYSIS

7. Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation NSTL国家科技图书文献中心

Zhou, Jian |  Zhang, Lifang... -  《Cell metabolism》 - 2024,36(9) - 2054~2068 - 共15页

摘要:Low-density lipoprotein receptor-related |  protein-1 (LRP1) is an endocytic/signaling cell-surface |  receptor that regulates diverse cellular functions | , including cell survival, differentiation, and |  proliferation. LRP1 has been previously implicated in the
关键词: RECEPTOR-RELATED PROTEIN-1 |  GLUCOSE-METABOLISM |  LACTATE |  EXPRESSION |  INJURY |  PATHOGENESIS |  INFLAMMATION |  HOMEOSTASIS |  TRANSPORT |  INSULIN

8. Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience NSTL国家科技图书文献中心

Yan, Lan |  Wang, Yajie... -  《Cell metabolism》 - 2024,36(9) - 2104~2117 - 共14页

摘要:Lactate is a critical metabolite during the |  body's adaption to exercise training, which effectively |  relieves anxiety-like disorders. The biological mechanism |  of lactate in the exercise-mediated anxiolytic |  effect has, however, not been comprehensively
关键词: CLATHRIN BINDING |  LACTATE |  AP180 |  DYSFUNCTION |  DISORDER |  DOMAIN |  BRAIN |  CALM

9. Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease NSTL国家科技图书文献中心

Kolic, Jelena |  Sun, WenQing Grace... -  《Cell metabolism》 - 2024,36(7) - 1619~1633 - 共15页 - 被引量:4

摘要:Population-level variation and mechanisms |  behind insulin secretion in response to carbohydrate | , protein, and fat remain uncharacterized. We defined |  prototypical insulin secretion responses to three |  macronutrients in islets from 140 cadaveric donors, including
关键词: FREE FATTY-ACIDS |  GLUCOSE-METABOLISM |  HUMAN ISLETS |  INFUSION |  RAT

10. Quantification of nutrient fluxes during acute exercise in mice NSTL国家科技图书文献中心

Axsom, Jessie |  Teslaa, Tara... -  《Cell metabolism》 - 2024,36(12) - 2560~2579.e5 - 共26页 - 被引量:1

摘要:Despite the known metabolic benefits of |  exercise, an integrated metabolic understanding of |  exercise is lacking. Here, we use in vivo steady-state |  isotope-labeled infusions to quantify fuel flux and |  oxidation during exercise in fasted, fed, and exhausted
关键词: TCA cycle; circulating metabolites; energy metabolism; exercise; in vivo flux
检索条件出处:Cell metabolism

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