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1. Crystal structures of NAD(P)H nitroreductases from Klebsiella pneumoniae NSTL国家科技图书文献中心

Abhishek D. Kancherl... | Lijun Liu ... - 《Acta crystallographica. Section F, Structural biology communications》 - 2024,80(8) - 173～182 - 共10页

摘要：Klebsiella pneumoniae (Kp) is an infectious | disease pathogen that poses a significant global health | threat due to its potential to cause severe infections | and its tendency to exhibit multidrug resistance | . Understanding the enzymatic mechanisms of the oxygen

关键词： nitroreductases | Klebsiella pneumoniae | SSGCID | structural genomics | Seattle Structural Genomics Center for Infectious Disease | oxidoreductases

2. Crystal structures of the 3C proteases from Coxsackievirus B3 and B4 NSTL国家科技图书文献中心

Haihai Jiang | Cheng Lin ... - 《Acta crystallographica. Section F, Structural biology communications》 - 2024,80(8) - 183～190 - 共8页

摘要：Enteroviruses cause a wide range of disorders | with varying presentations and severities, and some | enteroviruses have emerged as serious public health concerns | . These include Coxsackievirus B3 (CVB3), an active | causative agent of viral myocarditis, and Coxsackievirus

关键词： Coxsackievirus | CVB3 | CVB4 | 3C proteases | crystal structure

3. Crystal structure of the GDP-bound human M-RAS protein in two crystal forms NSTL国家科技图书文献中心

Stephanie M. Bester | Rebecca Abrahamsen ... - 《Acta crystallographica. Section F, Structural biology communications》 - 2024,80(9) - 220～227 - 共8页

摘要：M-RAS plays a crucial role in the RAF–MEK | signaling pathway. When activated by GTP, M-RAS forms a | complex with SHOC2 and PP1C, initiating downstream RAF | –MEK signal transduction. In this study, the crystal | structure of the GDP-bound human M-RAS protein is

关键词： M-RAS | GDP | GTPase structure | crystal packing

4. Welcoming Alejandro Buschiazzo, Dorothee Liebschner and Stephen Muench as Co‐editors of Acta Crystallographica F – Structural Biology Communications NSTL国家科技图书文献中心

Jon Agirre | Maria Cristina Nonat...... - 《Acta crystallographica. Section F, Structural biology communications》 - 2024,80(10) - 234～235 - 共2页

摘要：The Section Editors welcome and introduce | three new Co‐editors to the journal and summarize | their expertise in computational structural biology | , experimental structural biology and cryo‐electron microscopy.

关键词： Co‐editors | structural biology | microbiology | software | cryo‐electron microscopy

5. The unbearable burden of peer review? NSTL国家科技图书文献中心

Mark J. van Raaij - 《Acta crystallographica. Section F, Structural biology communications》 - 2024,80(3) - 52～52 - 共1页

摘要：In conversations between researchers and on | social networks the slowness and pickiness of peer | reviewing is often decried. Journal editors often have | difficulty securing the desired number of reviews for a | manuscript. Anecdotal evidence suggests that some

关键词： peer review

6. Crystal structure of the RNA‐recognition motif of Drosophila melanogaster tRNA (uracil‐5‐)‐methyltransferase homolog A NSTL国家科技图书文献中心

Monika Witzenberger | Robert Janowski ... - 《Acta crystallographica. Section F, Structural biology communications》 - 2024,80(2) - 36～42 - 共7页

摘要：Human tRNA (uracil‐5‐)‐methyltransferase 2 | homolog A (TRMT2A) is the dedicated enzyme for the | methylation of uridine 54 in transfer RNA (tRNA). Human | TRMT2A has also been described as a modifier of | polyglutamine (polyQ)‐derived neuronal toxicity. The

关键词： RRMs | TRMT2A | methyltransferases | X‐ray crystallography | Drosophila melanogaster | neurodegenerative disease

7. Crystal structure of the Rib domain of the cell-wallanchored surface protein from Limosilactobacillus reuteri NSTL国家科技图书文献中心

Yi Xue | Zhen Wu ... - 《Acta crystallographica. Section F, Structural biology communications》 - 2024,80(9) - 228～233 - 共6页

摘要：The immunoglobulin (Ig)-like domain is found | in a broad range of proteins with diverse | functional roles. While an essential β-sandwich fold is | maintained, considerable structural variations exist and | are critical for functional diversity. The Rib

关键词： X-ray crystallography | Rib domains | Limosilactobacillus reuteri | immunoglobulinlike fold | bacterial adhesins

8. Crystal structure and biophysical characterization of IspD from Burkholderia thailandensis and Mycobacterium paratuberculosis NSTL国家科技图书文献中心

Phillip G. Pierce | Brian E. Hartnett ... - 《Acta crystallographica. Section F, Structural biology communications》 - 2024,80(2) - 43～51 - 共9页

摘要：The methylerythritol phosphate (MEP) pathway | is a metabolic pathway that produces the | isoprenoids isopentyl pyrophosphate and dimethylallyl | pyrophosphate. Notably, the MEP pathway is present in bacteria | and not in mammals, which makes the enzymes of the

关键词： IspD | Burkholderia thailandensis | Mycobacterium paratuberculosis | transferases | cytidylyltransferases | structural genomics | Seattle Structural Genomics Center for Infectious Disease | SSGCID

9. Glucose‐6‐phosphate dehydrogenase and its 3D structures from crystallography and electron cryo‐microscopy NSTL国家科技图书文献中心

Stefania Hanau | John R. Helliwell - 《Acta crystallographica. Section F, Structural biology communications》 - 2024,80(10) - 236～251 - 共16页

摘要：Glucose‐6‐phosphate dehydrogenase (G6PD) is | the first enzyme in the pentose phosphate pathway | . It has been extensively studied by biochemical and | structural techniques. 13 X‐ray crystal structures and five | electron cryo‐microscopy structures in the PDB are

关键词： glucose‐6‐phosphate dehydrogenase | X‐ray crystallography | electron cryo‐microscopy | fused glucose‐6‐phosphate dehydrogenase–6‐phosphogluconolactonase | F420‐dependent glucose‐6‐phosphate dehydrogenase | human and trypanosomatid species

10. Structural analysis of the FERM domain of human protein tyrosine phosphatase non‐receptor type 21 NSTL国家科技图书文献中心

Hye Seon Lee | Bonsu Ku ... - 《Acta crystallographica. Section F, Structural biology communications》 - 2024,80(7) - 148～153 - 共6页

摘要：Protein tyrosine phosphatase non‐receptor type | 21 (PTPN21) is a cytosolic protein tyrosine | phosphatase that regulates cell growth and invasion. Due to | its oncogenic properties, PTPN21 has recently | emerged as a potential therapeutic target for cancer. In

摘要：Klebsiella pneumoniae (Kp) is an infectious | disease pathogen that poses a significant global health | threat due to its potential to cause severe infections | and its tendency to exhibit multidrug resistance | . Understanding the enzymatic mechanisms of the oxygen

关键词： nitroreductases | Klebsiella pneumoniae | SSGCID | structural genomics | Seattle Structural Genomics Center for Infectious Disease | oxidoreductases

摘要：Enteroviruses cause a wide range of disorders | with varying presentations and severities, and some | enteroviruses have emerged as serious public health concerns | . These include Coxsackievirus B3 (CVB3), an active | causative agent of viral myocarditis, and Coxsackievirus

关键词： Coxsackievirus | CVB3 | CVB4 | 3C proteases | crystal structure

摘要：M-RAS plays a crucial role in the RAF–MEK | signaling pathway. When activated by GTP, M-RAS forms a | complex with SHOC2 and PP1C, initiating downstream RAF | –MEK signal transduction. In this study, the crystal | structure of the GDP-bound human M-RAS protein is

关键词： M-RAS | GDP | GTPase structure | crystal packing

摘要：The Section Editors welcome and introduce | three new Co‐editors to the journal and summarize | their expertise in computational structural biology | , experimental structural biology and cryo‐electron microscopy.

关键词： Co‐editors | structural biology | microbiology | software | cryo‐electron microscopy

摘要：In conversations between researchers and on | social networks the slowness and pickiness of peer | reviewing is often decried. Journal editors often have | difficulty securing the desired number of reviews for a | manuscript. Anecdotal evidence suggests that some

关键词： peer review

摘要：Human tRNA (uracil‐5‐)‐methyltransferase 2 | homolog A (TRMT2A) is the dedicated enzyme for the | methylation of uridine 54 in transfer RNA (tRNA). Human | TRMT2A has also been described as a modifier of | polyglutamine (polyQ)‐derived neuronal toxicity. The

关键词： RRMs | TRMT2A | methyltransferases | X‐ray crystallography | Drosophila melanogaster | neurodegenerative disease

摘要：The immunoglobulin (Ig)-like domain is found | in a broad range of proteins with diverse | functional roles. While an essential β-sandwich fold is | maintained, considerable structural variations exist and | are critical for functional diversity. The Rib

关键词： X-ray crystallography | Rib domains | Limosilactobacillus reuteri | immunoglobulinlike fold | bacterial adhesins

摘要：The methylerythritol phosphate (MEP) pathway | is a metabolic pathway that produces the | isoprenoids isopentyl pyrophosphate and dimethylallyl | pyrophosphate. Notably, the MEP pathway is present in bacteria | and not in mammals, which makes the enzymes of the

关键词： IspD | Burkholderia thailandensis | Mycobacterium paratuberculosis | transferases | cytidylyltransferases | structural genomics | Seattle Structural Genomics Center for Infectious Disease | SSGCID

摘要：Glucose‐6‐phosphate dehydrogenase (G6PD) is | the first enzyme in the pentose phosphate pathway | . It has been extensively studied by biochemical and | structural techniques. 13 X‐ray crystal structures and five | electron cryo‐microscopy structures in the PDB are

关键词： glucose‐6‐phosphate dehydrogenase | X‐ray crystallography | electron cryo‐microscopy | fused glucose‐6‐phosphate dehydrogenase–6‐phosphogluconolactonase | F420‐dependent glucose‐6‐phosphate dehydrogenase | human and trypanosomatid species

摘要：Protein tyrosine phosphatase non‐receptor type | 21 (PTPN21) is a cytosolic protein tyrosine | phosphatase that regulates cell growth and invasion. Due to | its oncogenic properties, PTPN21 has recently | emerged as a potential therapeutic target for cancer. In

关键词： protein tyrosine phosphatase non‐receptor type 21 | PTPN21 | FERM domains | protein‐binding selectivity | crystal structure | cancer therapy

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