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1. Investigating Conserved Structure-Function Relationships and Mechanistic Aspects of SufS, a Type II Cysteine Desulfurase NSTL国家科技图书文献中心

Gogar, Rajleen Kaur. -  Biochemistry.;Microb... -  Ph.D. -  Frantom, Patrick A. - 2024, - 1～157 - 共157页

摘要： sulfur from L-cysteine by enzymes known as cysteine |  desulfurases. SufS is a type II cysteine desulfurase that |  pathway in E. coli. Like all cysteine desulfurases, SufS | -cysteine. As a type II cysteine desulfurase, SufS |  extended to other type II cysteine desulfurases and
关键词： Cysteine desulfurases |  Escherichia coli |  Iron-sulfur cluster assembly |  Pre-steady state kinetics |  SufS conserved features
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2. Cysteine Arylation via Unconventional Nucleophilic Aromatic Substitution NSTL国家科技图书文献中心

Bassett, Gregory. -  Chemistry.;Inorganic... -  M.S. -  Wang, Fang - 2024, - 1～37 - 共37页

摘要： effective cysteine arylation with rapid kinetics and |  stable cysteine bioconjugates. However, the |  with cysteine was relatively slow and unsuitable for |  effective cysteine functionalization. To overcome this |  cysteine using para-nitropyridine-borane adducts. We
关键词： Bioconjugation |  Organic Chemistry
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3. Studies in Natural Product Discovery and Total Synthesis: Towards (1) Tambromycin and Analogs and (2) Cysteine Containing Natural Products NSTL国家科技图书文献中心

Da Silva, Israel. -  Organic chemistry.;B... -  Ph.D. -  Thomson, Regan J. |  Kelleher, Neil - 2024, - 1～137 - 共137页

摘要： revolves around the targeted discovery of cysteine |  cysteine and on metabolites predicted to give a cysteine |  bioactivity. Compounds containing cysteine can undergo |  derived from cysteine, this targeted approach leverages |  the inherent versatility of cysteine-derived
关键词： Tambromycin |  Mass spectrometry |  Natural products |  Synthetic chemistry |  Cysteine
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4. Exploring the Potential Roles of Extracellular Vesicles (EVs) as Biomarkers and Their Involvement in the Pathogenesis of the Early Phase of Snake Envenomation by Crotalus scutulatus scutulatus Crude Venom and Its Purified Cysteine-Rich Secretory Protein (Css-CRiSP) NSTL国家科技图书文献中心

Reyes, Armando. -  Biochemistry.;Chemis... -  M.S. -  Suntravat, Montamas - 2024, - 1～79 - 共79页

摘要： critical role of cysteine-rich secretory proteins (CRiSPs | The venoms of viperid snakes encompass a wide |  array of toxins capable of inducing diverse local and |  systemic effects, thus resulting in varied clinical |  manifestations. Our previous research has highlighted the
关键词： Cysteine-rich secretory proteins (CRiSPs) |  Endothelial permeability |  Extracellular vesicles |  Inflammatory cytokines |  Proteomic analysis |  Snakebites
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5. Functional Studies of Amino Acid Transporters from the Solute Carrier SLC1 and SLC38 Families NSTL国家科技图书文献中心

Dong, Yang. -  Chemistry. -  Ph.D. -  Grewer, Christof - 2024, - 1～216 - 共216页

摘要： damage. Alanine serine cysteine transporter 2 (ASCT2 | Excitatory amino acid transporter 1 (EAAT1) is |  critical in modulating signals from glutamate, the major |  excitatory neurotransmitter. The uptake of one glutamate by |  EAAT1 is coupled to the co-transport of three Na+ ions
关键词： Excitatory amino acid transporter 1 |  Amino acid |  Glutamate |  EAAT1 |  Alanine serine cysteine transporter 2 |  ASCT2
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6. The Expression of Recombinant Cas9 Proteins in E. coli BL21(DE3) Strains NSTL国家科技图书文献中心

Reese, Morgan. -  Molecular biology.;M... -  M.S. -  Nelson, Christopher ... - 2024, - 1～44 - 共44页

摘要： cysteine modified Cas9. Our comparison shows that BL21 |  Cystine modified SpCas9 (Cys-Cas9) to test and validate | Extensively used for genome editing, CRISPR | -Cas9 is a relatively new tool that has made a major |  impact in the genomic engineering landscape. Due to
关键词： Recombinant proteins |  Bacterial strains |  Genome editing |  Cleavage efficiency |  Protein purification
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7. Expression of Ubiquitin Ligase NKLAM/RNF19B Inhibits Cell Proliferation and Promotes Apoptosis NSTL国家科技图书文献中心

Willard, Paul A. -  Pathology.;Cellular ... -  Ph.D. -  Kornbluth, Jacki - 2024, - 1～75 - 共75页

摘要：, we identified a critical cysteine residue at | Natural Killer Lytic Associated Molecule |  (NKLAM), a member of the RBR E3 ubiquitin ligase family | , plays a pivotal role in cellular homeostasis and |  immune regulation. Through site-directed mutagenesis
关键词： Natural Killer Lytic Associated Molecule |  NKLAM |  RBR |  RNF19B |  Ubiquitin ligase
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8. Cucurbituril-Secured Pt(II) Terpyridine Complexes: Design and Applications NSTL国家科技图书文献中心

Thompson, Nathan A. -  Chemistry.;Organic c... -  Ph.D. -  Masson, Eric - 2024, - 1～244 - 共244页

摘要： simultaneously bind cysteine and histidine residues in peptides | Cucurbit[n]urils (CB[n]s) are a family of |  supramolecular hosts known for their ability to bind |  hydrophobic, cationic guests with high affinity in aqueous |  solutions. While CB[7] and smaller members of the family
关键词： Supramolecular chemistry |  Organometallic chemistry |  Cucurbiturils |  Platinum |  Terpyridine
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9. Discovery of Small Molecule Drugs Against Crucial Proteins, Papain-Like Protease (PLpro) and Non-Structural Protein 15 (Nsp15), From SARS-CoV-2 Virus NSTL国家科技图书文献中心

Bajaj, Teena. -  Biochemistry.;Cellul... -  Ph.D. -  Murthy, Niren - 2024, - 1～67 - 共67页

摘要： cysteine-binding inhibitors. This discovered a new class | The emergence and rapid spread of the severe |  acute respiratory syndrome coronavirus 2, SARS-CoV-2 |  (SCoV-2) caused catastrophic levels of morbidity in |  the world and presented the unmet need for
关键词： Papain-like protease |  Mercaptopyrimidine |  Covalent inhibitors
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10. Method and Ionization Source Development for Mass Spectrometry Imaging NSTL国家科技图书文献中心

Goodenough, Andrew K... -  Analytical chemistry... -  Ph.D. -  Basile, Franco - 2024, - 1～164 - 共164页

摘要：-terminus of aspartic acid and N-terminus of cysteine by | Mass spectrometry imaging (MSI) provides |  spatially resolved information on the molecular |  composition of a wide range of samples. Methods and |  instrumentation are continually being developed to improve the
关键词： Bombus impatiens |  Mass spectrometry imaging |  Thermal decomposition |  Gas chromatography |  Bumblebee
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