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1. Expression of Ubiquitin Ligase NKLAM/RNF19B Inhibits Cell Proliferation and Promotes Apoptosis NSTL国家科技图书文献中心

Willard, Paul A. - Pathology.;Cellular ... - Ph.D. - Kornbluth, Jacki - 2024, - 1～75 - 共75页

摘要：Natural Killer Lytic Associated Molecule (NKLAM), a member of the RBR E3 ubiquitin ligase family, plays a pivotal role in cellular homeostasis and immune regulation. Through site-directed mutagenesis,...

关键词： Natural Killer Lytic Associated Molecule | NKLAM | RBR | RNF19B | Ubiquitin ligase

2. The ubiquitin ligase NKLAM promotes apoptosis and suppression of cell growth

Willard, Paul A. | Kornbluth, Jacki - 《journal of biological chemistry》 - 2025,301(6) - 共14页

摘要：Natural killer lytic-associated molecule (NKLAM), also known as RNF19b, is a member of the RING-in between-RING-RING (RBR) E3 ubiquitin ligase family and plays a pivotal role in immune regulation. We ...

关键词： LYTIC-ASSOCIATED MOLECULE | MYC PROTEIN STABILITY | TUMOR-CELLS | GRANZYME | CYTOTOXICITY | EXPRESSION | PROTECTION | REVEALS | PATHWAY | PARKIN

3. Natural Killer Lytic-Associated Molecule (NKLAM): An E3 Ubiquitin Ligase With an Integral Role in Innate Immunity

Lawrence, Donald W. | Willard, Paul A.... - 《frontiers in physiology》 - 2020,11 - 共13页

摘要：Natural Killer Lytic-Associated Molecule (NKLAM), also designated RNF19B, is a unique member of a small family of E3 ubiquitin ligases. This 14-member group of ligases has a characteristic cysteine-ri...

关键词： NKLAM | ubiquitin ligase | innate immunity | natural killer | macrophage | phagocytosis | cytotoxicity | RNF19B | RNA-BINDING PROTEINS | GENE-EXPRESSION...

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作者：Willard, Paul A.

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