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1. Minor role of TP53 and TERT promoter mutations in medullary thyroid carcinoma: report of new cases and revision of the literature NSTL国家科技图书文献中心

Casalini, Roberta | Romei, Cristina ... - 《Endocrine.》 - 2025,87(1) - 243～251 - 共9页

摘要：Purpose Aims of this study were to investigate the prevalence of TP53 and TERT mutations in Medullary Thyroid carcinoma (MTC) and their role in inducing aggressiveness in positive cases. Methods We pe...

关键词： TP53 | TERT | Medullary thyroid cancer | Oncogene | Tumor suppressor gene

2. Molecular Profiling of Low-Risk Papillary Thyroid Carcinoma (mPTC) on Active Surveillance NSTL国家科技图书文献中心

Ramone, Teresa | Ghirri, Arianna ... - 《The Journal of Clinical Endocrinology and Metabolism》 - 2025,110(3) - 685～692 - 共8页

摘要：Context The active surveillance (AS) program for papillary thyroid carcinoma (<= 1 cm) at low risk (mPTC) showed a low percentage of progression.Objective The aim of this study was to find a molecular...

关键词： active surveillance | molecular profile | mPTC | NGS | progression

3. NF1 gene inactivation acts as a tumor driver in RET/RAS-negative medullary thyroid carcinomas NSTL国家科技图书文献中心

Ciampi, Raffaele | Ramone, Teresa ... - 《European journal of endocrinology》 - 2023,188(5) - 430～437 - 共8页

摘要：Objective About 20% of sporadic medullary thyroid carcinomas (MTC) have no RET/RAS somatic alterations or other known gene alterations. The aim of this study was to investigate RET/RAS-negative MTC fo...

关键词： medullary thyroid carcinoma | NF1 | NGS | oncosuppressor | C-CELL HYPERPLASIA | NEUROFIBROMATOSIS TYPE-1 | RET | MUTATION | CANCER | CABOZANTINIB

4. Clinical Evolution of Sporadic Medullary Thyroid Carcinoma With Biochemical Incomplete Response After Initial Treatment NSTL国家科技图书文献中心

Prete, Alessandro | Gambale, Carla ... - 《The Journal of Clinical Endocrinology and Metabolism》 - 2023,108(8) - e613～e622 - 共10页

摘要：Context The clinical response after surgery is a determinant in the management of patients with medullary thyroid carcinoma (MTC). In case of excellent or structural incomplete response, the follow-up...

关键词： medullary thyroid carcinoma | biochemical incomplete response | recurrence rate | calcitonin | RET | DYNAMIC RISK STRATIFICATION | SERUM CALCITONIN | FOLLOW-UP | CARCINOEMBRYONIC ANTIGEN | CANCER INCIDENCE...

5. Pre- and Post-operative Circulating Tumoral DNA in Patients With Medullary Thyroid Carcinoma SCIE Web of Science核心 NSTL国家科技图书文献中心

Ciampi, Raffaele | Romei, Cristina ... - 《The Journal of Clinical Endocrinology and Metabolism》 - 2022,107(8) - E3420～E3427 - 共8页

摘要：Context Measurement of driver mutations in circulating tumoral DNA (ctDNA) obtained by liquid biopsy has been shown to be a sensitive biomarker in several human tumors. Objective The aim of this study...

关键词： medullary thyroid carcinoma | ctDNA | NGS | calcitonin | carcino-embryonic antigen | liquid biopsy | PROGNOSTIC-SIGNIFICANCE | NUCLEIC-ACIDS | RET | CALCITONIN...

6. Somatic RET Indels in Sporadic Medullary Thyroid Cancer: Prevalence and Response to Selpercatinib SCIE Web of Science核心 NSTL国家科技图书文献中心

Elisei, Rossella | Ciampi, Raffaele ... - 《The Journal of Clinical Endocrinology and Metabolism》 - 2022,107(8) - 2195～2202 - 共8页

摘要：Context Although the majority of RET alterations are single nucleotide variants (SNV), small deletions and/or insertions have been reported at variable prevalence. No information about the efficacy of...

关键词： medullary thyroid carcinoma | RET indels | NGS | next-generation sequencing | selpercatinib | tyrosine kinase inhibitor | CYSTEINE-RICH DOMAIN | MUTATION | DELETIONS

7. Whole Tumor Capsule Is Prognostic of Very Good Outcome in the Classical Variant of Papillary Thyroid Cancer SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Giani, Carlotta | Torregrossa, Liborio ... - 《The Journal of Clinical Endocrinology and Metabolism》 - 2021,106(10) - E4072～E4083 - 共12页

摘要：Context: Tumor capsule integrity is becoming a relevant issue to predict the biological behavior of human tumors, including thyroid cancer. Objective: This work aims to verify whether a whole tumor ca...

关键词： whole tumor capsule | papillary thyroid cancer | follicular variant | classical variant | ENCAPSULATED FOLLICULAR VARIANT | NUCLEAR FEATURES | BRAF MUTATION | CARCINOMA | ASSOCIATION | NEOPLASM...

8. BRAF K601E Mutation in Oncocytic Carcinoma of the Thyroid: A Case Report and Literature Review

Matrone, Antonio | Citro, Fabrizia ... - 《journal of clinical medicine》 - 2023,12(22) - 共13页

摘要：Background: Thyroid carcinoma (TC) is the most common endocrine cancer, with papillary thyroid carcinoma (PTC) being the most common subtype. BRAF and RAS oncogene were characterized as the most frequ...

关键词： oncocytic carcinoma of the thyroid | Hurthle cell | BRAF K601E | next generation sequencing | metastatic thyroid cancer | actionable mutation | BRAF(K601E) MUTATION | CANCER | FEATURES | DRIVERS...

9. RET mutated C-cells proliferate more rapidly than non-mutated neoplastic cells

Romei, Cristina | Ramone, Teresa ... - 《endocrine connections》 - 2021,10(2) - 124～130 - 共7页

摘要：A statistically significant higher prevalence of the RET p.Met918Thr somatic mutation, identified by direct sequencing, was previously reported in MTC > 2 cm than in smaller tumors. Aim of this study ...

关键词： medullary thyroid cancer | RET | RAS | Ki67 | allelic frequency | cells' growth | MEDULLARY-THYROID CARCINOMA | COLORECTAL-CANCER | LOW-PREVALENCE | RAS MUTATIONS...

10. Higher RET Gene Expression Levels Do Not Represent anAlternative RET Activation Mechanism in Medullary Thyroid Carcinoma

Mule, Chiara | Ciampi, Raffaele ... - 《biomolecules》 - 2021,11(10) - 共8页

摘要：This study was designed to investigate whether RET (rearranged during transfection) mRNA over-expression could be considered an alternative driver event for the development of medullary thyroid carcin...

关键词： RET | RAS | medullary thyroid carcinoma | mRNA expression | 3'-SPLICING VARIANTS | TYROSINE KINASE | PROTOONCOGENE | MUTATIONS | ISOFORMS | OVEREXPRESSION...

摘要：Purpose Aims of this study were to investigate the prevalence of TP53 and TERT mutations in Medullary Thyroid carcinoma (MTC) and their role in inducing aggressiveness in positive cases. Methods We pe...

关键词： TP53 | TERT | Medullary thyroid cancer | Oncogene | Tumor suppressor gene

摘要：Context The active surveillance (AS) program for papillary thyroid carcinoma (<= 1 cm) at low risk (mPTC) showed a low percentage of progression.Objective The aim of this study was to find a molecular...

关键词： active surveillance | molecular profile | mPTC | NGS | progression

摘要：Objective About 20% of sporadic medullary thyroid carcinomas (MTC) have no RET/RAS somatic alterations or other known gene alterations. The aim of this study was to investigate RET/RAS-negative MTC fo...

关键词： medullary thyroid carcinoma | NF1 | NGS | oncosuppressor | C-CELL HYPERPLASIA | NEUROFIBROMATOSIS TYPE-1 | RET | MUTATION | CANCER | CABOZANTINIB

摘要：Context The clinical response after surgery is a determinant in the management of patients with medullary thyroid carcinoma (MTC). In case of excellent or structural incomplete response, the follow-up...

关键词： medullary thyroid carcinoma | biochemical incomplete response | recurrence rate | calcitonin | RET | DYNAMIC RISK STRATIFICATION | SERUM CALCITONIN | FOLLOW-UP | CARCINOEMBRYONIC ANTIGEN | CANCER INCIDENCE...

摘要：Context Measurement of driver mutations in circulating tumoral DNA (ctDNA) obtained by liquid biopsy has been shown to be a sensitive biomarker in several human tumors. Objective The aim of this study...

关键词： medullary thyroid carcinoma | ctDNA | NGS | calcitonin | carcino-embryonic antigen | liquid biopsy | PROGNOSTIC-SIGNIFICANCE | NUCLEIC-ACIDS | RET | CALCITONIN...

摘要：Context Although the majority of RET alterations are single nucleotide variants (SNV), small deletions and/or insertions have been reported at variable prevalence. No information about the efficacy of...

关键词： medullary thyroid carcinoma | RET indels | NGS | next-generation sequencing | selpercatinib | tyrosine kinase inhibitor | CYSTEINE-RICH DOMAIN | MUTATION | DELETIONS

摘要：Context: Tumor capsule integrity is becoming a relevant issue to predict the biological behavior of human tumors, including thyroid cancer. Objective: This work aims to verify whether a whole tumor ca...

关键词： whole tumor capsule | papillary thyroid cancer | follicular variant | classical variant | ENCAPSULATED FOLLICULAR VARIANT | NUCLEAR FEATURES | BRAF MUTATION | CARCINOMA | ASSOCIATION | NEOPLASM...

摘要：Background: Thyroid carcinoma (TC) is the most common endocrine cancer, with papillary thyroid carcinoma (PTC) being the most common subtype. BRAF and RAS oncogene were characterized as the most frequ...

关键词： oncocytic carcinoma of the thyroid | Hurthle cell | BRAF K601E | next generation sequencing | metastatic thyroid cancer | actionable mutation | BRAF(K601E) MUTATION | CANCER | FEATURES | DRIVERS...

摘要：A statistically significant higher prevalence of the RET p.Met918Thr somatic mutation, identified by direct sequencing, was previously reported in MTC > 2 cm than in smaller tumors. Aim of this study ...

关键词： medullary thyroid cancer | RET | RAS | Ki67 | allelic frequency | cells' growth | MEDULLARY-THYROID CARCINOMA | COLORECTAL-CANCER | LOW-PREVALENCE | RAS MUTATIONS...

摘要：This study was designed to investigate whether RET (rearranged during transfection) mRNA over-expression could be considered an alternative driver event for the development of medullary thyroid carcin...

关键词： RET | RAS | medullary thyroid carcinoma | mRNA expression | 3'-SPLICING VARIANTS | TYROSINE KINASE | PROTOONCOGENE | MUTATIONS | ISOFORMS | OVEREXPRESSION...

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