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1. Safety, pharmacokinetics, and biological activity of CD4-mimetic BNM-III-170 in SHIV-infected rhesus macaques NSTL国家科技图书文献中心

Viox, Elise G. | Richard, Jonathan ... - 《Journal of Virology》 - 2025,99(5) - e0006225～e0006225 - 共25页

摘要：Anti-HIV-1 antibodies capable of mediating ADCC are elicited by the majority of people with HIV-1 and preferentially target the "open," CD4-bound conformation of HIV-1 envelope glycoproteins (Env). Ho...

关键词： human immunodeficiency virus | nonhuman primate | ADCC | CD4 mimetic | in vivo therapeutic strategies

2. DAA-mediated HCV cure reduces HIV DNA levels in HCV/HIV coinfected people NSTL国家科技图书文献中心

Gobran, Samaa T. | Pagliuzza, Amelie ... - 《Journal of Virology》 - 2023,97(12) - 共15页 - 被引量：2

摘要：The human immunodeficiency virus (HIV) persists in HIV viral reservoirs despite antiretroviral therapy (ART). Hepatitis C virus (HCV) coinfection is associated with increased HIV reservoir size and re...

关键词： direct acting antivirals | HIV viral reservoir | CD4+T-cells | hepatitis C virus | HEPATITIS-C | RESERVOIR | REPLICATION | CYTOKINE | SIZE

3. Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV CD4 + and CD8 + T cells NSTL国家科技图书文献中心

Dube, Mathieu | Tastet, Olivier ... - 《Cell Host & Microbe》 - 2023,31(9) - 1507～+ - 共22页 - 被引量：15

摘要：Spontaneous transcription and translation of HIV can persist during suppressive antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this spontaneously "active"reservoir ...

关键词： PROVIRUSES PRODUCE | REPLICATION | RESERVOIR | RNA | PERSISTENCE | VIREMIA | BLOOD | LYMPHOCYTES | INFECTION | RESPONSES

4. HIV-1 DNA and Immune Activation Levels Differ for Long-Lived T-Cells in Lymph Nodes, Compared with Peripheral Blood, during Antiretroviral Therapy NSTL国家科技图书文献中心

Mallarino-Haeger, Ch... | Pino, Maria ... - 《Journal of Virology》 - 2023,97(4) - 共11页 - 被引量：4

摘要：Elucidating the mechanisms underlying the persistence and location of the HIV reservoir is critical for developing cure interventions. While it has been shown that levels of T-cell activation and the ...

关键词： central memory CD4(+) T-cells | HIV immunology | HIV reservoir | HIV-1 infection | T-lymphocyte subsets | PERSISTENCE | TISSUE | MEMORY

5. An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+T cell magnitude and short-lived differentiation status NSTL国家科技图书文献中心

Takata, Hiroshi | Mitchell, Julie L.... - 《Cell Host & Microbe》 - 2023,31(9) - 1494～+ - 共18页 - 被引量：6

摘要：Before initiation of antiretroviral therapy (ART), HIV-specific CD8+T cells are dysfunctional and short lived. To better understand the relationship between the HIV reservoir in CD4+ T cells and the m...

关键词： CD8(+) T-CELLS | INFECTED INDIVIDUALS | PD-1 EXPRESSION | TYPE-1 RNA | DNA | PROVIRUSES | DYNAMICS | DISEASE | VIREMIA | REPLICATION

6. Detecting Sources of Immune Activation and Viral Rebound in HIV Infection SCIE Web of Science核心 NSTL国家科技图书文献中心

Wietgrefe, Stephen W... | Duan, Lijie ... - 《Journal of Virology》 - 2022,96(15) - 共10页 - 被引量：6

摘要：Anti-retroviral therapy (ART) has greatly improved the quality and length of life for people living with HIV, but immune activation does not normalize during ART, and persistent immune activation has ...

关键词： HIV | immune activation | viral rebound | HUMAN-IMMUNODEFICIENCY-VIRUS | AUTOMATED DIGITAL IMMUNOASSAY | T-CELLS | INFLAMMATION | SENSITIVITY | PROVIRUSES | EXPRESSION...

7. Safety, Immune, and Antiviral Effects of Pegylated Interferon Alpha 2b Administration in Antiretroviral Therapy-Suppressed Individuals: Results of Pilot Clinical Trial SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Papasavvas, Emmanoui... | Azzoni, Livio ... - 《AIDS Research and Human Retroviruses》 - 2021,37(6) - 433～443 - 共11页 - 被引量：6

摘要：In the pilot NCT01935089 trial, we tested whether pegylated interferon alpha2b (Peg-IFN-alpha 2b) with antiretroviral therapy (ART) was safe and could impact HIV and immune measures in blood and in gu...

关键词： pegylated IFN-alpha 2b | antiretroviral therapy | HIV RNA | HIV DNA | GALT | activation

8. Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Papasavvas, Emmanoui... | Azzoni, Livio ... - 《Clinical infectious diseases》 - 2021,72(3) - 495～498 - 共4页 - 被引量：17

摘要：Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the in...

关键词： HIV latency | IPDA | TILDA | p24 | integrated HIV | REPLICATION

9. Preferential Infection of alpha 4 beta 7(+) Memory CD4(+) T Cells During Early Acute Human Immunodeficiency Virus Type 1 Infection SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Tokarev, Andrey | McKinnon, Lyle R.... - 《Clinical infectious diseases》 - 2020,71(11) - E735～E743 - 共9页 - 被引量：10

摘要：Background. Establishment of persistent human immunodeficiency virus type 1 (HIV-1) reservoirs occurs early in infection, and biomarkers of infected CD4(+) T cells during acute infection are poorly de...

关键词： HIV-1 | acute infection | integrin beta 7 | activation

10. Potential for Virus Endogenization in Humans through Testicular Germ Cell Infection: the Case of HIV SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Mahe, Dominique | Matusali, Giulia ... - 《Journal of Virology》 - 2020,94(24) - 共19页 - 被引量：9

摘要：Viruses have colonized the germ line of our ancestors on several occasions during evolution, leading to the integration in the human genome of viral sequences from over 30 retroviral groups and a few ...