NSTL国家科技图书文献中心

1. Reducing Stress PERKs up Anti-tumor Immunity SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Charbonneau, Marie-E... | O'Riordan, Mary X. D... - 《Immunity》 - 2020,52(4) - 575～577 - 共4页

摘要：Myeloid-derived suppressor cells (MDSCs) can promote tumor progression. In this issue of Immunity, Mohamed et al. show that the unfolded protein response sensor, PERK, enhances MDSC-mediated immunosup...

2. Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Passalacqua, Karla D... | Charbonneau, Marie-E...... - 《Antimicrobial agents and chemotherapy.》 - 2016,60(7) - 4183～4196 - 共14页

摘要：Due to the rise of antibiotic resistance and the small number of effective antiviral drugs, new approaches for treating infectious diseases are urgently needed. Identifying targets for host-based ther...

3. Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3-and Caspase-2-Driven Mitochondrial Damage SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Bronner, Denise N. | Abuaita, Basel H.... - 《Immunity》 - 2015,43(3) - 451～462 - 共123页

摘要：Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated with inflammation. ER stress can trigger inflammation through nucleotide-binding domain and leucine-rich repeat c...

4. STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis

Uddin, Jazib | Sharma, Ankit ... - 《jci insight》 - 2024,9(22) - 共19页

摘要：Susceptibility to inflammatory bowel diseases (IBDs), Crohn's disease (CD), and ulcerative colitis (UC) is linked with loss of intestinal epithelial barrier integrity and mitochondria dysfunction. Ste...

关键词： ACTIVATED PROTEIN-KINASE | ULCERATIVE-COLITIS | COLON-CANCER | PHOSPHATIDYLCHOLINE | DYSFUNCTION | EXPRESSION | REGULATOR | TRANSPORT | FISSION | COMPLEX

5. The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α

Gao, Fushan | Reynolds, Mack B.... - 《frontiers in cellular and infection microbiology》 - 2021,10 - 共14页

摘要：The mitochondrial network plays a critical role in the regulation of innate immune signaling and subsequent production of proinflammatory cytokines such as IFN-beta and IL-1 beta. Dynamin-related prot...

关键词： mitochondria | inflammation | macrophage | cellular stress | cytokine | DYNAMIN-RELATED PROTEIN-1 | NECROSIS-FACTOR-ALPHA | NLRP3 INFLAMMASOME | OXIDATIVE STRESS | CYCLOSPORINE-A...

6. Perturbation of ubiquitin homeostasis promotes macrophage oxidative defenses

Charbonneau, Marie-E... | Passalacqua, Karla D...... - 《scientific reports》 - 2019,9 - 共14页

摘要：The innate immune system senses microbial ligands through pattern recognition and triggers downstream signaling cascades to promote inflammation and immune defense mechanisms. Emerging evidence sugges...

关键词： DEUBIQUITINATING ENZYME | PROTEIN HOMEOSTASIS | EMERGING FUNCTIONS | MECHANISMS | PROTEASOME | DEGRADATION | INHIBITION | DISEASE | ROLES | HOST

7. Glycolysis Is an Intrinsic Factor for Optimal Replication of a Norovirus

Passalacqua, Karla D... | Lu, Jia ... - 《mbio》 - 2019,10(2) - 共18页

摘要：The metabolic pathways of central carbon metabolism, glycolysis and oxidative phosphorylation (OXPHOS), are important host factors that determine the outcome of viral infections and can be manipulated...

关键词： calicivirus | carbon metabolism | glycolysis | noroviruses | oxidative phosphorylation | pentose phosphate pathway | ACTIVATED PROTEIN-KINASE | BLOOD GROUP ANTIGENS | MURINE NOROVIRUS | CELLULAR-METABOLISM...

8. Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape

Kolawole, Abimbola O... | Mirabelli, Carmen ... - 《plos pathogens》 - 2019,15(10) - 共30页

摘要：Human astroviruses (HAstV) are understudied positive-strand RNA viruses that cause gastroenteritis mostly in children and the elderly. Three clades of astroviruses, classic, MLB-type and VA-type have ...

关键词： STEM-CELLS | EXPRESSION | INHIBITION | INFECTION | 2'-C-METHYLCYTIDINE | INDUCTION | EXPANSION | NOROVIRUS | DIARRHEA | MARKER

9. Invasion of the Brain by Listeria monocytogenes Is Mediated by InlF and Host Cell Vimentin

Ghosh, Pallab | Halvorsen, Elizabeth...... - 《mbio》 - 2018,9(1) - 共11页

摘要：
Listeria monocytogenes is a facultative intracellular bacterial pathogen that is frequently associated with food-borne infection. Of particular concern is the ability of ...

关键词： InlF | Listeria monocytogenes | adhesion | brain | invasion | meningitis | vimentin | MICROVASCULAR ENDOTHELIAL-CELLS | ACUTE BACTERIAL-MENINGITIS | MICE LACKING VIMENTIN...

10. Small Molecule Deubiquitinase Inhibitors Promote Macrophage Anti-Infective Capacity

Charbonneau, Marie-E... | Gonzalez-Hernandez, ...... - 《plos one》 - 2014,9(8) - 共11页

摘要：
The global spread of anti-microbial resistance requires urgent attention, and diverse alternative strategies have been suggested to address this public health concern. Ho...

关键词： INFECTIOUS-DISEASES SOCIETY | NORWALK VIRUS-RNA | LISTERIA-MONOCYTOGENES | UBIQUITIN SYSTEM | UNITED-STATES | ENZYMES | CELLS | REPLICATION | NOROVIRUSES | PROTEASOME

摘要：Myeloid-derived suppressor cells (MDSCs) can promote tumor progression. In this issue of Immunity, Mohamed et al. show that the unfolded protein response sensor, PERK, enhances MDSC-mediated immunosup...

摘要：Due to the rise of antibiotic resistance and the small number of effective antiviral drugs, new approaches for treating infectious diseases are urgently needed. Identifying targets for host-based ther...

摘要：Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated with inflammation. ER stress can trigger inflammation through nucleotide-binding domain and leucine-rich repeat c...

摘要：Susceptibility to inflammatory bowel diseases (IBDs), Crohn's disease (CD), and ulcerative colitis (UC) is linked with loss of intestinal epithelial barrier integrity and mitochondria dysfunction. Ste...

关键词： ACTIVATED PROTEIN-KINASE | ULCERATIVE-COLITIS | COLON-CANCER | PHOSPHATIDYLCHOLINE | DYSFUNCTION | EXPRESSION | REGULATOR | TRANSPORT | FISSION | COMPLEX

摘要：The mitochondrial network plays a critical role in the regulation of innate immune signaling and subsequent production of proinflammatory cytokines such as IFN-beta and IL-1 beta. Dynamin-related prot...

关键词： mitochondria | inflammation | macrophage | cellular stress | cytokine | DYNAMIN-RELATED PROTEIN-1 | NECROSIS-FACTOR-ALPHA | NLRP3 INFLAMMASOME | OXIDATIVE STRESS | CYCLOSPORINE-A...

摘要：The innate immune system senses microbial ligands through pattern recognition and triggers downstream signaling cascades to promote inflammation and immune defense mechanisms. Emerging evidence sugges...

关键词： DEUBIQUITINATING ENZYME | PROTEIN HOMEOSTASIS | EMERGING FUNCTIONS | MECHANISMS | PROTEASOME | DEGRADATION | INHIBITION | DISEASE | ROLES | HOST

摘要：The metabolic pathways of central carbon metabolism, glycolysis and oxidative phosphorylation (OXPHOS), are important host factors that determine the outcome of viral infections and can be manipulated...

关键词： calicivirus | carbon metabolism | glycolysis | noroviruses | oxidative phosphorylation | pentose phosphate pathway | ACTIVATED PROTEIN-KINASE | BLOOD GROUP ANTIGENS | MURINE NOROVIRUS | CELLULAR-METABOLISM...

摘要：Human astroviruses (HAstV) are understudied positive-strand RNA viruses that cause gastroenteritis mostly in children and the elderly. Three clades of astroviruses, classic, MLB-type and VA-type have ...

关键词： STEM-CELLS | EXPRESSION | INHIBITION | INFECTION | 2'-C-METHYLCYTIDINE | INDUCTION | EXPANSION | NOROVIRUS | DIARRHEA | MARKER

摘要：Listeria monocytogenes is a facultative intracellular bacterial pathogen that is frequently associated with food-borne infection. Of particular concern is the ability of ...

关键词： InlF | Listeria monocytogenes | adhesion | brain | invasion | meningitis | vimentin | MICROVASCULAR ENDOTHELIAL-CELLS | ACUTE BACTERIAL-MENINGITIS | MICE LACKING VIMENTIN...

摘要：The global spread of anti-microbial resistance requires urgent attention, and diverse alternative strategies have been suggested to address this public health concern. Ho...

关键词： INFECTIOUS-DISEASES SOCIETY | NORWALK VIRUS-RNA | LISTERIA-MONOCYTOGENES | UBIQUITIN SYSTEM | UNITED-STATES | ENZYMES | CELLS | REPLICATION | NOROVIRUSES | PROTEASOME

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国家科技图书文献中心

摘要：
Listeria monocytogenes is a facultative intracellular bacterial pathogen that is frequently associated with food-borne infection. Of particular concern is the ability of ...

摘要：
The global spread of anti-microbial resistance requires urgent attention, and diverse alternative strategies have been suggested to address this public health concern. Ho...