NSTL国家科技图书文献中心

1. Characterization of NK-lysin A, a potent antimicrobial peptide from the zebrafish Danio rerio NSTL国家科技图书文献中心

Ortjohann, Marius | Leippe, Matthias - 《Developmental and Comparative Immunology》 - 2025,162 - 共10页

摘要：Antimicrobial peptides (AMPs) are important players of the innate immune system with a major role in the defense against invading pathogens. AMPs belonging to the family of saposin-like proteins (SAPL...

关键词： NK-Lysin | Antimicrobial peptide | Zebrafish | SAPLIP | Antibacterial | Innate immune system

2. Molecular characterization of two newly recognized lysozymes of the protist Dictyostelium discoideum NSTL国家科技图书文献中心

Ortjohann, Marius | Leippe, Matthias - 《Developmental and Comparative Immunology》 - 2025,164 - 共11页

摘要：The model organism Dictyostelium discoideum functions as a social amoeba that can aggregate, eventually forming a fruiting body composed of a fixed number of cells. This behavior requires a soluble co...

关键词： Antimicrobial protein | Counting factor | GH25 lysozymes | Neighboring group catalytic mechanism | pH dependency

3. Digital Microfluidics Supported Microproteomics for Quantitative Proteome Analysis of Single Caenorhabditis elegans Nematodes SCIE Web of Science核心 NSTL国家科技图书文献中心

Steinbach, Max K. | Leipert, Jan ... - 《Journal of proteome research》 - 2022,21(8) - 1986～1996 - 共11页 - 被引量：12

摘要：ABSTRACT: Miniaturization of sample preparation, including omissible manual sample handling steps, is key for reproducible nanoproteomics, as material is often restricted to only hundreds of cells or ...

关键词： digital micro fl uidics | Caenorhabditis elegans | PALMS | label-free quanti fi cation | low-input proteomics | microproteomics | nanoproteomics | COMPUTATIONAL PLATFORM | PLURONIC ADDITIVES | SAMPLE PREPARATION...

4. Designed Trp-Cage Proteins with Antimicrobial Activity and Enhanced Stability EI 工程索引 SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Preusske, Nils | Lipfert, Matthias ... - 《Biochemistry》 - 2021,60(42) - 3187～3199 - 共13页

摘要：alpha-Helical antimicrobial peptides (alpha AMPs) are among the potential candidates for new anti-infectives to tackle the global crisis in antibiotic resistance, but they suffer from low bioavailabil...

关键词： HUMAN CATHELICIDIN LL-37 | HIGH-AFFINITY LIGANDS | CHEMICAL-SHIFT INDEX | SECONDARY STRUCTURE | ESCHERICHIA-COLI | PEPTIDE LL-37 | ALPHA-HELIX | AMINO-ACIDS | DEGRADATION | EXENDIN-4

5. Alkaline guts contribute to immunity during exposure to acidified seawater in the sea urchin larva SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Stumpp, Meike | Petersen, Inga ... - 《The Journal of Experimental Biology》 - 2020,223(9) - 共9页 - 被引量：5

摘要：Larval stages of members of the Abulacraria superphylum including echinoderms and hemichordates have highly alkaline midguts. To date, the reason for the evolution of such extreme pH conditions in the...

关键词： Vibrio diazotrophicus | Ocean acidification | Bacterial infection | Na+/H+-exchange | Ion selective micro-electrodes

6. Granulysin species segregate to different lysosome-related effector vesicles (LREV) and get mobilized by either classical or non-classical degranulation SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Lettau, Marcus | Dietz, Michelle ... - 《Molecular Immunology》 - 2019,107 - 44～53 - 共10页 - 被引量：8

摘要：Granulysin (GNLY) is a cationic antimicrobial, proinflammatory, and cytotoxic effector protein primarily expressed in human cytotoxic T and NK cells. Its two variants, the 15 kDa precursor and the mat...

关键词： Granulysin | Fas ligand (CD178) | CD107a | Secretory lysosomes | Cytotoxic granules | Lysosome-related effector vesicles | T cells | NK cells

7. Miniaturized dispersive liquid-liquid microextraction and MALDI MS using ionic liquid matrices for the detection of bacterial communication molecules and virulence factors NSTL国家科技图书文献中心

Leipert, Jan | Bobis, Ingrid ... - 《Analytical and bioanalytical chemistry》 - 2018,410(19) - 4737～4748 - 共12页 - 被引量：8

摘要：The identification and quantification of molecules involved in bacterial communication are major prerequisites for the understanding of interspecies interactions at the molecular level. We developed a...

关键词： Biofilm | Cystic fibrosis | Pseudomonas aeruginosa | Pyocyanin | Quorum sensing | Resistance

8. Identification and Quantification of N-Acyl Homoserine Lactones Involved in Bacterial Communication by Small-Scale Synthesis of Internal Standards and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Leipert, Jan | Treitz, Christian ... - 《Journal of the American Society for Mass Spectrometry》 - 2017,28(12) - 2538～2547 - 共10页 - 被引量：10

摘要：N-acyl homoserine lactones (AHL) are small signal molecules involved in the quorum sensing of many gram-negative bacteria, and play an important role in biofilm formation and pathogenesis. Present ana...

关键词： Ionic liquid matrices | Quantification | Low molecular weight | Quorum sensing | Quantitative MALDI | Internal standard | Isotope labeling

9. Quantitative proteome analysis of Caenorhabditis elegans upon exposure to nematicidal Bacillus thuringiensis NSTL国家科技图书文献中心

Treitz, Christian | Cassidy, Liam ... - 《Journal of proteomics》 - 2015,113 - 337～350 - 共14页 - 被引量：33

摘要：Caenorhabditis elegans can be infected by a plethora of pathogens, most of them are also pathogenic for humans. Consequently, the nematode has emerged as a powerful surrogate host to model microbial h...

关键词： Innate immune system | iTRAQ | High pH reversed-phase chromatography | Mass spectrometry | Model organism | Proteomics

10. Overlapping and unique signatures in the proteomic and transcriptomic responses of the nematode Caenorhabditis elegans toward pathogenic Bacillus thuringiensis NSTL国家科技图书文献中心

Yang, Wentao | Dierking, Katja ... - 《Developmental and Comparative Immunology: Ontogeny, Phylogeny, Aging: The Official Journal of the International Society of Developmental and Comparative Immunology》 - 2015,51(1) - 1～9 - 共9页 - 被引量：23

摘要：Pathogen infection can activate multiple signaling cascades that ultimately alter the abundance of molecules in cells. This change can be measured both at the transcript and protein level. Studies ana...