NSTL国家科技图书文献中心

1. Population pharmacokinetics of sivelestat in Chinese patients with severe pneumonia NSTL国家科技图书文献中心

Zhang, Xiaolin | Hu, Huiliang ... - 《Fundamental & clinical pharmacology.》 - 2025,39(2) - e70001～e70001 - 共10页

摘要：Background: Sivelestat sodium, an inhibitor of neutrophil elastase, was broadly used in the treatment of severe pneumonia. However, the pharmacokinetic (PK) characteristics of sivelestat in patients w...

关键词： model-informed precision dosing | population pharmacokinetics | severe pneumonia | sivelestat | model‐informed precision dosing | monolix2024R1

2. Pathologically complete remission to combination of invariant NK T cells and anti-CD20 antibody in a refractory HIV plus diffuse large B-cell lymphoma patient SCIE Web of Science核心 NSTL国家科技图书文献中心

Wang, Jing | Zhang, Renfang ... - 《Immunotherapy》 - 2022,14(8) - 599～607 - 共9页

摘要：Although there is a high curability rate with rituximab chemotherapy, approximately 40% of patients with diffuse large B-cell lymphoma (DLBCL) develop disease relapse or primary-refractory lymphoma. T...

关键词： anti-CD20 antibody | chemo-immunotherapy | DLBCL | HIV plus | iNKT | pathologically complete regression | relapsed | refractory | rituximab | THERAPY...

3. Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Li, Ang | Ling, Yun ... - 《The Journal of Infectious Diseases》 - 2021,223(4) - 568～580 - 共13页 - 被引量：9

摘要：Background. The immune protective mechanisms during severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection remain to be deciphered for the development of an effective intervention approa...

关键词： IL-37 | SARS-CoV-2 | COVID-19 | inflammation | clinical outcomes

4. The Upregulation of LAG-3 on T Cells Defines a Subpopulation with Functional Exhaustion and Correlates with Disease Progression in HIV-Infected Subjects SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Tian, Xiaoling | Zhang, Anli ... - 《The Journal of Immunology: Official Journal of the American Association of Immunologists》 - 2015,194(8) - 3873～3882 - 共10页 - 被引量：71

摘要：T cells develop functional defects during HIV-1 infection, partially due to the upregulation of inhibitory receptors such as programmed death-1 (PD-1) and CTLA-4. However, the role of lymphocyte activ...

5. Frequency Shift of a Crystal Quartz Resonator in Thickness-Shear Modes Induced by an Array of Hemispherical Material Units SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Hu, Yuantai | Hu, Huiliang ... - 《IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control》 - 2013,60(8) - 1777～1782 - 共6页 - 被引量：7

摘要：A two-dimensional model was established to study the dynamic characteristics of a quartz crystal resonator with the upper surface covered by an array of hemispherical material units. A frequency-depen...

6. Hyper-methylation and DNMT3A mediated LTC4S downregulation promoted lung adenocarcinoma tumorigenesis via mTORC1 signaling pathway

Ren, Yang | Zhang, Peng ... - 《Heliyon》 - 2024,10(13) - 共13页

摘要：Background: Lung adenocarcinoma is a malignancy characterized by high mortality rates and unfavorable prognosis. However, the role of Leukotriene C4 Synthase (LTC4S) in lung cancer remains uninvestiga...

关键词： Lung adenocarcinoma (LUAD) | Leukotriene C4 Synthase (LTC4S) | Prognosis | mTORC1 signaling pathway | DNA methylation | CANCER

7. Safety and Clinical Response to Combined Immunotherapy with Autologous iNKT Cells and PD-1+CD8+ T Cells in Patients Failing First-line Chemotherapy in Stage IV Pancreatic Cancer

Wang, Jing | Cheng, Xiaobo ... - 《cancer research communications》 - 2023,3(6) - 991～1003 - 共13页

摘要：Purpose: A phase I clinical trial was conducted to assess the safety and feasibility of invariant natural killer T (iNKT) cells combined with PD-1+CD8+ T cells in patients with advanced pancreatic can...

关键词： PERIPHERAL-BLOOD | ADOPTIVE TRANSFER | NKT CELLS | MELANOMA | LYMPHOCYTES | EFFICACY | THERAPY | MICROENVIRONMENT | IDENTIFICATION | INFILTRATION

8. Risk Factors and Mental Health Status in Patients With Non-Tuberculous Mycobacterial Lung Disease: A Single Center Retrospective Study

Zhao, Zhangyan | Hu, Huiliang ... - 《frontiers in public health》 - 2022,10 - 共8页

摘要：According to the existing data, the incidence and prevalence of non-tuberculous mycobacteria (NTM) are increasing worldwide. The risk factors and mental health status of patients with NTM lung disease...

关键词： NTM | NTM lung disease | mental health | influencing factors | anxiety | CLINICAL-FEATURES | PULMONARY-DISEASE | EPIDEMIOLOGY | INFECTION | WOMEN

9. Improving the ex vivo expansion of human tumor-reactive CD8+T cells by targeting toll-like receptors

Qiu, Chenli | Wang, Jing ... - 《frontiers in bioengineering and biotechnology》 - 2022,10 - 共12页 - 被引量：2

摘要：Toll-like receptors (TLRs) are important pattern recognition receptor(s) known to mediate the sensing of invading pathogens and subsequent immune responses. In this study, we investigate whether TLRs ...

关键词： toll-like receptors | agonists | adoptive cell therapy | human PD1+CD8(+) T cells | cell proliferation | tumor cell killing | CD8(+) T-CELLS | TLR2 ENGAGEMENT | PERIPHERAL-BLOOD | PROLIFERATION...

10. An open, prospective cohort study of VV116 in Chinese participants infected with SARS-CoV-2 omicron variants

Shen, Yinzhong | Ai, Jingwen ... - 《emerging microbes & infections》 - 2022,11(1) - 1518～1523 - 共6页

摘要：Omicron variant of SARS-CoV-2 has become the predominant variant worldwide. VV116 is an oral drug with robust anti-SARS-CoV-2 efficacy in preclinical studies. We conducted an open, prospective cohort ...