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1. MxA suppresses TAK1-IKK alpha/beta-NF-kappa B mediated inflammatory cytokine production to facilitate Mycobacterium tuberculosis infection SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Zhou, Xinying | Zhang, Lijie ... - 《Journal of Infection》 - 2020,81(2) - 231～241 - 共11页 - 被引量：11

摘要：Objectives: Interferons (IFNs) play multifunctional roles in host defense against infectious diseases by inducing IFN-stimulated genes (ISGs). However, little is known about how ISGs regulate host imm...

关键词： Mycobacterium tuberculosis (Mtb) | Myxovirus resistance protein 1 (MxA) | Macrophages (M phi s) | TGF-beta-activating kinase 1 (TAK1) | I kappa B kinase alpha/beta (IKK alpha/beta) | Nuclear factor-kappa B (NF-kappa B)

2. Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Zhou, Xinying | Yang, Jiahui ... - 《Journal of Infection》 - 2019,79(3) - 262～276 - 共15页 - 被引量：8

摘要：Objectives: Although it has been reported that Interferon regulatory factor 1 (IRF1) inhibits Mycobacterium tuberculosis (Mtb) infection via inducible nitric oxide synthase (iNOS) in mice, how it coun...

关键词： Mycobacterium tuberculosis (Mtb) | Interferon regulatory factor 1 (IRF1) | Macrophages (M phi s) | Mechanistic target of rapamycin signaling (mTOR) | p70 S6 kinase (p70 S6K)

3. USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10 SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Fu, Yuling | Wang, Peng ... - 《Cell death and differentiation》 - 2021,28(10) - 2857～2870 - 共14页 - 被引量：8

摘要：Deubiquitinases (DUBs) regulate diverse biological processes and represent a novel class of drug targets. However, the biological function of only a small fraction of DUBs, especially in adaptive immu...

4. beta-Arrestin 2 Regulates Inflammatory Responses against Mycobacterium tuberculosis Infection through ERK1/2 Signaling SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Wen, Qian | Li, Yanfen ... - 《The Journal of Immunology: Official Journal of the American Association of Immunologists》 - 2021,206(11) - 2623～2637 - 共15页 - 被引量：1

摘要：Mycobacterium tuberculosis, the pathogen that causes tuberculosis, exhibits complex host-pathogen interactions. Pattern recognition receptors and their downstream signaling pathways play crucial roles...

5. MiR-381-3p Regulates the Antigen-Presenting Capability of Dendritic Cells and Represses Antituberculosis Cellular Immune Responses by Targeting CD1c SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Wen, Qian | Zhou, Chaoying ... - 《The Journal of Immunology: Official Journal of the American Association of Immunologists》 - 2016,197(2) - 580～589 - 共10页 - 被引量：15

摘要：Tuberculosis is still the widest spread infectious disease in the world, and more in-depth studies are needed on the interaction between the pathogen and the host. Due to the highest lipid components ...

6. UCHL1 Promoted Polarization of M1 Macrophages by Regulating the PI3K/AKT Signaling Pathway

Huang, Yulan | He, Shitong ... - 《journal of inflammation research》 - 2022,15 - 735～746 - 共12页

摘要：Background: As deubiquitinases (DUBs), ubiquitin C-terminal hydrolase (UCH)-L1 has been shown to play a crucial role in regulating diverse biological processes. However, its function in macrophage pol...

关键词： UCHL1 | macrophages | AKT | p110 alpha | autophagy | UCH-L1 | CANCER | UBIQUITINATION | ACTIVATION | SYSTEM...

7. Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine-1-phosphate in a sphingosine-1-phosphate lyase-dependent manner

Du, Xialin | Yang, Yalong ... - 《journal of cellular and molecular medicine》 - 2020,24(22) - 13129～13138 - 共10页 - 被引量：12

摘要：Vitamin B6 is necessary to maintain normal metabolism and immune response, especially the anti-inflammatory immune response. However, the exact mechanism by which vitamin B6 plays the anti-inflammator...

关键词： anti-inflammatory | inflammatory disease | sphingosine-1-phosphate | sphingosine-1-phosphate lyase | Vitamin B6 | METABOLISM | MACROPHAGES | ACTIVATION | DISEASE | MICE

8. The Multiplicity of Infection-Dependent Effects of Recombinant Adenovirus Carrying HGF Gene on the Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells

Wen, Qian | Zhang, Shimeng ... - 《international journal of molecular sciences》 - 2018,19(3) - 共12页

摘要：Absence of effective therapeutic methods for avascular necrosis of femoral head (ANFH) is still perplexing the world's medical community. Bone marrow mesenchymal stem cells (BMSCs) adoptive cell thera...

关键词： avascular necrosis of femoral head | human bone marrow mesenchymal stem cell | hepatocyte growth factor | adenovirus | signaling pathway | proliferation | osteogenesis | GROWTH-FACTOR | IN-VITRO | RECEPTOR

9. Vitamin B5 Reduces Bacterial Growth via Regulating Innate Immunity and Adaptive Immunity in Mice Infected with Mycobacterium tuberculosis

He, Wenting | Hu, Shengfeng ... - 《frontiers in immunology》 - 2018,9 - 共8页 - 被引量：33

摘要：
The mechanisms by which vitamins regulate immunity and their effect as an adjuvant treatment for tuberculosis have gradually become very important research topics. Studie...

关键词： tuberculosis | vitamin B5 | pro-inflammation | antibacteria | macrophages | immune cells | T-CELLS | MALNUTRITION | POLARIZATION | EXPRESSION

10. Vitamin B1 Helps to Limit Mycobacterium tuberculosis Growth via Regulating Innate Immunity in a Peroxisome Proliferator-Activated Receptor-gamma-Dependent Manner

Hu, Shengfeng | He, Wenting ... - 《frontiers in immunology》 - 2018,9 - 共9页 - 被引量：12

摘要：
It is known that vitamin B1 (VB1) has a protective effect against oxidative retinal damage induced by anti-tuberculosis drugs. However, it remains unclear whether VB1 reg...

关键词： Mycobacterium tuberculosis | vitamin B1 | macrophages | peroxisome proliferator | activated receptor-gamma | adjuvant | PPAR-GAMMA | THIAMINE PYROPHOSPHATE | NUCLEAR RECEPTORS | MACROPHAGE...