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1. Neuroinflammation associated with proviral DNA persists in the brain of virally suppressed people with HIV

Byrnes, Sarah J. |  Jamal Eddine, Janna... -  《frontiers in immunology》 - 2025,16 - 共13页

摘要:Despite viral suppression with antiretroviral therapy (ART), people with HIV (PWH) continue to exhibit brain pathology, and similar to 20% of individuals develop HIV-associated neurocognitive disorder...
关键词: HIV |  brain |  neuroinflammation |  reservoirs |  microglia |  astrocytes |  NECROSIS-FACTOR-ALPHA |  IMMUNE ACTIVATION |  ANTIRETROVIRAL THERAPY |  CEREBROSPINAL-FLUID...

2. HIV transcription persists in the brain of virally suppressed people with HIV

Eddine, Janna Jamal |  Angelovich, Thomas A...... -  《plos pathogens》 - 2024,20(8) - 共16页 - 被引量:1

摘要:HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated neurocognitive disorders. Whether HIV transcription persists in the brain despite viral suppression wit...
关键词: VIRUS |  RNA |  GUT

3. Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV plus rhesus macaques

Byrnes, Sarah J. |  Busman-Sahay, Kathle...... -  《plos pathogens》 - 2023,19(3) - 共26页 - 被引量:1

摘要:HIV-associated neurocognitive disorders (HAND) affect similar to 40% of virally suppressed people with HIV (PWH), however, the precise viral dependent and independent changes to the brain are unclear....
关键词: ANTIRETROVIRAL THERAPY |  CEREBROSPINAL-FLUID |  CHRONIC HIV |  NERVOUS-SYSTEM |  T-CELLS |  NEUROCOGNITIVE IMPAIRMENT |  MONOCYTE ACTIVATION |  IMMUNODEFICIENCY |  INFLAMMATION |  INFECTION

4. Non-Human Primate Models of HIV Brain Infection and Cognitive Disorders

Byrnes, Sarah J. |  Angelovich, Thomas A...... -  《Viruses》 - 2022,14(9) - 共20页

摘要:Human Immunodeficiency virus (HIV)-associated neurocognitive disorders are a major burden for people living with HIV whose viremia is stably suppressed with antiretroviral therapy. The pathogenesis of...
关键词: non-human primates |  HIV |  SIV |  cognitive disorders |  SIMIAN IMMUNODEFICIENCY VIRUS |  CENTRAL-NERVOUS-SYSTEM |  T-CELL DEPLETION |  MAGNETIC-RESONANCE-SPECTROSCOPY |  DRIVING SIMULATOR PERFORMANCE |  CEREBROSPINAL-FLUID...
检索条件作者:Byrnes, Sarah J.
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